Neuropsychological rehabilitation for multiple sclerosis

Changes of brain resting state functional connectivity predict the persistence of cognitive rehabilitation effects in patients with multiple sclerosis

“…need to identify therapeutic interventions able to alleviate these deficits. Despite the fact that cognitive rehabilitation is widely used in clinical practice, recent Cochrane revisions stated that, at present, mainly due to methodological limitations and heterogeneity of the those studies that have been performed, there is only low level evidence for the positive effects of neuropsychological rehabilitation in MS. 14,15 In this context, despite the fact that our study is not without its limitations, including the small sample size, the lack of a computer-based sham intervention in the control group, and the absence of a group of healthy controls undergoing the same cognitive training, our findings support those of recent investigations of the medium-term efficacy of cognitive rehabilitation in RRMS patients. 7,9 To minimize a possible practice effect on longitudinal neuropsychological evaluation, we used (when available) alternative forms of the tests.…”

Processing speed and working memory training in multiple sclerosis: A double-blind randomized controlled pilot study

“…Additionally, Chiaravalloti and colleagues (2013) recently demonstrated Class I evidence of the efficacy of a program designed to improve learning with MS patients, as they found a significantly improved learning slope when compared to controls. In the most recent comprehensive review of the literature on cognitive training with MS patients, there was low-level evidence that utilizing only cognitive training with MS patients changes cognitive skills (Rosti-Otajärvi & Hämäläinen, 2014). In the review, studies utilizing cognitive training improved memory span and working memory only, which we were unable to demonstrate.…”

Neuroenhancement through cognitive training and anodal tDCS in multiple sclerosis

“…Recently, intensive cognitive rehabilitation approaches targeting attention/information processing speed, memory and executive function [2][3][4][5] have been shown to have positive effects on cognitive deficits and quality of life in patients.…”