Neuropsychological screening of a group of preterm twins: comparison with singletons

Einaudi, Marie-Ange; Busuttil, Muriel; Monnier, André; Chanus, Isabelle; Palix, C.; Gire, Catherine

doi:10.1007/s00381-007-0422-6

Cited by 13 publications

(11 citation statements)

References 21 publications

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“…In terms of cognitive performance, results are mixed. One study suggested that MC twins have higher rates of pathological nonverbal performance and learning disabilities (Einaudi et al 2008 ), whereas other studies showed no difference in mental development indexes (e.g., on the Bayley; Welch et al 1978 ; Steingass et al 2013 ). Studies examining cerebral palsy are inconsistent, with some suggesting that MC twins are at a higher risk (Burguet et al 1995 , 1999 ), but others finding no difference in prevalence of cerebral palsy in MC versus DC twins (Steingass et al 2013 ; Hack et al 2009 ), or that the association was attenuated when controlling on other perinatal factors (Livinec et al 2005 ).…”

Section: Resultsmentioning

confidence: 99%

The Prenatal Environment in Twin Studies: A Review on Chorionicity

et al. 2016

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A literature search was conducted to identify articles examining the association of chorionicity (e.g., whether twins share a single chorion and thus placenta or have separate chorions/placentas) and genetics, psychiatry/behavior, and neurological manifestations in humans twins and higher-order multiples. The main aim was to assess how frequently chorionicity has been examined in relation to heritability estimates, and to assess which phenotypes may be most sensitive to, or affected by, bias in heritability estimates because of chorionicity. Consistent with the theory that some chorionicity effects could lead to overestimation and others to underestimation of heritability, there were instances of each across the many phenotypes reviewed. However, firm conclusions should not be drawn since some of the outcomes were only examined in one or few studies and often sample sizes were small. While the evidence for bias due to chorionicity was mixed or null for many outcomes, results do, however, consistently suggest that heritability estimates are underestimated for measures of birth weight and early growth when chorionicity is not taken into account.Electronic supplementary materialThe online version of this article (doi:10.1007/s10519-016-9782-6) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

The Prenatal Environment in Twin Studies: A Review on Chorionicity

et al. 2016

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“…MC and twin birth weight discordance are the only variables associated to a higher prevalence of language delay, cognitive and attention deficit at the age of 4 years [30]. MC twins, especially if born prematurely and sIUGR, are at a higher risk not only of major neurological sequelae such as CP and neurosensory deficits, but also of minor neurodevelopmental sequelae, potentially leading to future academic and social integration difficulties.…”

Section: Neurodevelopmental Outcomesmentioning

confidence: 99%

Prematurity and twinning

Giuffrè

Piro

Corsello

2012

The Journal of Maternal-Fetal & Neonatal Medicine

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Aim of the study: Newborns from multiple pregnancies are increasing in number and demonstrate a higher perinatal morbidity and mortality compared to singletons. Prematurity is the main reason for most neonatal diseases in twins, but other variables may play a role and their prenatal evaluation may improve the overall outcome. Main findings: Prematurity is six times more frequent in twins and therefore birth weight is significantly lower compared to singletons. Thus, twins are more exposed to prematurity related diseases (respiratory, cardiovascular, infectious, etc.) and to long-term complications (especially neurological disabilities). Results: It is very difficult to estimate the increased risk of neonatal morbidity related to twinning independently to the increased risk of prematurity and therefore to interpret data on morbidity rates, in particular regarding the neurodevelopmental outcome. Conclusion: Prevention of preterm birth is a primary goal in managing multiple pregnancies, together with prophylaxis with corticosteroids in order to improve foetal lung maturity. Accurate risk assessment strategies and adequate obstetrical-neonatological management of multiple pregnancies may reduce the increasing need for neonatal intensive care and for health resources in the long-term follow-up that has been observed over the last decades.

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“…From many cohorts and case studies it appears that during early childhood, the cognitive skills of twins are influenced by GA, birth weight and the zygosity-chorionicity status of the pregnancy [39,71,72] . Towards adulthood, genetic and environmental factors become more pronounced.…”

Section: Cognitive Outcome In Multiplesmentioning

confidence: 99%

Outcomes of Multiplets

2008

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Outcomes, both short and long term, differ between singletons and multiplets. Recently, a number of large, well-designed studies have clarified these differences, particularly in light of major changes in perinatal and neonatal care that have influenced changing outcomes. Accordingly, this article will review risks for singletons, twins and higher-order multiples as whole groups and also after correction for gestational age and other potential confounding variables that differ markedly between the groups. In addition, we will focus on the effects of certain factors such as antenatal steroid therapy and gender. Finally, we will detail the specific long-term risks for multiples in terms of growth and neurodevelopmental disabilities.

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Neuropsychological screening of a group of preterm twins: comparison with singletons

Abstract: The twins' neuropsychological outcome was not more marked than that of the singletons. Birth weight discordance and chorionicity were the only predictive perinatal factors with worse outcome in the twin population.

Cited by 13 publications

References 21 publications

The Prenatal Environment in Twin Studies: A Review on Chorionicity

The Prenatal Environment in Twin Studies: A Review on Chorionicity

Prematurity and twinning

Outcomes of Multiplets

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