Neuropsychological sequelae of the treatment of children with medulloblastoma

Dennis, Maureen; Bj, Spiegler; Cr, Hetherington; Ml, Greenberg

doi:10.1007/bf00165522

Cited by 167 publications

(96 citation statements)

References 51 publications

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“…The 10-year progression-free survival was 100% and tumor relapse was observed in only one patient 10.5 years after initial diagnosis. With improved survival rates in pediatric brain tumors, awareness of significant tumor-related and/or therapy-related long-term neurological, cognitive, emotional, or behavioral complications has increased [32][33][34][35][36].…”

Section: Discussionmentioning

confidence: 99%

Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life

et al. 2008

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Objects To study the long-term outcome of surgically treated low-grade cerebellar astrocytomas in children. Materials and methods We followed 31 consecutive patients under 16 years of age who were diagnosed between 1980 and 2005 in a single institution. In 21 of 31 survivors (median follow-up time 7.9 years; range 5.6-27.4 years) who agreed to participate, tumor control, neurological and cognitive complications, and their impact on behavioral and emotional adjustment and health-related quality of life (HRQoL) were comprehensively assessed qualitatively and quantitatively. Results Neurological sequelae were found in 43%. However, age-appropriate ability to perform daily life activities was normal in all patients. Remarkably, cognitive deficits leading to significant school problems occurred in 19% and behavioral and emotional adjustment disturbances in 27%. In comparison with healthy controls, the survivors rated their HRQoL similarly or even higher. Conclusion Childhood low-grade cerebellar astrocytomas have an excellent cure rate by tumor surgery alone. When compared with other pediatric brain tumors, the risk of neurological, cognitive, emotional, and behavioral complications is relatively small. HRQoL is similar to that of healthy controls.

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Section: Discussionmentioning

confidence: 99%

Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life

et al. 2008

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“…It has also been reported that increased radiation dose leads to incidence of skin toxicity in patients undergoing adjuvant XRT (Weiss, et al, 2003). These effects adds up to some of the other side effects of XRT such as pituitary hormone dysfunction and behaviour problems (HoppeHirsch et al, 1995;Dennis et al, 1996), resulting into diminished therapeutic outcome and poor quality of life among survivors.…”

Section: Synergistic Effect Of Resveratrol and Radiotherapy In Contromentioning

confidence: 99%

Synergistic Effect of Resveratrol and Radiotherapy in Control of Cancers

Kma

2013

Asian Pacific Journal of Cancer Prevention

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Cancers will continue to be a threat to health unless they can be controlled by combinations of treatment modalities. In this review, evaluate the role of resveratrol (RSV) as a radiosensitizing agent was evaluated and underlying mechanisms holistically explored in different cancer models focusing on therapeutic possibilities. The ability of RSV to modify the effect of radiation exposure in normal and cancer cells has indeed been shown quite convincingly, the combination of RSV and IR exhibiting synergistic effects on different cancer cells. This is relevant since controlled exposure to IR is one of the most frequently applied treatments in cancer patients. However, radiotherapy (XRT) treatment regimes are very often not effective in clinical practice as observed in patients with glioma, prostate cancer (PCa), melanoma, for example, largely due to tumour radioresistant properties. Sensitization of IR-induced apoptosis by natural products such as RSV is likely to be relevant in cancer control and treatment. However, all cancers do not respond to RSV+IR in a similar manner. Therefore, for those such as the radioresistant PCa or melanoma cells, the RSV+IR regime has to be very carefully chosen in order to achieve effective and desirable outcomes with minimum toxicity to normal cells. They are reports that the highest concentration of 100 mM RSV and highest dose of 5 Gy IR are sufficient to kill cells by induction of apoptosis, indicating that RSV is effective in radiosensitizing otherwise radioresistant cells. In general, it has been shown in different cancer cells that RSV+XRT effectively act by enhancing expression of anti-proliferative and pro-apoptotic molecules, and inhibiting pro-proliferative and anti-apoptotic molecules, leading to induction of apoptosis through various pathways, and cell death. If RSV+XRT can suppress the signature of cancer stemness, enhance the radiosensitivity by either targeting the mitochondrial functionality or modulating the tumour necrosis factor-mediated or Fas-FasL-mediated pathways of apoptosis in different cancers, particularly in vivo, its therapeutic use in the control of cancers holds promise in the near future.

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“…These children often develop late neurocognitive sequelae, such as significant decreases in intellectual function (1)(2)(3)(4)(5)(6)(7)(8)(9)(10), poor academic performance (6,11,12), and deficits in attention (4,11,13), memory (4,11), verbal fluency (4,5,7,11), and executive functioning (11).…”

Section: Introductionmentioning

confidence: 99%