Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan

Shindo, Akihiro; Ueda, Yukito; Kuzuhara, Shigeki; Kokubo, Yasumasa

doi:10.1186/1471-2377-14-151

Cited by 8 publications

(8 citation statements)

References 30 publications

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“…However, patients also displayed parkinsonian features of bradykinesia, rigidity and tremor. Neuropsychological assessment showed marked abulia, apathy, bradyphrenia and hallucinations 63. Any of the three clinical entities can be the initial presenting feature.…”

Section: Atypical Asian Phenotypesmentioning

confidence: 95%

Amyotrophic lateral sclerosis and motor neuron syndromes in Asia

Shahrizaila

Sobue

Kuwabara

et al. 2016

J Neurol Neurosurg Psychiatry

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While the past 2 decades have witnessed an increasing understanding of amyotrophic lateral sclerosis (ALS) arising from East Asia, particularly Japan, South Korea, Taiwan and China, knowledge of ALS throughout the whole of Asia remains limited. Asia represents >50% of the world population, making it host to the largest patient cohort of ALS. Furthermore, Asia represents a diverse population in terms of ethnic, social and cultural backgrounds. In this review, an overview is presented that covers what is currently known of ALS in Asia from basic epidemiology and genetic influences, through to disease characteristics including atypical phenotypes which manifest a predilection for Asians. With the recent establishment of the Pan-Asian Consortium for Treatment and Research in ALS to facilitate collaborations between clinicians and researchers across the region, it is anticipated that Asia and the Pacific will contribute to unravelling the uncertainties in ALS.

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Section: Atypical Asian Phenotypesmentioning

confidence: 95%

Amyotrophic lateral sclerosis and motor neuron syndromes in Asia

Shahrizaila

Sobue

Kuwabara

et al. 2016

J Neurol Neurosurg Psychiatry

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“…Nonetheless, other diagnostic criteria for apathy have been proposed and used in the assessment of PSP. These being the criteria of Starkstein 32 and those of Robert et al 33 Other studies have used clinical impression and described non-specified criteria: one study described apathy as a “loss of initiative,” 34 and the other described “a disorder of motivation…operationalized as diminished goal oriented behaviour and cognition.” 35…”

Section: Methodsmentioning

confidence: 99%

A Systematic Review of Apathy and Depression in Progressive Supranuclear Palsy

Flavell¹,

Nestor

2021

J Geriatr Psychiatry Neurol

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Depression and apathy can be significant problems in progressive supranuclear palsy (PSP). Using PRISMA guidelines, this systematic review examined prevalence estimates for depression and apathy in PSP, and, how different methods of definition may influence results. 29 studies meeting inclusion/exclusion criteria were identified: 12 on depression, 9 on apathy, and 8 on both. Studies were stratified according to whether a diagnostic criteria, rating scale or screening question methodology was employed. The weighted mean prevalence was 59.7% for depression (sample size = 473) and 58.3% for apathy (sample size = 858). Results for depression using diagnostic criteria or rating scales were similar whereas screening questions were associated with considerable inconsistency. Depression prevalence appeared to be influenced by apathy but not somatic symptoms. Most apathy studies relied only on a screening question method. Depression and apathy are common in PSP but there is a need for consensus on how they are defined (both tools and cut-off scores). In particular, more studies probing apathy in greater detail than a simple screening question are required.

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“…Most authors do not include Lytico-bodig disease as familial ALS. However, this apparently narrowed distribution of this ALS form has also been linked to another form of ALS described in the Kii Peninsula of Japan, also known as Muro disease with a complex neurological phenotype with dementia and movement disorders (including parkinsonism, dystonia and myoclonus), in which TRPM7, C9orf72 and SOD1-related mechanisms have been described 58 .…”

Section: Unclassified Forms Of Familial Alsmentioning

confidence: 96%

Clinical and genetic basis of familial amyotrophic lateral sclerosis

Souza

Pinto

Chieia

et al. 2015

Arq. Neuro-Psiquiatr.

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Amyotrophic lateral sclerosis represents the most common neurodegenerative disease leading to upper and lower motor neuron compromise. Although the vast majority of cases are sporadic, substantial gain has been observed in the knowledge of the genetic forms of the disease, especially of familial forms. There is a direct correlation between the profile of the mutated genes in sporadic and familial forms, highlighting the main role ofC9orf72 gene in the clinical forms associated with frontotemporal dementia spectrum. The different genes related to familial and sporadic forms represent an important advance on the pathophysiology of the disease and genetic therapeutic perspectives, such as antisense therapy. The objective of this review is to signal and summarize clinical and genetic data related to familial forms of amyotrophic lateral sclerosis.

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Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan

Cited by 8 publications

References 30 publications

Amyotrophic lateral sclerosis and motor neuron syndromes in Asia

Amyotrophic lateral sclerosis and motor neuron syndromes in Asia

A Systematic Review of Apathy and Depression in Progressive Supranuclear Palsy

Clinical and genetic basis of familial amyotrophic lateral sclerosis

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