Neuropsychological syndromes in presenile dementia due to cerebral atrophy.

Neary, David; Snowden, J. S.; Bowen, David M.; Sims, Neil R.; Mann, Dave; Benton, J. S.; Northen, B; Yates, P. O.; Davison, Alan

doi:10.1136/jnnp.49.2.163

Cited by 198 publications

(91 citation statements)

References 33 publications

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Section: Discussionmentioning

confidence: 99%

“…Decreased memory has been reported in some studies (Neary et al, 1986;Johansen &. Hagberg, 1989) but not others (Jagustetal., 1989;Miller etal., 1991), while attentional losses have been observed by some investigators (Neary et al, 1986), but not others (Miller et al, 1991). Similarly, evidence for (Jagust et al, 1989;Johansen & Hagberg, 1989) and against (Neary etal., 1986;Miller etal., 1991) the presence of decreased constructional skill, and for (Neary et al, 1987;Jagust et al, 1989) and against (Miller et al, 1991) language (i.e., confrontational naming) disturbance in FTD has also emerged.…”

Section: Discussionmentioning

confidence: 99%

“…Neary et al (1986), Jagust ct al. (1989), andJohansen andHagberg (1989) observed that FTD patients performed more poorly than AD patients in executive function tasks, but better than AD patients in memory, although their reports did not allow statistical verification of group differences.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia

Pachana

Boone

Miller

et al. 1996

J Int Neuropsychol Soc

142

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Neuropsychological changes distinguishing mild Alzheimer's disease (AD) from frontotemporal dementia (FTD) have been described, but empirical verification of differential cognitive characteristics is lacking. Archival neuropsychological data on 15 FTD patients, 16 AD patients, and 16 controls were compared. Controls outperformed both patient groups on measures of verbal and nonverbal memory, executive ability, and constructional skill, with AD patients showing more widespread memory decline. No differences were found between the 3 groups in confrontation naming, recognition memory, or basic attention. Patient groups differed only •n nonverbal memory, with FTD patients performing significantly better than AD patients. However, patient groups also differed in pattern of performance across executive and memory domains. Specifically, AD patients exhibited significantly greater impairment on memory than executive tasks, whereas the opposite pattern characterized the rTD group. These findings suggest that examination of relative rankings of scores across cognitive domains, in addition to interpretation of individual neuropsychological scores, may be useful in differential diagnosis of FTD versus AD. (JINS, 1996, 2, 505-510.)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia

Pachana

Boone

Miller

et al. 1996

J Int Neuropsychol Soc

142

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“…3 In particular, patients who present with a clinical picture suggestive of progressive selective damage to frontal regions of the brain have been shown by cerebral biopsy to have neither pathological nor chemical hallmarks of Alzheimer's disease. 3 The absence of Alzheimer pathology has been confirmed by studies of similar patients at necropsy,4 which have indicated the presence of fronto-temporal atrophy, with or without the specific balloon-like cells pathognomonic of Pick's disease, and has led to the designation "dementia of frontal lobe type" (DFT). In clinically presumed cases of DFT the assumption of frontal lobe dysfunction is supported by brain imaging studies using single photon emission tomography (SPET).'…”

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confidence: 99%

Dementia of frontal lobe type

Neary¹

1998

Neurocase

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“…Clinical patterns similar to those found in AD patients occur also in non-AD patients, highlighting the difficulty of making a definitive diagnosis solely on clinical grounds 18 . Then, some data were not expected from the AD such as: a high protein content (60mg/dl) was found in the CSF from a basal cistern sample, in opposition to the normal CSF usually seen in AD.…”

Section: Discussionmentioning

confidence: 95%

Frontoparietal cortical atrophy with gliosis in the gray matter of cerebral cortex: case report

Brito-Marques

Mello

Montenegro

2002

Arq. Neuro-Psiquiatr.

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-The case of a patient who suffered from progressive amnesia, depressive humor, language and visuospatial disturbances, and hallucination episodies with interference at the daily living activities is reported. She had moderate neuropsichological diffuse deficits at the first examination, especially at the executive and visuo-constructive functions. Her cerebrospinal fluid test presented high total protein. Magnetic resonance image showed slight white matter increase in periventricular, semi-oval center bilateral and left external capsule regions, besides light frontal and parietal lobe atrophy, bilaterally. Brain single photon emission computerized tomography revealed both a bilateral moderate frontal and a severe parietal lobe hypoperfusion, especially on the left side. Macroscopic examination showed cortical atrophy, severe on the frontal, moderate on the parietal and mild on the posterior third temporal lobes, bilaterally. There was a slight atrophy on the neostriatum in the basal ganglia. The histopathological findings of the autopsy showed severe neuronal loss with intensive gemioscytic gliosis and variable degrees of status spongiosus in cortical layer. Hematoxylineosin and Bielschowsky staining did not show neuronal swelling (balooned cell), argyrophilic inclusion (Pick's bodies), neurofibrillary tangles nor senile plaques. Immunohistochemical staining for anti-ubiquitin, anti-tau, anti-β-amyloide, and anti-prion protein were tested negative.KEY WORDS: presenile dementia, cortical gliosis, diffuse neuronal loss, spongiosis, inespecific cortical atrophy.Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso RESUMO -É descrito o caso de uma paciente que apresentava amnésia, humor deprimido, distúrbio de linguagem e visoespacial, e alucinação visual com evolução progressiva, interferindo nas atividades de vida diária. Na primeira avaliação neuropsicológica havia déficit difuso de intensidade moderada, especialmente nas funções executivas e viso-construtivas. O exame de líquido céfalo-raqueano mostrou a taxa de proteína elevada. Ressonância magnética evidenciou leve hiperintensidade de sinal na região periventricular, centro semi-oval bilateral, e alta hiperintensidade de sinal na região da cápsula interna esquerda, além de leve atrofia bilateral nos lobos frontoparietais. Tomografia cerebral por emissão de fóton único revelou hipoperfusão de intensidade moderada nos lobos frontais e severa nos parietais, especialmente à esquerda. Os achados de necrópsia evidenciaram atrofia cortical, sendo severa nos lobos frontais, moderada nos parietais e leve no terço pos...

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Neuropsychological syndromes in presenile dementia due to cerebral atrophy.

Cited by 198 publications

References 33 publications

Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia

Comparison of neuropsychological functioning in Alzheimer's disease and frontotemporal dementia

Dementia of frontal lobe type

Frontoparietal cortical atrophy with gliosis in the gray matter of cerebral cortex: case report

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