Neuropsychological Test Performance to Enhance Identification of Subjects at Clinical High Risk for Psychosis and Be Most Promising for Predictive Algorithms for Conversion to Psychosis

Hauser, Marta; Zhang, Jianping; Sheridan, E. Marcia; Burdick, Katherine E.; Mogil, Rachel; Kane, John M.; Auther, Andrea M.; Carrión, Ricardo; Cornblatt, Barbara A.; Correll, Christoph U.

doi:10.4088/jcp.15r10197

Cited by 75 publications

(75 citation statements)

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“…Not only brain structural alterations but also neurocognitive impairments predate the onset of frank psychosis. Verbal learning and memory are among the most impaired cognitive domains in ARMS (Hauser et al., ; Studerus, Papmeyer, & Riecher‐Rössler, ) as well as FEP patients (Fatouros‐Bergman, Cervenka, Flyckt, Edman, & Farde, ) and may potentially be useful for the early detection and intervention of these disorders (Fusar‐Poli, Deste, et al., ). The California Verbal Learning Test (CVLT) is a test used for the assessment of a wide variety of verbal learning and memory measures and may be applied over a vast area of disorders such as dementia and Alzheimer's disease, traumatic brain injuries, brain lesions, schizophrenia and many more (Delis, Freeland, Kramer, & Kaplan, ; Jacobs & Donders, ).…”

Section: Introductionmentioning

confidence: 99%

No associations between medial temporal lobe volumes and verbal learning/memory in emerging psychosis

Egloff

Lenz

Studerus

et al. 2019

Eur J of Neuroscience

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Grey matter (GM) volume alterations have been repeatedly demonstrated in patients with first episode psychosis (FEP). Some of these neuroanatomical abnormalities are already evident in the at‐risk mental state (ARMS) for psychosis. Not only GM alterations but also neurocognitive impairments predate the onset of frank psychosis with verbal learning and memory (VLM) being among the most impaired domains. Yet, their interconnection with alterations in GM volumes remains ambiguous. Thus, we evaluated associations of different subcortical GM volumes in the medial temporal lobe with VLM performance in antipsychotic‐naïve ARMS and FEP patients. Data from 59 ARMS and 31 FEP patients, collected within the prospective Früherkennung von Psychosen study, were analysed. Structural T1‐weighted images were acquired using a 3 Tesla magnetic resonance imaging scanner. VLM was assessed using the California Verbal Learning Test and its factors Attention Span, Learning Efficiency, Delayed Memory and Inaccurate Memory. FEP patients showed significantly enlarged volumes of hippocampus, pallidum, putamen and thalamus compared to ARMS patients. A significant negative association between amygdala and pallidum volume and Attention Span was found in ARMS and FEP patients combined, which however did not withstand correction for multiple testing. Although we found significant between‐group differences in subcortical volumes and VLM is among the most impaired cognitive domains in emerging psychosis, we could not demonstrate an association between low performance and subcortical GM volumes alterations in antipsychotic‐naïve patients. Hence, deficits in this domain do not appear to stem from alterations in subcortical structures.

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Section: Introductionmentioning

confidence: 99%

No associations between medial temporal lobe volumes and verbal learning/memory in emerging psychosis

Egloff

Lenz

Studerus

et al. 2019

Eur J of Neuroscience

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“…ARMS patients are exposed to a high risk of developing frank psychosis, with transition risks up to 36% after 3 years of follow-up (Fusar-Poli et al, 2012a). Previous studies showed that not only positive psychotic symptoms such as hallucinations, delusions and thought disorders, but also negative symptoms (Cotter et al, 2014) and cognitive impairments (for meta-analysis see Hauser et al, 2017) are frequently present in ARMS patients.…”

Section: Introductionmentioning

confidence: 99%

“…Apart from positive and negative symptoms, cognitive impairments are regarded as a core feature of psychosis and are present in a considerable number of ARMS and FEP patients (Hauser et al, 2017). Although less severe than in FEP patients, ARMS patients show significant and widespread impairments in different domains of cognitive functioning such as general intelligence, attention/vigilance, verbal learning, visual learning, social cognition, executive functioning, processing speed, verbal fluency, working memory and verbal and visual memory (Fusar-Poli et al, 2012b;Hauser et al, 2017). It has been shown that ARMS patients with later transition to psychosis perform significantly worse in cognitive tasks than patients without later transition in nearly all cognitive domains (Hauser et al, 2017;Riecher-Rössler and Studerus, 2017;Studerus et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Although less severe than in FEP patients, ARMS patients show significant and widespread impairments in different domains of cognitive functioning such as general intelligence, attention/vigilance, verbal learning, visual learning, social cognition, executive functioning, processing speed, verbal fluency, working memory and verbal and visual memory (Fusar-Poli et al, 2012b;Hauser et al, 2017). It has been shown that ARMS patients with later transition to psychosis perform significantly worse in cognitive tasks than patients without later transition in nearly all cognitive domains (Hauser et al, 2017;Riecher-Rössler and Studerus, 2017;Studerus et al, 2016). In longitudinal studies, cognitive impairments at baseline predicted poor social, role and occupational outcome (Cotter et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

Leanza

Egloff

Studerus

et al. 2018

Psychiatry Research

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Negative symptoms and neurocognitive performance have been reported to be negatively associated in patients with emerging psychosis. However, most previous studies focused on patients with frank psychosis and did not differentiate between subdomains of negative symptoms. Hence, we aimed to elucidate the specific relationship between negative symptoms and cognitive functioning in patients at clinical high risk (CHR) for psychosis. Data from 154 CHR patients collected within the prospective Früherkennung von Psychosen (FePsy) study were analyzed. Negative symptoms were assessed with the Scale for the Assessment of Negative Symptoms (SANS) and cognitive functioning with an extensive neuropsychological test battery. Regression analyses revealed significant negative associations between negative symptoms and cognitive functioning, particularly in the domains of nonverbal intelligence and verbal fluency. When analyzing each negative symptom domain separately, alogia and asociality/anhedonia were significantly negatively associated with nonverbal intelligence and alogia additionally with verbal fluency. Overall, our results in CHR patients are similar to those reported in patients with frank psychosis. The strong negative association between verbal fluency and negative symptoms may be indicative of an overlap between these constructs. Verbal fluency might have a strong influence on the clinical impression of negative symptoms (particularly alogia) and vice versa.

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“…The team provides personalized care including case management, psychosocial treatment and medication over 2 years according to the literature (Iyer & Malla, 2014). The patient is referred to another psychiatric service in cases of chronic disease diagnosis such as (Hauser et al, 2017). schizophrenia spectrum disorders or bipolar disorder at the end of the 2 years. Patients without a chronic disorder are informed that they can contact team members in case of symptom exacerbation.…”

Section: Two Years Latermentioning

confidence: 99%

Mobile Intensive Care Unit: A case management team dedicated to early psychosis in France

Lecardeur

Meunier-Cussac

Dollfus

2018

Early Intervention Psych

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Neuropsychological Test Performance to Enhance Identification of Subjects at Clinical High Risk for Psychosis and Be Most Promising for Predictive Algorithms for Conversion to Psychosis

Abstract: CHR has mild to moderate globally distributed neuropsychological performance deficits that lie between FEP and HCs. Neuropsychological performance deficits are greater in CHR-P than in CHR-NP, but they overlap, reducing their current utility for risk stratification.

Cited by 75 publications

References 0 publications

No associations between medial temporal lobe volumes and verbal learning/memory in emerging psychosis

No associations between medial temporal lobe volumes and verbal learning/memory in emerging psychosis

The relationship between negative symptoms and cognitive functioning in patients at clinical high risk for psychosis

Mobile Intensive Care Unit: A case management team dedicated to early psychosis in France

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