Neuropsychological testing in presurgical evaluation

Jones‐Gotman, Marilyn; Djordjević, Jelena

doi:10.1002/9781118936979.ch63

Cited by 5 publications

(5 citation statements)

References 111 publications

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“…However, neuro‐psychological outcomes much depend on the tests used. As already demonstrated by Jones‐Gotman in 1993, different epilepsy centres use different tests or test batteries (Jones‐Gotman et al , 1993) and recent reviews suggest that this has not changed since then. At best, one can make recommendations as to which tests should be used for neuropsychological assessment in epilepsy patients.…”

Section: Living In a Different Test Universementioning

confidence: 97%

Cognitive outcomes of different surgical approaches in temporal lobe epilepsy

Helmstaedter¹

2013

Epileptic Disorders

165

108

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Epilepsy surgery is a successful treatment option for pharmacoresistant focal symptomatic epilepsies. However, cognitive impairment is very common in epilepsy patients and may be negatively or positively affected by surgery. Amidst the long-standing discussion of whether a particular surgical approach for temporal lobe epilepsy patients may be superior with regards to seizure control, a recent meta-analysis indicated that this is the case for more extended resections. Larger temporal lobe resections, however, raise concerns that more unaffected and functional tissues may be involved, thus causing worse cognitive outcome. This review is based on published reports collected over a long period, with changing diagnostics and surgical methods, and focuses mainly on the experiences of one epilepsy centre. The review highlights the effects of standard versus selective surgery, the different surgical approaches in selective surgery, determinants other than surgery which may affect cognitive outcome, and the methodologically-important question of outcome assessment and how neuropsychological test selection may bias the result. Overall, from a neuropsychological point of view, individual and selective surgery is preferred in which the aim is to achieve seizure control with minimal effect on the functional integrity of tissues or fibre tracts. Cognition is important for the functions of everyday life and this should be kept in mind, irrespective of which kind of surgery is preferred.

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Section: Living In a Different Test Universementioning

confidence: 97%

Cognitive outcomes of different surgical approaches in temporal lobe epilepsy

Helmstaedter¹

2013

Epileptic Disorders

165

108

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“…The National Institutes of Health (NIH) Common Data Elements for neuropsychology also represent a step towards harmonization for U.S.-based clinical trials (Loring et al, 2011). While harmonization surveys date back nearly 30 years (Jones-Gotman & Zatorre, 1993), test consensus remains aspirational with the complications of diverse languages and cross-cultural nuances aptly recognized (Ho & Lee, 2011), even within the U.S. Thus, while there is general international consensus regarding the indications for neuropsychological assessment in routine and surgical care and the cognitive domains that should be assessed (Baxendale et al, 2019;Wilson et al, 2015), epilepsy has not been able to reach the goal of an evidence-based consensus of psychometric tests, as has been the case in other disorders, such as multiple sclerosis (Benedict et al, 2002;Benedict et al, 2012;Langdon et al, 2012), Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS; Bottiggi et al, 2007;Butters et al, 1990), schizophrenia (Kern et al, 2008;Nuechterlein et al, 2008), vascular dementia (Wilcock et al, 2021), stroke (Hachinski et al, 2006), and Alzheimer's Disease (Weintraub et al, 2018).…”

mentioning

confidence: 99%

Development and application of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE): Initial results from a multi-center study of adults with temporal lobe epilepsy.

McDonald¹,

Busch²,

Reyes³

et al. 2023

Neuropsychology

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Objective: To describe the development and application of a consensus-based, empirically driven approach to cognitive diagnostics in epilepsy research-The International Classification of Cognitive Disorders in Epilepsy (IC-CoDE) and to assess the ability of the IC-CoDE to produce definable and stable cognitive phenotypes in a large, multi-center temporal lobe epilepsy (TLE) patient sample. Method: Neuropsychological data were available for a diverse cohort of 2,485 patients with TLE across seven epilepsy centers. Neuropsychology

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“…• Typical hierarchical flow of information from sensation to cognition is compromised in TLE 11 administered by certified clinical neuropsychologists (V.S. and J.C).…”

Section: Keypointsmentioning

confidence: 99%

Atypical functional connectome hierarchy impacts cognition in temporal lobe epilepsy

et al. 2021

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Objective: Drug-resistant temporal lobe epilepsy (TLE) is typically associated with hippocampal pathology. However, widespread network alterations are increasingly recognized and suggested to perturb cognitive function in multiple domains. Here we tested (1) whether TLE shows atypical cortical hierarchical organization, differentiating sensory and higher order systems; and (2) whether atypical hierarchy predicts cognitive impairment. Methods:We studied 72 well-characterized drug-resistant TLE patients and 41 healthy controls, statistically matched for age and sex, using multimodal magnetic resonance imaging analysis and cognitive testing. To model cortical hierarchical organization in vivo, we used a bidirectional stepwise functional connectivity analysis tapping into the differentiation between sensory/unimodal and paralimbic/transmodal cortices. Linear models compared patients to controls.Finally, we assessed associations of functional anomalies to cortical atrophy and microstructural anomalies, as well as clinical and cognitive parameters.Results: Compared to controls, TLE presented with bidirectional disruptions of sensory-paralimbic functional organization. Stepwise connectivity remained segregated within paralimbic and salience networks at the top of the hierarchy, and sensorimotor and dorsal attention at the bottom. Whereas paralimbic segregation was associated with atypical cortical myeloarchitecture and hippocampal atrophy, dysconnectivity of sensorimotor cortices reflected diffuse cortical thinning. The degree of abnormal hierarchical organization in sensory-petal streams covaried, with broad cognitive impairments spanning sensorimotor, attention, fluency, and visuoconstructional ability and memory, and was more marked in patients with longer disease duration and Engel I outcome.

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Neuropsychological testing in presurgical evaluation

Cited by 5 publications

References 111 publications

Cognitive outcomes of different surgical approaches in temporal lobe epilepsy

Cognitive outcomes of different surgical approaches in temporal lobe epilepsy

Development and application of the International Classification of Cognitive Disorders in Epilepsy (IC-CoDE): Initial results from a multi-center study of adults with temporal lobe epilepsy.

Atypical functional connectome hierarchy impacts cognition in temporal lobe epilepsy

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