Neuroradiologic aspects of West syndrome

Aydınli̇, Nur; Çalışkan, Mine; Özmen, Meral; Tonguç, Erdem

doi:10.1016/s0887-8994(98)00058-7

Cited by 19 publications

(12 citation statements)

References 19 publications

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“…A study on neuroradiological aspects of infantile spasm in patients also reported normal computerized tomography (CT) in 17% and normal magnetic resonance imaging (MRI) in 18% (22), while in our study it was abnormal in3 6 %. Magnetic resonance imaging (MRI) is more informative than tomography (CT) as it demonstrates focal cortical and subcortical lesions and white matter lesions better and may also help in prognostication of motor outcome in these cases (23).…”

Section: Discussionsupporting

confidence: 44%

Clinical Profile of Infants with Hypsarrhythmia

Khreisat

2011

Acta Inform Med

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Objective:The present study was done in order to obtain a baseline profile of infantile spasms and associated neurological disorders.Patient and methods:The study included 50 patients with infantile spasm in Queen Rania Hospital for children in Jordan. The following data were obtained: sex, age at onset of spasms, details of seizure, family history of epilepsy, significant pre-/peri/ post-natal insults, Electroencephalography and detailed neuro imaging evaluation , detailed neurological, neuro developmental ,assessment were done by. Broad categories of possible etiologies were used the results were recorded for further study.Results:Age of onset of infantile spasms ranged from 1month to 1 year and 6 months , (mean 4.8 months). The mean time of presentation was 9.4 months . A male preponderance was noted (74 %). flexor spasms (52%) was the commonest . Other types of seizures also accompanied infantile spasm in 44% children . (84%) were born of normal delivery, History of birth asphyxia was obtained in 48%, 3 (6%) had positive family history Developmental delay was recognized prior to onset of spasms in 52%, microcephaly was the commonest associated problem, Imaging studies of the brain revealed abnormality in 18 patients. 78% patients were classified as symptomatic and 22 % as cryptogenic.Conclusion:the pattern of infantile spasm in our country do not differ from that of developed countries, further researches is required to prevent both chronic epilepsy and psychomotor retardation and .preventive measurement to prevent birth asphyxia is recommended.

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Section: Discussionsupporting

confidence: 44%

Clinical Profile of Infants with Hypsarrhythmia

Khreisat

2011

Acta Inform Med

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“…18 A finding unavailable in the relevant literature, however, and thus of special interest, was the presence of dysgenesis accompanying cranial MRI changes owing to rubella infection, as was confirmed by specific laboratory tests (see Figure 2). As a result of purulent or tuberculous meningitis and herpes simplex encephalitis, which have previously been reported as etiologic factors in infantile spasms, 9,10,14 porencephaly, encephalomalacia, ventricular enlargement, thalamic and putaminal lesions, and cerebellar cortical hemorraghic changes have been encountered in the cranial MRIs of our patients, in addition to calcifications attributable to intrauterine infections, as mentioned above.…”

Section: Discussionsupporting

confidence: 77%

“…[8][9][10] In addition to cranial MRI changes related to hypoxic damage in 30.1% of our patients, 7 patients in this group showed additional lesions indicating changes secondary to (possibly perinatal) hypoglycemia. Periventricular leukomalacia reflecting hypoxic damage in infants with premature delivery, a previously reported condition related to the etiology of infantile spasms, 11,12 was present in 4 cases in our patient population.…”

Section: Discussionmentioning

confidence: 93%

Magnetic Resonance Imaging Findings in Infantile Spasms: Etiologic and Pathophysiologic Aspects

2003

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An etiologic evaluation of 86 patients with infantile spasms is presented and the place of cranial magnetic resonance imaging (MRI) findings within this spectrum is discussed. A total of 103 cranial MRIs, performed between 4 and 72 months of age, were analyzed and classified according to the etiologic and pathophysiologic aspects. Ninety-one percent of cases were diagnosed as symptomatic infantile spasms, and hypoxic-ischemic encephalopathy was the primary cause (30%). The most common involvement was thinning of the corpus callosum in 43 patients (50%), followed by dilation of cerebral ventricles in 32 (36%), delayed myelination in 23 (26.7%), lesions of diencephalic deep gray matter in 17 (19.7%), and enlargement of the subarachnoid space in 12 (14%). Thin corpus callosum and diffuse atrophy were changes mainly associated with hypoxic-ischemic encephalopathy, whereas delayed myelination seemed to be independent from a specific etiology. The results showed that cranial MRI may provide considerable information regarding not only the etiology but also the pathophysiology of infantile spasms.

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“…There are no class I or class II imaging studies in children with IS. Among class III and IV studies, 40–50% of patients showed clear migration abnormalities or syndromes, and 20% showed nonspecific abnormalities (e.g., atrophy) (Aydinli et al., 1998; Saltik et al., 2003). Early imaging is important to assist with etiologic differential diagnosis.…”

Section: Patient Evaluation and Diagnostic Workupmentioning

confidence: 99%

Infantile spasms: A U.S. consensus report

et al. 2010

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SUMMARYThe diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician. Although an evidence-based practice guideline with full literature review was published in 2004, diversity in IS evaluation and treatment remains and highlights the need for further consensus to optimize outcomes in IS. For this purpose, a working group committed to the diagnosis, treatment, and establishment of a continuum of care for patients with IS and their families-the Infantile Spasms Working Group (ISWG)-was convened. The ISWG participated in a workshop for which the key objectives were to review the state of our understanding of IS, assess the scientific evidence regarding efficacy of currently available therapeutic options, and arrive at a consensus on protocols for diagnostic workup and management of IS that can serve as a guide to help specialists and general pediatricians optimally manage infants with IS. The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first-line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification. Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS.

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Neuroradiologic aspects of West syndrome

Cited by 19 publications

References 19 publications

Clinical Profile of Infants with Hypsarrhythmia

Clinical Profile of Infants with Hypsarrhythmia

Magnetic Resonance Imaging Findings in Infantile Spasms: Etiologic and Pathophysiologic Aspects

Infantile spasms: A U.S. consensus report

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