Neuroreceptor Profile and Behavior of CD-1 Mice Subpopulations with Different Attention Stability

Objective: To study the morphofunctional features of the brain development of 14- and 30-day-old rats born in broods that differ significantly in numbers.Methods: 2 age groups of animals were studies – 14-day-old and 30-day-old rat pups, the offspring of intact rats, each group was divided into subgroups: 1) small broods (4-7 rat pups per brood) and 2) broods of average size (9-12 rats in a brood). The brains of animals of both subgroups were subjected to morphometric and histochemical studies. At the age of 28 days, rat pups from the second age group were tested in an elevated plus maze.Results: It was found that rat pups from small broods at the age of 14 and 30 days had signs of acceleration and differed in the outstripping rates of development of brain from animals from the group of broods of average size. Differences were manifested by a greater mass of the brain and hemisphere, a lower numerical density of neurons and a higher density of gliocytes, a large glioneural index, as well as the size of neurons, their nuclei and nucleoli in the cortex of the parietal lobe and the hippocampus. The behavior of pups from small broods and broods of average numbers at the age of 28 days in an elevated plus maze had significant intergroup differences.Conclusions: These findings indicate that differences in brood numbers affect important indicators of brain development.

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Some features of the brain of Wistar rats that developed in broods of various numbers

Zhilnikov

Ryzhavskii

2022

Tihookeanskij medicinskij žurnal

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Effect of phenibut and atomoxetine on the biosynthesis and metabolism of dopamine and serotonin in the brain of C57BL/6 mice

Sukhorukova

Кудрин

Narkevich

et al. 2021

Fk&Fd

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Аннотация. Методом ВЭЖХ/ЭД изучено влияние внутрибрюшинного введения ноотропного средства фенибута (70 мг/кг) и атомоксетина гидрохлорида (3 мг/кг) на нейрохимические показатели дофамин-и серотонинергических систем в структурах мозга мышей C57BL/6. Установлено, что в условиях in vivo блокады декарбоксилазы L-ароматических аминокислот (ДААК) оба препарата в выбранных дозах не оказывали прямого действия на процессы биосинтеза как дофамина, так и серотонина в префронтальной коре и стриатуме грызунов. Обнаруженные эффекты фенибута и атомоксетина гидрохлорида в сравнении с использованными лигандами D 2 -рецепторов квинпиролом (0,1 мг/кг) и сульпиридом (25 мг/кг) позволяют предположить отсутствие прямого участия в них дофаминовых ауторецепторов, регулирующих функциональную активность дофаминергических синапсов.

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Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder

Sukhorukova

Васильева

Kondrakhin

et al. 2022

Fk&Fd

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Effect of Pantogam active subchronic administration (200 mg/kg/day, i.p.) on the behavior of outbred CD-1 mice in the experimental model of attention deficit disorder was studied in the "closed enriched cross maze" test. Pantogam active corrected the initial attention deficit of ED-low rodents subpopulation without changing other parameters of their behavior. Analysis of the results of radioligand binding revealed statistically significant differences in the distribution of D2 and GABAB-receptors in the brain structures of outbred CD-1 mice subpopulations. In the prefrontal cortex (PFC) of ED-low control group with reduced attention level, compared with ED-high control, density of D2 receptors was higher by 18 %, while density of GABAB receptors was lower by 35 %. Administration of pantogam active resulted in decreasing of D2 receptors density by 23 % and increasing of this indicator by 42 % for GABAB- receptors in the PFC of ED-low animals, respectively. Thus, this studied drug has potential efficacy in treating attention deficit in experimental animals, normalizes behavior and possible molecular markers of this pathology.

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Neuroreceptor Profile and Behavior of CD-1 Mice Subpopulations with Different Attention Stability

Cited by 4 publications

References 21 publications

Some features of the brain of Wistar rats that developed in broods of various numbers

Some features of the brain of Wistar rats that developed in broods of various numbers

Effect of phenibut and atomoxetine on the biosynthesis and metabolism of dopamine and serotonin in the brain of C57BL/6 mice

Effects of pantogam active on behavior and neuroreceptor spectrum in mouse model of attention deficit disorder

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