“…Various nonoperative interventions are available for nonspecific low back pain treatment, in which lifestyle modification, education, superficial heat, and some nonpharmacological therapy, including exercise and cognitive behavioral therapy, are considered the first-line treatment, while other nonpharmacological therapy and pharmacological therapy, both oral and systemic, are used as second-line or adjunctive treatments [18]. There are several nonpharmacological therapies with promising outcomes for nonspecific low back pain, such as massage [19], acupuncture [20,21], yoga [22], and interdisciplinary rehabilitation, including biopsychosocial rehabilitation [23,24], combined chiropractic [25], therapeutic ultrasound [26], radiofrequency denervation [27], neuroreflexotherapy [28], extracorporeal shockwave therapy [29][30][31], laser therapy [32][33][34], and neuromodulation [35][36][37]. For pharmacological therapies, nonsteroidal anti-inflammatory drugs (NSAIDs) [38][39][40], muscle relaxants [41], intra-articular facet joint injection [42], and herbal medicine, including C. frutescens (Cayenne), H. procumbens, S. alba, S. officinale L., S. chilensis, and lavender essential oil, have shown significant benefits for nonspecific LBP [43].…”