Neurorehabilitation and apps: A systematic review of mobile applications

Rodríguez, María Teresa; Vázquez, Susana Collado; Martín‐Casas, Patricia; Cuerda, Roberto Cano de la

doi:10.1016/j.nrleng.2015.10.002

Cited by 24 publications

(29 citation statements)

References 15 publications

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“…43 Non-specialist or lay community health workers, school teachers, community leaders, and private and non-governmental actors can all be engaged in strengthening coverage of care, by providing awareness and facilitating the early identification and detection of people with neurological disorders. 42,[44][45][46][47][48][49] For example, a four-staged treatment delivery model for epilepsy in tribal areas of the Indian State of Jharkhand has shown that voluntary health workers from the community can be effectively trained to identify people with epilepsy and persuade them to seek treatment. 50 Introducing home-based care interventions also has the potential to improve treatment adherence, reduce costs of care, and improve overall quality of life.…”

Section: Discussionmentioning

confidence: 99%

The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019

Singh¹,

Sharma²,

Kumar³

et al. 2021

The Lancet Global Health

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Background A systematic understanding of the burden of neurological disorders at the subnational level is not readily available for India. We present a comprehensive analysis of the disease burden and trends of neurological disorders at the state level in India.Methods Using all accessible data from multiple sources, we estimated the prevalence or incidence and disabilityadjusted life-years (DALYs) for neurological disorders from 1990 to 2019 for all states of India as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. We assessed the contribution of each neurological disorder to deaths and DALYs in India in 2019, their trends in prevalence or incidence and DALY rates over time, and heterogeneity between the states of India. We also assessed the Pearson correlation coefficient between Sociodemographic Index (SDI) of the states and the prevalence or incidence and DALY rates of each neurological disorder. Additionally, we estimated the contribution of known risk factors to DALYs from neurological disorders. We calculated 95% uncertainty intervals (UIs) for the mean estimates. Findings The contribution of non-communicable neurological disorders to total DALYs inIndia doubled from 4•0% (95% UI 3•2-5•0) in 1990 to 8•2% (6•6-10•2) in 2019, and the contribution of injury-related neurological disorders increased from 0•2% (0•2-0•3) to 0•6% (0•5-0•7). Conversely, the contribution of communicable neurological disorders decreased from 4•1% (3•5-4•8) to 1•1% (0•9-1•5) during the same period. In 2019, the largest contributors to the total neurological disorder DALYs in India were stroke (37•9% [29•9-46•1]), headache disorders (17•5% [3•6-32•5]), epilepsy (11•3% [9•0-14•3]), cerebral palsy (5•7% [4•2-7•7]), and encephalitis (5•3% [3•7-8•9]). The crude DALY rate of several neurological disorders had considerable heterogeneity between the states in 2019, with the highest variation for tetanus (93•2 times), meningitis (8•3 times), and stroke (5•5 times). SDI of the states had a moderate significant negative correlation with communicable neurological disorder DALY rate and a moderate significant positive correlation with injury-related neurological disorder DALY rate in 2019. For most of the noncommunicable neurological disorders, there was an increase in prevalence or incidence from 1990 to 2019. Substantial decreases were evident in the incidence and DALY rates of communicable neurological disorders during the same period. Migraine and multiple sclerosis were more prevalent among females than males and traumatic brain injuries were more common among males than females in 2019. Communicable diseases contributed to the majority of total neurological disorder DALYs in children younger than 5 years, and non-communicable neurological disorders were the highest contributor in all other age groups. In 2019, the leading risk factors contributing to DALYs due to noncommunicable neurological disorders in India included high systolic blood pressure, air pollution, dietary risks, high fasting plasma glucose, and h...

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Section: Discussionmentioning

confidence: 99%

The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019

Singh¹,

Sharma²,

Kumar³

et al. 2021

The Lancet Global Health

View full text Add to dashboard Cite

show abstract

“…Asynchronous telemedicine interventions refer to the "store-and-forward" technologies, which allow monitoring and collection of physiological and/or behavioral data through wearable or implantable devices connected to an online or virtual platform and then sending the information to a clinical center for review and consultation (88,89). The most common technological solutions used to provide telemedicine interventions are smartphones, tablets, and wearable sensors (90), including digital applications for self-exercises or monitoring the behavioral or physiological state of the patients (91). However, in the last 20 years, some telemedicine interventions have integrated the use of virtual reality (VR) platforms to deliver personalized rehabilitation training or clinical interventions at a distance (92)(93)(94).…”

Section: Technological Solutions For Telemedicinementioning

confidence: 99%

Telemedicine and Virtual Reality at Time of COVID-19 Pandemic: An Overview for Future Perspectives in Neurorehabilitation

et al. 2021

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In catastrophic situations such as pandemics, patients' healthcare including admissions to hospitals and emergency services are challenged by the risk of infection and by limitations of healthcare resources. In such a setting, the use of telemedicine interventions has become extremely important. New technologies have proved helpful in pandemics as a solution to improve the quality of life in vulnerable patients such as persons with neurological diseases. Moreover, telemedicine interventions provide at-home solutions allowing clinicians to telemonitor and assess patients remotely, thus minimizing risk of infection. After a review of different studies using telemedicine in neurological patients, we propose a telemedicine process flow for healthcare of subjects with chronic neurological disease to respond to the new challenges for delivering quality healthcare during the transformation of public and private healthcare organizations around the world forced by COVID-19 pandemic contingency. This telemedicine process flow represents a replacement for in-person treatment and thereby the provision equitable access to the care of vulnerable people. It is conceptualized as comprehensive service including (1) teleassistance with patient counseling and medical treatment, (2) telemonitoring of patients' health conditions and any changes over time, as well as (3) telerehabilitation, i.e., interventions to assess and promote body functions, activities, and consecutively participation. The hereby proposed telemedicine process flow could be adopted on a large scale to improve the public health response during healthcare crises like the COVID-19 pandemic but could equally promote equitable health care independent of people's mobility or location with respect to the specialized health care center.

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“…Many studies have shown that organ injury induced by cisplatin is mainly related to the accumulation of active oxygen and the generation of peroxidation in the tissues [21], which is primarily manifested as an increase in MDA, GSH, and activity of various antioxidant enzymes decreased [22,23]. It's worth noting that some researches have indicated that P38MAPK activated by cisplatin is the main signal transduction pathway causing toxic reactions [24].…”

Section: Discussionmentioning

confidence: 99%

Curcumin Promotes Anti-Tumor Effect of Cisplatin and Protects Against Cisplatin-Induced Kidney Injury in Lung Cancer

Zhao

et al. 2021

Preprint

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Background: Lung cancer patients will develop strong drug resistance and serious complications, especially severe renal injuries, after long-term treatment of platinum-based drugs. Curcumin (Cur) combined with cisplatin (DDP) has a synergistic and attenuating effect on lung cancer. However, the role of curcumin in protection against DDP kidney injury in lung cancer remains unknown. Methods: We conducted in vitro experiments to evaluate the anti-tumor effect of cur combined with DDP such as MTT, mitochondrial membrane potential (ΔΨm) analysis, and flow cytometry. The serology and histopathology were used to assess kidney injury induced by DDP in vivo experiments. Western blotting analysis was utilized to detect P38 levels in mouse kidneys. Results: A significant synergistic antitumor effect in A549 and LLC-1 cells based on the activation of the mitochondrial apoptosis pathway. Moreover, Cur could reduce the nephrotoxicity of DDP treatment through the P38MAPK signaling pathway. Conclusion: Cur in combination with DDP may be considered as a beneficial combination regimen for enhancing DDP sensitivity and providing a promising renoprotective effect against nephrotoxicity induced by DDP.

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Neurorehabilitation and apps: A systematic review of mobile applications

Cited by 24 publications

References 15 publications

The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019

The burden of neurological disorders across the states of India: the Global Burden of Disease Study 1990–2019

Telemedicine and Virtual Reality at Time of COVID-19 Pandemic: An Overview for Future Perspectives in Neurorehabilitation

Curcumin Promotes Anti-Tumor Effect of Cisplatin and Protects Against Cisplatin-Induced Kidney Injury in Lung Cancer

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