Neurosarcoïdose

Concomitant axillary mycobacteriosis and neuro-sarcoidosis: diagnostic pitfalls

“…Incidence of neuro-sarcoidosis is estimated between 5 and 25%11 21–23 but only 10 % of these patients have no other localisation 14. It is twice as high in series of autopsies,13 remaining without clinical manifestations in many cases.…”

“…Extrathoracic localisations occur in about 20%11 and up to 50% in older patients,12 their incidence being yet higher in series of autopsies 13 14. All tissues and organs may be affected.…”

“…It is twice as high in series of autopsies,13 remaining without clinical manifestations in many cases. It is presented as meningitis, invasion of the hypothalamus, the pituitary gland or cranial nerves, or as tumour lesions 13 14 22–24. Clinical expression is very polymorphous, with numerous non-specific symptoms25 such as isolated psychiatric symptoms comprising dementia or asthenia 23 24 26.…”

“…Clinical expression is very polymorphous, with numerous non-specific symptoms25 such as isolated psychiatric symptoms comprising dementia or asthenia 23 24 26. Magnetic resonance neurography is contributive less by specificity than by localisation of neuro-sarcoidosis lesions 14 21 23. ACE in CSF is elevated in only 33 to 58% of cases 11 14.…”

“…Magnetic resonance neurography is contributive less by specificity than by localisation of neuro-sarcoidosis lesions 14 21 23. ACE in CSF is elevated in only 33 to 58% of cases 11 14. Differential diagnosis includes lymphoma, vasculitis, Whipple’s disease, Lyme borreliosis and tuberculosis 11 14 23 26.…”