Neurosarcoidosis

Abstract

Although neurosarcoidosis seems to occur in only 5% to 10% of patients who have sarcoidosis, it may lead to significant complications. The diagnosis of neurosarcoidosis usually relies on indirect information from imaging and spinal fluid examination. Although MR imaging remains the most sensitive technique for detecting neurologic disease, other tests, including positron emission tomography scanning and cerebral spinal fluid examination, can provide important information. The role of immunosuppressive agents such as methotrexate, cyclophosphamide, and azathioprine has been expanded, and these agents should be considered for the treatment of some manifestations of neurosarcoidosis. Reports of the antitumor necrosis factor agent infliximab suggest that this drug can be helpful for patients who have neurosarcoidosis.

Isolated spinal neurosarcoidosis: an autopsy case

“…Neurosarcoidosis is recognized in 5-10% of cases of systemic sarcoidosis. [1][2][3] Neurosarcoidosis without the involvement of other organs is very rare. 1-3 The present case was isolated spinal neurosarcoidosis, which is an extremely rare …”

“…Neurosarcoidosis occurs in 5-10% of patients with sarcoidosis. [1][2][3] Neurosarcoidosis occurs preferentially in the brain. [1][2][3] Spinal neurosarcoidosis is relatively rare compared with brain neurosarcoidosis.…”

“…[1][2][3] Neurosarcoidosis occurs preferentially in the brain. [1][2][3] Spinal neurosarcoidosis is relatively rare compared with brain neurosarcoidosis. [1][2][3] In addition, isolated spinal neurosarcoidosis sparing other organs is very rare.…”

“…[1][2][3] Spinal neurosarcoidosis is relatively rare compared with brain neurosarcoidosis. [1][2][3] In addition, isolated spinal neurosarcoidosis sparing other organs is very rare. [4][5][6] Furthermore, autopsy cases of isolated spinal sarcoidosis are extremely rare or none.…”

Neurological Symptoms of Sarcoidosis-induced Small Fiber Neuropathy Effectively Relieved with High-dose Steroid Pulse Therapy

“…Neurological complications of sarcoidosis occur in approximately 5% of patients and are well described to cause cranial nerve disorders (neurosarcoidosis) and peripheral neuropathy by affecting large nerve fibers (2,3). Recently, small fiber neuropathy (SFN), a subtype of peripheral neuropathy that selectively involves thinly myelinated Aδ fibers and unmyelinated C fibers, has been recognized to be present in over 40% of patients with sarcoidosis (4).…”