Neurosarcoidosis Mimicking Meningioma

Rodríguez, Fausto J.; Link, Michael J.; Driscoll, Colin L. W.; Giannini, Caterina

doi:10.1001/archneur.62.1.148

Cited by 14 publications

(3 citation statements)

References 2 publications

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“…Dural involvement is less common, and the presentation of single or multiple, tumor-like, extraaxial masses is fairly unusual, particularly without coexisting extraneural manifestations. 14 In our patient, combined leptomeningeal and dural involvement was present, which is also uncommon. The low rate of occurrence of dural and leptomeningeal disease in the same location can be explained by the presence of arachnoid barrier cells that slow down or prevent the spread of disease through the arachnoid membrane.…”

Section: Discussionmentioning

confidence: 46%

Neurosarcoidosis resembling multiple meningiomas: A misleading presentation of the disease and diagnostic challenge

Switlyk

Niehusmann

Sprauten

et al. 2021

Acta Radiologica Open

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Sarcoidosis is characterized by the presence of noncaseating granulomatous inflammation in the affected organs. Neurosarcoidosis denotes the involvement of the nervous system and can be either isolated or coexisting with extraneural systemic inflammation. The diagnosis of isolated neurosarcoidosis may be challenging due to unspecific symptoms and similar appearances with other disease processes. This report presents an uncommon case of intracranial sarcoidosis mimicking multiple meningiomas. Familiarity with the spectrum of magnetic resonance imaging findings in neurosarcoidosis is crucial to prevent interpretive errors which may in turn lead to an inappropriate diagnosis and treatment.

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Section: Discussionmentioning

confidence: 46%

Neurosarcoidosis resembling multiple meningiomas: A misleading presentation of the disease and diagnostic challenge

Switlyk

Niehusmann

Sprauten

et al. 2021

Acta Radiologica Open

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“…52 Dural involvement by sarcoidosis is less common, but when present, it can resemble a mass lesion with a dural tail, similar to a meningioma. 53 Other diagnoses entertained following dural involvement include lymphomas, metastasis, plasmacytoma, cranial pachymeningitis, granulomatous infections, and post-lumbar puncture low-volume headache. Diffuse white matter involvement of the periventricular areas and less commonly of the brain stem, basal ganglia, and spinal cord can also be detected on MRI, which may resemble lesions seen in other entities such as multiple sclerosis, lymphoma, vasculitis, microvascular disease, and infectious etiologies such as Lyme disease.…”

Section: Imagingmentioning

confidence: 99%

Neurosarcoidosis: Diagnosis and Management

Vargas

Stern

2010

Semin Respir Crit Care Med

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Sarcoidosis is a multisystemic inflammatory granulomatous disease that affects both the central and peripheral nervous system. The neurological manifestations depend on the areas of the neuroaxis affected. In the brain, patients with neurosarcoidosis have leptomeningeal and intraparenchymal infiltration of granulomas that leads to, for example, cranial nerve palsies, basal meningitis, and endocrine dysfunction. It can cause peripheral neuropathies such as mononeuritis multiplex and sensorimotor polyneuropathy as well as radiculopathy and myopathy. Diagnosis and management of patients with neurosarcoidosis are challenging given that the gold standard is tissue-proven biopsy, which, in most cases of neurological illness, is difficult to obtain. Treatment strategies have not been rigorously evaluated but corticosteroids are considered the drug of choice. Other immunosuppressant agents such as cyclophosphamide, mycophenolate mofetil, and infliximab are efficacious in the treatment of neurosarcoidosis.

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“…Infl ammatory pseudotumors with lympho-plasmacellular infl ammation in the region of the Gasserion ganglion have been described in this context [5] as well as pure lymphomas mimicking a trigeminal neurinoma [2] . Other entities include tuberculomas [9] and neurosarcoidosis [1,3,16,19] . Sarcoidosis is a multisystem disorder that usually develops in the respiratory tract and is characterized by non-caseating epitheloid granulomas.…”

Section: Introductionmentioning

confidence: 99%