Neurosecretion of arginine vasopressin by an olfactory neuroblastoma causing reversible syndrome of antidiuresis

Primary Sellar Neuroblastoma Presenting with Syndrome of Inappropriate Secretion of Anti-diuretic Hormone

“…The possibility that euvolaemic hyponatraemia was secondary to low ACTH was also excluded by the normal values of pre-operative plasma ACTH and cortisol and because the hyponatraemia persisted even after replacement with hydrocortisone and thyroxine. Interestingly, neuroblastomas in other locations such as olfactory nerves [19,20], thymus [21,22] have on occasion been described to cause SIADH, even as the sole feature at onset [20]. In two of these cases, ectopic production of ADH in tumour cells was demonstrated by immunohistochemistry [19,21].…”

Thymic Neuroblastoma in Adults:Report of Three Cases With Special Emphasis on Its Association With the Syndrome of Inappropriate Secretion of Antidiuretic Hormone

“…20 A capacity for dual differentiation along these lines in the thymus would explain the case of mixed neuroblastoma and thymic carcinoma reported by Alguacil-Garcia and Halliday. 21 Interestingly, olfactory neuroblastoma, like thymic neuroblastoma, can be associated with SIADH, [22][23][24][25][26][27] whereas classic abdominal neuroblastoma is not. Of note, ADH peptide production has been demonstrated in normal thymic epithelium at the messenger RNA, biochemical, and immunohistochemical levels by using frozen sections.…”

Intraoperative Hypertensive Crisis Due to a Catecholamine-Secreting Esthesioneuroblastoma

“…Other studies have reported secretion of adrenocorticotropic hormone (ACTH) from esthesioneuroblastomas (17)(18)(19)(20)(21)(22)(23)(24) . Syndrome of inappropriate antidiuretic hormone (SIADH) has also been reported in patients with esthesioneuroblastoma (9,(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36) .…”