Neurosteroid influence on affective tone

Walton, Najah; Antonoudiou, Pantelis; Maguire, Jamie

doi:10.1016/j.neubiorev.2023.105327

Cited by 6 publications

(3 citation statements)

References 167 publications

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“…First, a number of genes are associated with depressive disorders, such as variations in the 5-HTT serotonin transporter gene and polymorphisms in the STin2.12 allele [8]; SNPs [9]; clock-controlled genes (CCGs) driven by endogenous molecular clocks that regulate rhythmic expression [31]; SLC6A4, COMT, TPH2, FKBP5, MDD1, HTR2A, and MDD2 as well as methylation in genes BDNF, NR3C1, and OXTR [30]; the CCN gene family with elevated CCN2 and CCN3 expression [28]; deletion of the STS gene [27]; methyl transferase-like 13; chromosomal locations 16p13 and 8q24 [8]; mRNA expression of 5α-reductase type I [25], and PRS folate metabolism (MTHFR C677T) [20]. These genes were found to be mainly associated with PPP, BP, manic symptoms, and major depressive episodes.…”

Section: Genes and Chromosomal Location-genetic And Epigenetic Factorsmentioning

confidence: 99%

“…Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) as well as norepinephrine reuptake inhibitors, have been suggested as effective treatments for PPD and show favorable results in women suffering from BD [29][30][31].…”

Section: Antidepressantsmentioning

confidence: 99%

“…Neuroleptics, such as haloperidol, have been used as treatment options for PPP and BD. However, as haloperidol is an FGA, it is more likely to cause adverse effects; thus, SGA medications are more favorable as a treatment method [31].…”

Section: Neurolepticsmentioning

confidence: 99%

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Genetic and Epigenetic Factors Associated with Postpartum Psychosis: A 5-Year Systematic Review

Tsokkou,

Kavvadas,

Georgaki

et al. 2024

JCM

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Purpose: Postpartum psychosis (PPP) is a serious mental health illness affecting women post-parturition. Around 1 in 1000 women are affected by postpartum psychosis, and the symptoms usually appear within 2 weeks after birth. Postpartum mental disorders are classified into 3 main categories starting from the least to most severe types, including baby blues, postpartum depression, and postpartum psychosis. Materials and Methods: In this systematic review, genetic and epigenetic factors associated with postpartum psychosis are discussed. A PRISMA flow diagram was followed, and the following databases were used as main sources: PubMed, ScienceDirect, and Scopus. Additional information was retrieved from external sources and organizations. The time period for the articles extracted was 5 years. Results: Initially, a total of 2379 articled were found. After the stated criteria were applied, 58 articles were identified along with 20 articles from additional sources, which were then narrowed down to a final total of 29 articles. Conclusions: It can be concluded that there is an association between PPP and genetic and epigenetic risk factors. However, based on the data retrieved and examined, the association was found to be greater for genetic factors. Additionally, the presence of bipolar disorder and disruption of the circadian cycle played a crucial role in the development of PPP.

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