Neurosteroid, Natural and Anabolic Steroids: Physiological, Immunological and Histopathological Study on Diabetic Albino Rats

Abstract

Based on the aforementioned results of the hematological parameters and interleukins (IL-2 & IL-6) improvements after treatment with DHEA. Fasting blood sugar and body weight after Sustanon, and lipid profile after both hydrocortisone and Sustanon. ALP was almost enhanced in all treated groups. Moreover, histopathological examination of kidney, liver and spleen showed numerously distortion.In conclusion; from the obtained results, it can be reported that DHEA administration can improve immunity, reduce oxidative stress associated with diabetes, and ameliorate tissue damage in the kidney and spleen. Hydrocortisone may improve lipid profile, but has negative effects on immunity and tissue health. Sustanon has positive effects on blood glucose and lipid profile, but its effects on immunity is indistinguishable.