Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach

Valerio, Enrico; Stocchero, Matteo; Pirillo, Paola; D’Errico, Ignazio; Bonadies, Luca; Galderisi, Alfonso; Giordano, Giuseppe; Baraldi, Eugenio

doi:10.1016/j.ebiom.2023.104636

Cited by 2 publications

(1 citation statement)

References 57 publications

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“…Metabolomics, the most recent of the -omics sciences, effectively fits within this modern context of care, which is increasingly moving towards individualized treatment of each patient. Metabolomic analysis of urine has already been applied in the neonatal field, particularly for the characterization of conditions such as sepsis [ 9 ], necrotizing enterocolitis [ 10 ], hypoxic-ischemic encephalopathy [ 11 , 12 ], and bronchopulmonary dysplasia [ 13 ]; however, there are currently no studies investigating the effect of antenatal steroid prophylaxis on the neonatal metabolome.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach

Valerio,

Meneghelli,

Stocchero

et al. 2024

IJMS

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We analyzed and compared variations in the urinary metabolome, as well as postnatal clinical outcomes among preterm infants, based on the timing of antenatal corticosteroid (ACS) administration in response to preterm labor onset in their mothers. This was a prospective observational study held in the Neonatal Intensive Care Unit, Department of Woman’s and Child’s Health, Padova University Hospital (Italy). A urine sample was obtained from each patient within 24 h of birth; Mass Spectrometry-based untargeted metabolomics analysis was then conducted. We searched for any significant disparities in the metabolomic profile of preterm newborns subjected to antenatal corticosteroid (ACS) treatment at varying timings; their correlation with clinical outcomes were also evaluated. The group receiving ACS within the optimal time window (1–7 days before delivery) exhibited elevated levels of cysteine, N-acetylglutamine, propionyl carnitine and 5-hydroxyindolacetic acid, coupled with a decrease in pipecolic acid. Clinically, this group demonstrated a reduced need for invasive ventilation (p = 0.04). In conclusion, metabolomics analysis identified several metabolites that discriminated preterm infants whose mothers received ACS within the recommended time window. Elevated levels of cysteine and 5-Hydroxyindoleacetic acid, metabolites characterized by antioxidant and anti-inflammatory properties, were observed in these infants. This metabolic profile correlated with improved respiratory outcomes, as evidenced by a reduced necessity for invasive ventilation at birth.

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Section: Introductionmentioning

confidence: 99%

The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach

Valerio,

Meneghelli,

Stocchero

et al. 2024

IJMS

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Brain Diffusion Changes in Perinatal Asphyxia Cases

Dogan,

Gumus

2024

Nigerian Journal of Clinical Practice

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Background: Prolonged perinatal asphyxia (PA) may cause hypoxic-ischemic damage to the brain. The aim of this study was to investigate the brain diffusion changes of patients with PA and examine the relationship with brain damage. Methods: This retrospective study included 55 patients diagnosed with PA, separated into mild and severe PA groups. For the evaluation of brain damage in all the study neonates, brain and diffusion MRI scans were performed using a 3T device. The scans were taken between 5 and 10 days postnatal, after completion of hypothermia treatment, in accordance with the standard clinical protocol of our institution. Apparent diffusion coefficient (ADC) values of the lentiform nucleus, thalamus, frontal white matter, and posterior limbs of the internal capsule were measured. Minitab package programs and SPSS version 20.0 software were used for statistical analysis and graphic drawing. Spearman’s rank correlation analysis was used. Results: The bilateral lentiform nucleus, thalamus, frontal white matter, and posterior limbs of the internal capsule ADC values were significantly higher in the severe PA group than in the mild PA group. Conclusions: In neonates with severe perinatal asphyxia, brain damage can be evaluated on diffusion-weighted imaging (DWI) of the cerebral deep white matter and basal ganglia. DWI, imaging with conventional brain MRI comes to the fore in clinical importance in PA patients.

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Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach

Cited by 2 publications

References 57 publications

The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach

The Impact of Antenatal Corticosteroids on the Metabolome of Preterm Newborns: An Untargeted Approach

Brain Diffusion Changes in Perinatal Asphyxia Cases

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