Neurosteroids and translocator protein 18 kDa (TSPO) ligands as novel treatment options in depression
Marco Riebel,
Lisa-Marie Brunner,
Caroline Nothdurfter
et al.
Abstract:Recently, the gamma-aminobutyric acid (GABA) system has come into focus for the treatment of anxiety, postpartum depression, and major depressive disorder. Endogenous 3α-reduced steroids such as allopregnanolone are potent positive allosteric modulators of GABAA receptors and have been known for decades. Current industry developments and first approvals by the U.S. food and drug administration (FDA) for the treatment of postpartum depression with exogenous analogues of these steroids represent a major step for… Show more
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