Neurostimulation for tear production

Park, Ji Kwan; Cremers, Sandra Lora; Kossler, Andrea L

doi:10.1097/icu.0000000000000590

Cited by 12 publications

(9 citation statements)

References 26 publications

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“…Consequently, the animal could still retract the eyeball and move the third eyelid when detecting discomfort in the ocular surface, which, in its turn, has as its afferent pathway the trigeminal nerve, which is not affected by auriculopalpebral block (Michou and Leece 2012). The trigeminal nerve, in turn, when stimulated from the ocular surface, is able to induce tear production (Esteves et al 2009;Park et al 2019).…”

Section: Discussionmentioning

confidence: 99%

Effects of auriculopalpebral nerve block on ocular parameters in dogs

et al. 2021

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The objective of this study was to compare the effects of two local anesthetics used on auriculopalpebral block on eyelid akinesia, tear production, intraocular pressure (IOP) and tear break-up time (TBUT) in conscious dogs. A blind, randomized, prospective study was conducted to determine the effects of auriculopalpebral block using ropivacaine 0.75% and bupivacaine 0.5% in 12 healthy non-brachycephalic dogs (24 eyes). Threat response and eyelid reflex tests, Schirmer tear test (STT), IOP and tear break-up time were conducted before blockage and at 30, 60, 120, 240 and 360 minutes after application. A difference was observed between the values found at 30, 60, 120 and 240 minutes compared to baseline for threat response and eyelid reflex tests in the two groups evaluated, proving eyelid akinesia after blockages. No difference was found for STT, IOP and TBUT between baseline values and post-anesthesia times or between groups. It was possible to conclude that ropivacaine and bupivacaine on auriculopalpebral block in conscious dogs promoted eyelid akinesia for at least 240 minutes, not altering ocular physiological parameters of tear production, intraocular pressure, and tear break-up time after blockages.

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Section: Discussionmentioning

confidence: 99%

Effects of auriculopalpebral nerve block on ocular parameters in dogs

et al. 2021

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“…Such stimulation may be experienced as proximal sensations involving tactile feelings on the skin (Stocco et al, 2015;Lee et al, 2017), patterns displayed in the visual field (Caspi et al, 2021), a sense of smell (Holbrook et al, 2019), or specific bodily reactions (e.g. tear production; Park et al, 2019). As these sensations are generated through neural stimulation, they present opportunities for digitally transmitting sensory experiences and addressing long-standing limitations of online services that have struggled to convey tactile, somatosensory, or olfactory sensations (Petit et al, 2019).…”

Section: Conceptualizing Neuro-enhanced Realitymentioning

confidence: 99%

Exploring the frontiers in reality-enhanced service communication: from augmented and virtual reality to neuro-enhanced reality

Hilken

Chylinski

Ruyter

et al. 2022

JOSM

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PurposeThe authors explore neuro-enhanced reality (NeR) as a novel approach for enhancing service communication between customers, frontline employees, and service organizations that extends beyond current state-of-the-art approaches based on augmented reality (AR) and virtual reality (VR) technologies.Design/methodology/approachThe authors first take stock of research on reality-enhanced service communication with AR and VR, then complement these insights with emerging neuroscientific research to conceptualize how NeR enables innovative forms of service communication. On this basis, the authors develop a research agenda to guide the future study and managerial exploitation of NeR.FindingsAR and VR already offer unique affordances for digital-to-physical communication, but these can be extended with NeR. Specifically, NeR supports neuro-to-digital and digital-to-neuro communication based on neuroimaging (e.g. controlling digital content through thought) and neurostimulation (e.g. eliciting brain responses based on digital content). This provides a basis for outlining possible applications of NeR across service settings.Originality/valueThe authors advance knowledge on reality-enhanced service communication with AR and VR, whilst also demonstrating how neuroscientific research can be extended from understanding brain activity to generating novel service interactions.

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“…They determined that ethmoid (afferent) nerve stimulation could increase tearing similar to gland stimulation. Electrical stimulation of the lacrimal gland or afferent nerves can increase tear production [37,63,65].…”

Section: History Of Neurostimulation For Dry Eye Diseasementioning

confidence: 99%

Neurostimulation for dry eye disease

London

Pincovich

Solomon

2022

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewTo review the neuroanatomy and physiology of the basal and reflex tearing and present the available and developing therapies using the concept of neurostimulation in dry eye disease (DED). Recent findingsThe most prevalent current DED treatments seek to supplement low tear volume and tear components or reduce inflammation. Neurostimulation is a unique approach gaining momentum in recent years, geared toward increasing the production of all basal tear components by stimulating the nerves responsible for producing the various tear components. The neuroanatomy of the lacrimal unit provides several possible access points to stimulate tear production through two arms of the sensory trigeminal nerves. Modes of stimulation include chemical or energy in electrical or magnetic form. Research thus far has shown that neurostimulation can achieve lacrimal, goblet cell, and meibomian gland stimulation. Subjectively it improves symptoms of DED. Clinically, neurostimulation has improved the signs and symptoms of DED by increasing basal tear production and tear volume.

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Neurostimulation for tear production

Cited by 12 publications

References 26 publications

Effects of auriculopalpebral nerve block on ocular parameters in dogs

Effects of auriculopalpebral nerve block on ocular parameters in dogs

Exploring the frontiers in reality-enhanced service communication: from augmented and virtual reality to neuro-enhanced reality

Neurostimulation for dry eye disease

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