Neurosurgical Applications of Magnetic Hyperthermia Therapy

Rivera, Daniel; Schüpper, Alexander J.; Bouras, Alexandros; Anastasiadou, Maria; Kleinberg, Lawrence; Kraitchman, Dara L.; Attaluri, Anilchandra; Ivkov, Robert; Hadjipanayis, Constantinos

doi:10.1016/j.nec.2022.11.004

Cited by 11 publications

(9 citation statements)

References 128 publications

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“…Clinically, multiple trials between 1988 and 2019 have shown that numerous sessions of MHT are possible in the brain following a single intracranial delivery of MNPs. Overall, these studies reported that MHT was safe, conferred a survival benefit, and potentially induced an antitumor immune response [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…To date, no long-term adverse effects of AMF or MHT treatment have been reported, and much of the existing data suggest that MHT is an overall safe intervention [ 9 , 10 , 14 , 95 ]. Most AMF generators approved for use in MHT produce MFs with frequencies far below the dangerous radio frequency range [ 10 , 96 ] and orders of magnitude below the frequencies used in routine MRI [ 97 ].…”

Section: Mht Workflowmentioning

confidence: 99%

“…On the basis that MF strength could safely be increased given a compensatory decrease in the target region size (i.e., a smaller tumor), Hergt et al, in 2007, proposed the higher threshold of 5.00 × 10 9 Am −1 s −1 for a target region with a diameter less than the 30 cm tested by Brezovich [ 98 , 99 , 101 ]. Up to this point, no clinical studies on MHT in HGGs have surpassed this threshold; the maximum H × f used in two such trials was 1.50 × 10 9 Am −1 s [ 9 , 50 , 75 ]. Pulsed heating has been shown to minimize the non-specific eddy current heating [ 14 , 102 , 103 ].…”

Section: Mht Workflowmentioning

confidence: 99%

“…Magnetic hyperthermia therapy (MHT) is a re-emerging treatment approach for HGGs consisting of local heat generation in the tumor region through the direct delivery of magnetic nanoparticles (MNPs), which are activated by exposure to an external alternating magnetic field (AMF) [ 6 , 7 , 8 , 9 , 10 ]. The major advantages of MHT are its ability to focus heating on a small volume of a tumor without damaging surrounding tissue and its lack of ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

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Magnetic Hyperthermia Therapy for High-Grade Glioma: A State-of-the-Art Review

Rodriguez,

Rivera,

Zhang

et al. 2024

Pharmaceuticals

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Magnetic hyperthermia therapy (MHT) is a re-emerging treatment modality for brain tumors where magnetic nanoparticles (MNPs) are locally delivered to the brain and then activated with an external alternating magnetic field (AMF) to generate localized heat at a site of interest. Due to the recent advancements in technology and theory surrounding the intervention, clinical and pre-clinical trials have demonstrated that MHT may enhance the effectiveness of chemotherapy and radiation therapy (RT) for the treatment of brain tumors. The future clinical success of MHT relies heavily on designing MNPs optimized for both heating and imaging, developing reliable methods for the local delivery of MNPs, and designing AMF systems with integrated magnetic particle imaging (MPI) for use in humans. However, despite the progression of technological development, the clinical progress of MHT has been underwhelming. This review aims to summarize the current state-of-the-art of MHT and offers insight into the current barriers and potential solutions for moving MHT forward.

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Section: Discussionmentioning

confidence: 99%

Section: Mht Workflowmentioning

confidence: 99%

Section: Mht Workflowmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Magnetic Hyperthermia Therapy for High-Grade Glioma: A State-of-the-Art Review

Rodriguez,

Rivera,

Zhang

et al. 2024

Pharmaceuticals

Self Cite

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show abstract

“…In addition, the protective blood-brain barrier (BBB) also prevents most theranostic agents from entering into the tumor tissue. 3 Therefore, many strategies have been developed for precise diagnosis and treatment of GBM, including magnetic hyperthermia, 4,5 gene therapy, 6,7 high intensity focused ultrasound therapy, 8,9 immunotherapy 10,11 and gas therapy. 12,13 Recently, modulating the tumor metabolism has emerged as a promising therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%