Neurotensin and Hepatocellular Carcinoma

Hepatitis C virus NS5A-regulated gene expression and signaling revealed via microarray and comparative promoter analyses

“…Neurotensin is transiently expressed in the fetal liver, suppressed in the adult liver, and re-expressed in certain liver cancers. 21 We identified additional genes up-regulated by NS5A that were previously reported to be overexpressed in HCC, such as epidermal growth factor receptor, aldose reductase, and osteopontin. [22][23][24] Decorin expression suppressed in HCC 25 was down-regulated by NS5A.…”

Isolation and Characterization of an Huh.7.5.1-Derived Cell Clone Highly Permissive to Hepatitis C Virus

“…Girard et al previously showed that NTS is highly upregulated in HCV NS5A-expressing Huh7 cells (37) and may be associated with efficient HCV replication. The genes NTS and AFP are also known to be upregulated in hepatic tumors (38,39), and the protein SEC61G is required for tumor cell survival (40). In addition, AGR2 acts as a p53 tumor suppressor inhibitor (41).…”