Neurotensin in human small cell lung carcinoma

Goedert, Michel; Reeve, Julie G.; Emson, Piers C.; Bleehen, Norman M.

doi:10.1038/bjc.1984.160

Cited by 23 publications

(3 citation statements)

References 20 publications

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“…[1][2][3][4][5] Our previous findings 19 revealed a unique biophysical mechanism that has the potential to yield a more selective targeting approach for NTSR-1 mediated oncogenesis. We specifically demonstrated that NTS-stimulated NTSR-1 preferentially localizes within SMDs, to interact with Gα q/11 subunits.…”

Section: Discussionmentioning

confidence: 99%

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Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Heakal

Woll

Fox

et al. 2011

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 99%

“…The overexpression of the G-protein coupled neurotensin receptor, NTSR-1, and its endogenous ligand, NTS, plays a key role in the development and progression of several types of tumors including breast, 1 pancreas, 2 prostate, 3 colon 4 and lung 5 cancers. In invasive ductal breast carcinomas, NTS expression is regulated by estrogen.…”

Section: Introductionmentioning

confidence: 99%

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Heakal

Woll

Fox

et al. 2011

Cancer Biology & Therapy

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“…Neurotensin is produced by some SCLC (Wood et al, 1981;Goedert et al, 1984;Moody et al, 1985b into the circulation. Acting as an endocrine hormone, it stimulates hepatic glycogenolysis and has pressor effects on arteriolar smooth muscle, mediated by Ca2+-mobilising VI receptors.…”

Section: Neurotensinmentioning

confidence: 99%

Neuropeptide growth factors and cancer

Woll

1991

Br J Cancer

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Isolation and sequencing of a new biologically active peptide from human lung carcinoma

Hsi¹,

Wu²,

Chen³

et al. 1986

Biomedical Chromatography

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A biologically active peptide designated hLCP has been isolated and purified to homogeneity from human lung carcinoma by means of acidic extraction and successive chromatography on Sephadex G-50, Toyopearl HW-40 F and reverse-phase high performance liquid chromatography columns. Analysis showed that peptide consists of thirteen amino acids. Primary structure of hLCP has been deduced by double-coupling Edman degradation combined with enzyme digestion as H-Ser-Pro-Pro-Asp-Gly-Lys-Lys-Glx-Ser-Ala-Asp-Val-Lys-OH. hLCP possessed significant excitatory activity on an electrical stimulation induced contraction. No hLCP could be detected in normal lung tissue. The possibility of using hLCP as a biochemical marker in the clinic for the early detection of lung carcinoma is being investigated.

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Neurotensin in human small cell lung carcinoma

Cited by 23 publications

References 20 publications

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains

Neuropeptide growth factors and cancer

Isolation and sequencing of a new biologically active peptide from human lung carcinoma

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