Neurotensin protects pancreatic beta cells from apoptosis

Coppola, Thierry; Béraud-Dufour, Sophie; A, Antoine; Vincent, Jean‐Pierre; Mazella, Jean

doi:10.1016/j.biocel.2008.03.015

Cited by 36 publications

(30 citation statements)

References 25 publications

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“…Neurotensin can stimulate COX-2 and PGE2 release from HT-29 cells, suggesting a mechanism for its restorative effects on mucosal epithelium. Beraud-Dufour et al [63] recently published a follow-up to an earlier study documenting the antiapoptotic effects of neurotensin on pancreatic beta cells by way of PI3K activation [64]. In the current study, they demonstrated a cell-surface interaction between NTS2 and NTS3 that is required for the antiapoptotic effects of neurotensin.…”

Section: Neurotensin and Gastrointestinal Physiologymentioning

confidence: 59%

The role of neurotensin in physiologic and pathologic processes

Mustain

Rychahou

Evers

2011

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

117

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The review highlights the wide array of biological processes in which neurotensin has a role, and summarizes the most recent advances in various fields of neurotensin research. The knowledge gained through this research has led to the development of first-in-class drugs for the treatment of various medical conditions, and it is clear that in the coming years some of these agents will be ready to move from the bench to the bedside in clinical trials.

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Section: Neurotensin and Gastrointestinal Physiologymentioning

confidence: 59%

The role of neurotensin in physiologic and pathologic processes

Mustain

Rychahou

Evers

2011

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

117

View full text Add to dashboard Cite

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“…It was found in the most differentiated malignant cell lines and patient's primary cells, whereas NTSR1 was prominently expressed in undifferentiated neoplastic cells (11). The antiapoptotic effect of neurotensin on pancreatic cell line depends on its binding to NTSR2 (53). Therefore, we could hypothesize that NTSR2 overexpression in CLL could be related to the apoptosis defect of these cells (58).…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of Neurotensin and Specific Receptors, NTSR1 and NTSR2, in Normal and Malignant Human B Lymphocytes

Saada

Marget

Fauchais

et al. 2012

The Journal of Immunology

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Neurotensin, a neuropeptide growth factor, and its two specific neurotensin receptors, NTSR1 and NTSR2, were shown to be expressed by human B cell lines. Another NTSR, sortilin, which is common to neurotensin and neurotrophins, was also detected as we have previously described. Neurotensin was functional in B cell lines; it induced their proliferation and inhibited apoptosis induced by serum deprivation or Fas activation. Quantitative study of gene expression in two malignant B cell diseases showed that NTSR2 was overexpressed, NTSR1 decreased, and neurotensin was unexpressed in B cell leukemia patient’s cells, as compared with healthy B cells. However, these expressions did not significantly change in large diffuse B cell lymphoma lymph nodes compared with benign ones. This study points out that neurotensin and its two specific receptors are expressed in human B lymphocytes. Such expressions were not described, and their relationship in B cell diseases, especially in chronic B cell leukemia, needs to be considered further in regard to these findings.

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“…Indeed, at low glucose concentration, NT stimulates insulin release, whereas at high glucose level, NT decreases the glucose-induced insulin secretion [14]. Recently, NT was shown to be involved in the protection of both pancreatic beta cells and of islets from cytotoxic agents, like Il-1β and staurosporine [13]. This protective effect is characterized by a strong decrease (40%) of Il-1β and staurosporine-induced caspase-3 activity.…”

Section: Anti-apoptotic Effects Of Nt In Non-neuronal Cell Typesmentioning

confidence: 99%

“…NT is also involved in the protection of pancreatic beta cells against cytotoxic molecules [13] and in the regulation of insulin secretion [14,15]. …”

Section: Introductionmentioning

confidence: 99%

The Anti-Apoptotic Role of Neurotensin

Devader

Béraud-Dufour

Coppola

et al. 2013

Cells

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The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the periphery. This review summarizes studies that clearly evidenced the protective effect of neurotensin through its three known receptors. The pivotal involvement of the neurotensin receptor-3, also called sortilin, in the molecular mechanisms of the anti-apoptotic action of neurotensin has been analyzed in neuronal cell death, in cancer cell growth and in pancreatic beta cell protection. The relationships between the anti-apoptotic role of neurotensin and important physiological and pathological contexts are discussed in this review.

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Neurotensin protects pancreatic beta cells from apoptosis

Cited by 36 publications

References 25 publications

The role of neurotensin in physiologic and pathologic processes

The role of neurotensin in physiologic and pathologic processes

Differential Expression of Neurotensin and Specific Receptors, NTSR1 and NTSR2, in Normal and Malignant Human B Lymphocytes

The Anti-Apoptotic Role of Neurotensin

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