Neurotensin stimulates pancreatic exocrine secretion in rats

Khalil, Talaat; Fujimura, Masaki; Greeley, George H.; Townsend, Courtney M.; Thompson, James C.

doi:10.1016/0167-0115(86)90069-8

Cited by 15 publications

(7 citation statements)

References 12 publications

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“…[223][224][225] Intestinal administration of fatty acids increased plasma neurotensin levels and the pattern of neurotensin-stimulated pancreatic secretion is similar to that stimulated by intestinal fat. It has been demonstrated in several species including humans that neurotensin stimulates pancreatic secretion.…”

Section: Neurotensinmentioning

confidence: 81%

Regulation of Pancreatic Secretion

Liddle¹

2012

Physiology of the Gastrointestinal Tract

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Section: Neurotensinmentioning

confidence: 81%

Regulation of Pancreatic Secretion

Liddle¹

2012

Physiology of the Gastrointestinal Tract

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“…1983], Neurotensin has been reported to have a stimulatory effect on pancreatic exocrine secretion [Baca et al. 1982: Khalil et al. 1986] and infusion of neurotensin into young rats induces hyperplasia in the pancreas [Feurle et al.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Study of the Developing Endocrine Pancreas of the Opossum (<i>Didelphis virginiana</i>)

Krause

Cutts²,

Yamada³

1989

Cells Tissues Organs

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Cells immunoreactive for insulin, glucagon, somatostatin, bovine pancreatic polypeptide and 5-hydroxytryptamine are found in the pancreas of the newborn opossum and of all later stages examined. All immunoreactive cell types are present in primary and secondary islets and within elements of the exocrine pancreas. Cells immunoreactive for glucagon, bovine pancreatic polypeptide, somatostatin and 5-hydroxytryptamine generally are confined to the periphery of secondary (intralobular) islets, whereas insulin-immunoreactive cells occupy the central region. Endocrine cells within primary (interlobular) islets are randomly scattered. A small number of pancreatic-polypeptide-immunoreactive cells are reactive for the amine 5-hydroxytryptamine also, but the reverse is not observed.The endocrine pancreas continues to differentiate and develop throughout postnatal life and into adulthood. Little difference was observed between the head and tail regions of the opossum pancreas for the measurements made.

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“…Ingestion of fat is the strongest stimulus for NT release in animals and humans (15,16,19,27,43,47,49), and circulating NT stimulates pancreatic secretion (7,18,34), slows intestinal transit (29), and promotes intestinal absorption of fatty acid (5). However, the possible effects of NT on BA cycling have not received much attention, except for the stimulatory action of NT on gallbladder contraction in some species (20,26,56).…”

mentioning

confidence: 99%

Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats

Gui¹,

Dobner

Carraway³

2001

American Journal of Physiology-Gastrointestinal and Liver Physi

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away. Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats. Am J Physiol Gastrointest Liver Physiol 281: G1413-G1422, 2001.-Initial studies on the digestive hormone neurotensin (NT) showing that intestinal NT mRNA expression and blood levels were altered in rats fed chow containing bile acid (BA) and the BA chelator cholestyramine led us to investigate the role of NT in the enterohepatic circulation of BA. In fasted, anesthetized rats with common bile ducts cannulated for bile collection, intravenous NT infusion (10 pmol ⅐ kg Ϫ1 ⅐ min Ϫ1 ) enhanced BA output relative to control over 3 h in animals administered donor bile into the duodenum (30 l/min). This suggested that the effect of NT was on the return of BA from the intestine to the liver, which is rate determining in the normal process. In rats prepared as described above and administered

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Neurotensin stimulates pancreatic exocrine secretion in rats

Cited by 15 publications

References 12 publications

Regulation of Pancreatic Secretion

Regulation of Pancreatic Secretion

Immunohistochemical Study of the Developing Endocrine Pancreas of the Opossum (<i>Didelphis virginiana</i>)

Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats

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