Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine

Abstract

The ameliorative effect of L-arginine (LA) and L-carnitine (LC) against fipronil (FPN)-induced neurotoxicity was explored. In this case, 36 adult male rats were randomly divided into six groups: group I received distilled water, group II received 500 mg/kg LA, group III received 100 mg/kg LC, group IV received 4.85 mg/kg FPN, group V received 4.85 mg/kg FPN and 500 mg/kg LA and group VI received 4.85 mg/kg FPN and 100 mg/kg LC for 6 weeks. Cognitive performance was assessed using Barnes maze (BM). Serum corticosterone, brain total antioxidant capacity (TAC), malondialdehyde (MDA) and dopamine were measured. Histopathology and immunohistochemistry of ionized calcium-binding adaptor (Iba-1), doublecortin (DCX) and serotonin (S-2A) receptors were performed. Fipronil induced noticeable deterioration in spatial learning and memory performance. In addition, FPN significantly (p < 0.05) diminished brain antioxidant defense system and dopamine coincide with elevated serum corticosterone level. Histopathological examination revealed degenerative and necrotic changes. Furthermore, Iba-1 and DCX were significantly expressed in cortex and hippocampus whereas S-2A receptors were significantly lowered in FPN group. However, administration of LA or LC alleviated FPN-induced deteriorations. In conclusion, LA and LC could be prospective candidates for mitigation of FPN-induced neurotoxicity via their antioxidant, anti-inflammatory and neuropotentiating effects.

Neuroprotective Effect of White Nelumbo nucifera Gaertn. Petal Tea in Rats Poisoned with Mancozeb

“…Our study agreed with a prior study where mancozeb induced hypercorticosteronaemia in mice after ingestion by lactating mothers for 28 days [30], and is similar to a study in which fipronil pesticide-induced elevated serum corticosterone in adult male rats due to disruption of the hypothalamus-pituitary-adrenal (HPA) axis [58]. Elevated cortisol levels were also observed in Garra gotyla fish after exposure to manganese for a week [59].…”

Correction: Mahmoud et al. Neurotoxic Effect of Fipronil in Male Wistar Rats: Ameliorative Effect of L-Arginine and L-Carnitine. Biology 2021, 10, 682

“…In the original publication [1], there was a missing part in the legend for Figure 5. The correct legend appears below.…”

“…The correct legend appears below. In the original publication [1], there was a mistake in Figures 4 and 6 as published. Figure 4e was misdragged, and the dentate gyrus of the fipronil +L-carnitine group was misdragged in Figure 6…”

Histopathological and Behavioral Impairments in Zebrafish (Danio rerio) Chronically Exposed to a Cocktail of Fipronil and Pyriproxyfen

“…Chronic treatment of male Wistar rats (6 weeks) with 4.85 mg kg −1 FIP showed impairments in spatial learning and memory performance assessed by Barnes maze. In addition, decreases in antioxidant system activity and dopamine and elevated levels in malondialdehyde (MDA) and serum corticosterone were obtained [18]. Several of these Due to its massive use and negative impact on bee populations, FIP has been restricted in several countries.…”