Neurotoxic effect of linamarin in rats associated with cassava (Manihot esculenta Crantz) consumption

Rivadeneyra-Domínguez, Eduardo; Vázquez-Luna, Alma; Rodríguez‐Landa, Juan Francisco; Díaz-Sobac, R.

doi:10.1016/j.fct.2013.06.004

Cited by 32 publications

(24 citation statements)

References 19 publications

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“…De ser el caso, la rata no reconocería las condiciones de la caja de prueba y la exploraría como si fuera un ambiente novedoso o desconocido. Cabe señalar que el incremento de la actividad locomotora en sesiones repetidas en la prueba de locomoción también ha sido identificado en ratas microinyectadas en el hipocampo dorsal con neurotóxicos derivados de las cícadas o con la administración oral del jugo de yuca que contiene linamarina [15][16][17]27 . Estas observaciones en la rata podrían coincidir con los reportes clínicos en pacientes que han desarrollado enfermedades neurológicas asociadas al consumo inadecuado de yuca, que, además de presentar alteraciones motoras, también desarrollan deterioro del aprendizaje y la memoria 3,28 .…”

Section: Discussionunclassified

Alteraciones motoras inducidas por la microinyección de linamarina en el hipocampo dorsal de la rata Wistar

Rivadeneyra-Domínguez

Rodríguez‐Landa

2016

Neurología

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Section: Discussionunclassified

Alteraciones motoras inducidas por la microinyección de linamarina en el hipocampo dorsal de la rata Wistar

Rivadeneyra-Domínguez

Rodríguez‐Landa

2016

Neurología

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“…Preparation cassava juice was performed according to procedures described in previous studies (Rivadeneyra-Domínguez et al, 2013). To avoid any degradation process, the cassava juice was freshly prepared every day before administration.…”

Section: Methodsmentioning

confidence: 99%

“…None of the animals drowned. After this initial swimming behavior, the rats displayed lateral swimming as previously was described (Rivadeneyra-Domínguez et al, 2013). The dependent variable was the number of times that lateral swimming was displayed by the rat in this test.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, has been reported significant damage in brain structures involved in motor and cognitive integration including thalamic nuclei, piriform cortex, ventral nuclei, paraventricular area, and hippocampus, among others. In a previous study, Rivadeneyra-Domínguez et al (2013) was reported that treated rats with cassava juice, in which linamarin was identified, shown alterations in motor incoordination (i.e., an increase in the lateral swimming) when they were evaluated to the swim test; which evidenced the neurotoxic effects associated probably with linamarin contained in the cassava juice.…”

Section: Introductionmentioning

confidence: 93%

“…The potato and cassava are the most important edible tubers because of its high carbohydrate content. Cassava root is usually consumed fresh, or processed as flour, some populations of Africa and America also consume leaves due to its medicinal properties (FAO and WHO, 2009; Rivadeneyra-Domínguez et al, 2013). However, cassava contains cyanogenic glycosides (linamarin and lotaustralin) which through hydrolysis produce cyanohydrin and glucose, and it is metabolized into acetone and hydrocyanic acid free.…”

Section: Introductionmentioning

confidence: 99%

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A standardized extract of Ginkgo biloba prevents locomotion impairment induced by cassava juice in Wistar rats

Rivadeneyra-Domínguez

Vázquez-Luna

Rodríguez‐Landa

et al. 2014

Front. Pharmacol.

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The long-term consumption of cassava (Manihot esculenta Crantz) juice produce neurotoxic effects in the rat, characterized by an increased motor activity in the open field test and presence of uncoordinated swim (i.e., lateral swimming), in the swim test; which has been associated with damage in the hippocampus (CA1). On the other hand, flavonoids content in the Ginkgo biloba extract has been reported to produces neuroprotective effects at experimental level; therefore we hypothesized that G. biloba extract may prevents the motor alterations produced by cassava juice and reduce cellular damage in hippocampal neurons of the rat. In present study the effect of vehicle, cassava juice (linamarin, 0.30 mg/kg), G. biloba extract (dry extract, 160 mg/kg), and combination of treatment were evaluated in the open field and swim tests to identify locomotor and hippocampal alterations in adult male Wistar rats. All treatments were administered once per day, every 24 h, for 28 days, by oral rout. The effect was evaluated at 0, 7, 14, 21, and 28 days of treatment. The results show that cassava group from day 14 of treatment increase crossing and rearing in the open field test, as compared with the vehicle group; while in the swim test produces an uncoordinated swim characterized by the lateral swim. In this same group an increase in the number of damage neurons in the hippocampus (CA1) was identified. Interestingly, both behavioral and neuronal alterations produced by cassava juice administration were prevented by treatment with G. biloba extract. The results shown that G. biloba extract exert a protective effect against behavioral and neuronal damage associated with consumption of cassava juice in the rat. These effects are possibly related with flavonoid content in the G. biloba extract.

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Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

Omidkhoda

Razavi

Hosseinzadeh

2019

Phytotherapy Research

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Nowadays in our developing and industrial world, humans' health or even their life is threatened by exposure to poisons. In this situation, detecting a protective compound could be helpful and interesting. In the present article, we collected and reviewed all studies, which have been conducted so far about the protective effects of Ginkgo biloba L. (GB), one of the most ancient medicinal tree species, against toxicities induced by chemical toxic agents, natural toxins, and also radiation. In overall, investigations showed that GB exerts the antioxidant, antiinflammatory, antiapoptotic, and antigenotoxicity effects in different toxicities. There are also some special mechanisms about its protective effects against some specific toxic agents, such as acetylcholine esterase inhibition in the aluminium neurotoxicity or membrane‐bond phosphodiesterase activation in the triethyltin toxicity. Ginkgolide A was the most investigated active ingredient of G. biloba leaf extract as a protective compound against toxicities, which had the similar effects of total extract. A few clinical studies have been conducted in this field, which demonstrated the beneficial effects of GB against toxic agents. However, the promising effects of this valuable herbal extract will practically remain useless without carrying out more clinical studies and proving its effects on human beings.

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Neurotoxic effect of linamarin in rats associated with cassava (Manihot esculenta Crantz) consumption

Cited by 32 publications

References 19 publications

Alteraciones motoras inducidas por la microinyección de linamarina en el hipocampo dorsal de la rata Wistar

Alteraciones motoras inducidas por la microinyección de linamarina en el hipocampo dorsal de la rata Wistar

A standardized extract of Ginkgo biloba prevents locomotion impairment induced by cassava juice in Wistar rats

Protective effects ofGinkgo bilobaL. against natural toxins, chemical toxicities, and radiation: A comprehensive review

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