Neurotoxic responses in brain tissues of rainbow trout exposed to imidacloprid pesticide: Assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and acetylcholinesterase activity

Topal, Ahmet; Alak, Gonca; Özkaraca, Mustafa; Yeltekin, Aslı Çilingir; Çomaklı, Selim; Açıl, Gürdal; Köktürk, Mine; Atamanalp, Muhammed

doi:10.1016/j.chemosphere.2017.02.047

Cited by 149 publications

(65 citation statements)

References 53 publications

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“…As for AchE activity, this enzyme is extensively used as a biomarker of xenobiotic exposure, particularly those that are neurotoxic (such as metals [22] and organophosphate pesticides), and changes in its activity can lead to alterations in behavior and neuromuscular activity [42]. AchE is a common target for many chemical compounds and, thus, the exposure to xenobiotics is frequently associated with AchE activity inhibition [86,87]. Nevertheless, an activation of this enzyme may also occur, although less commonly, as a result of (i) brain cell apoptosis (e.g., References [80,88,89]), (ii) enhanced synthesis of AchE splicing variants (e.g., AChE-R) due to stress [90], or (iii) xenobiotics' modulation of the fish cholinergic system [89,91,92].…”

Section: Interactive Effects Of Hg and Climate Change-related Stressomentioning

confidence: 99%

Mercury in Juvenile Solea senegalensis: Linking Bioaccumulation, Seafood Safety, and Neuro-Oxidative Responses under Climate Change-Related Stressors

et al. 2020

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Mercury (Hg) is globally recognized as a persistent chemical contaminant that accumulates in marine biota, thus constituting an ecological hazard, as well as a health risk to seafood consumers. Climate change-related stressors may influence the bioaccumulation, detoxification, and toxicity of chemical contaminants, such as Hg. Yet, the potential interactions between environmental stressors and contaminants, as well as their impacts on marine organisms and seafood safety, are still unclear. Hence, the aim of this work was to assess the bioaccumulation of Hg and neuro-oxidative responses on the commercial flat fish species Solea senegalensis (muscle, liver, and brain) co-exposed to dietary Hg in its most toxic form (i.e., MeHg), seawater warming (ΔT°C = +4 °C), and acidification (pCO2 = +1000 µatm, equivalent to ΔpH = −0.4 units). In general, fish liver exhibited the highest Hg concentration, followed by brain and muscle. Warming enhanced Hg bioaccumulation, whereas acidification decreased this element’s levels. Neuro-oxidative responses to stressors were affected by both climate change-related stressors and Hg dietary exposure. Hazard quotient (HQ) estimations evidenced that human exposure to Hg through the consumption of fish species may be aggravated in tomorrow’s ocean, thus raising concerns from the seafood safety perspective.

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Section: Interactive Effects Of Hg and Climate Change-related Stressomentioning

confidence: 99%

Mercury in Juvenile Solea senegalensis: Linking Bioaccumulation, Seafood Safety, and Neuro-Oxidative Responses under Climate Change-Related Stressors

et al. 2020

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“…This result may be because the exposure time was not long enough, the content of 8-OHdG content was too late to return to the control level, or it may be due to the toxicity of sulfoxaflor to earthworms, which caused irreversible damage to the DNA of earthworm. Topal et al [45] found similar results by researching the effect of imidacloprid on the 8-OHdG content in rainbow trout. These findings indicated that 8-OHdG can be used as a sensitive biomarker for DNA damage, and the increased 8-OHdG content indicates that the sulfoxaflor may have caused genotoxicity to earthworms.…”

Section: Oxidative Damage Effects In Earthworms Induced By Sulfoxaflormentioning

confidence: 58%

“…8-OHdG is one of the important indicators reflecting DNA oxidative damage, and a large number of studies indicate that 8-OHdG can be used as a biomarker for DNA oxidative damage by endogenous and exogenous factors [43][44][45]. As shown in Figure 5B, from day 7 to day 28, the content of 8-OHdG showed an upward trend.…”

Section: Oxidative Damage Effects In Earthworms Induced By Sulfoxaflormentioning

confidence: 94%

The Toxic Effects of Sulfoxaflor Induced in Earthworms (Eisenia fetida) under Effective Concentrations

Zhang

Wang

Liu

et al. 2020

IJERPH

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Sulfoxaflor is a new kind of neonicotinoid insecticide that is used to control sap-feeding insect pests. In this study, a hazard assessment of sulfoxaflor on soil invertebrate earthworms was performed under effective concentrations. The results showed that different exposure times and doses had significant influence on the toxicity of sulfoxaflor. Sulfoxaflor degraded quickly in artificial soil with a degradation rate of 0.002–0.017 mg/(kg·d) and a half-life of 12.0–15.4 d. At 0.5 mg/kg and 1.0 mg/kg, the ·OH− content, antioxidant enzyme activeities, thiobarbituric acid reactive substances (TBARS) content and 8-OHdG content had significant differences compared to those in the control group. On the 56th day, significant differences were only observed in the Glutathione S-transferase enzyme (GST) activity and 8-OHdG content at 1.0 mg/kg compared to those in the control group due to the degradation of sulfoxaflor. This indicated that the risk of sulfoxaflor to earthworms was reduced because it was easily degraded in soil. However, because sulfoxaflor is a super toxic pollutant to earthworms, high concentrations of sulfoxaflor should not be released into the soil environment.

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“…AChE is a good candidate that is responsible for the hydrolysis of the neurotransmitter acetylcholine, which plays an important role in the nervous system [43]. AChE could be a target for pollutants, resulting in the inhibition of its activity, failure of synaptic transmission, and muscle overstimulation [44,45]. Thus, AChE activity has been used as a biomarker to evaluate the neurotoxicity of pollutants.…”

Section: Discussionmentioning

confidence: 99%

Ecotoxicological Effect of Single and Combined Exposure of Carbamazepine and Cadmium on Female Danio rerio: A Multibiomarker Study

Shi

Liu

et al. 2019

Applied Sciences

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In aquatic environments, organisms are exposed to mixtures of pollutants which may change the toxicity profile of each contaminant, compared to its toxicity alone. Carbamazepine (CBZ) and cadmium (Cd) are among the pollutants that co-occur in aquatic environments. To date, most research about their toxicity towards aquatic vertebrates is based on single exposure experiments. The present study aims to evaluate single and combined effects of CBZ and Cd on biomarkers in female Danio rerio (zebrafish) by exposing them to environmentally relevant concentrations of these two pollutants for ten days. Four kinds of biomarkers involved in antioxidant systems, energy metabolism, nervous system, and endocrine disruption, respectively, were studied. Our research results coincided with those of former studies in single exposure experiments. However, the combined exposure of CBZ and Cd exerted different responses from other studies in which these two contaminants were examined alone in zebrafish. The present study evidenced the need to conduct more coexposure studies to enhance the environmental relevance of these experimental results.

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Neurotoxic responses in brain tissues of rainbow trout exposed to imidacloprid pesticide: Assessment of 8-hydroxy-2-deoxyguanosine activity, oxidative stress and acetylcholinesterase activity

Cited by 149 publications

References 53 publications

Mercury in Juvenile Solea senegalensis: Linking Bioaccumulation, Seafood Safety, and Neuro-Oxidative Responses under Climate Change-Related Stressors

Mercury in Juvenile Solea senegalensis: Linking Bioaccumulation, Seafood Safety, and Neuro-Oxidative Responses under Climate Change-Related Stressors

The Toxic Effects of Sulfoxaflor Induced in Earthworms (Eisenia fetida) under Effective Concentrations

Ecotoxicological Effect of Single and Combined Exposure of Carbamazepine and Cadmium on Female Danio rerio: A Multibiomarker Study

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