Neurotoxicity

Abou‐Donia, Mohamed B.

doi:10.1002/9781118683484.ch18

Cited by 3 publications

(3 citation statements)

References 71 publications

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“…Ataxia, tremor, tachycardia, muscle fasciculation, and seizures were observed after administration of nicotine, in less than 5% rats twice or thrice out of the total 12-week treatment, which may be due to the initial phase of the nicotinic cholinergic stimulation as it is a parasympathomimetic alkaloid. 34 However, these signs and symptoms were disappeared within 2-3 min and no death was reported throughout the study period. Previous studies found that explorative behavior in the rodents summarizes a broad spectrum of behavioral patterns such as, risk assessment behaviors, walking, rearing, climbing, sniffing and manipulating objects, which is gradually inhibited by anxiety; thereby representing an indirect measurement of anxiety.…”

Section: Discussionmentioning

confidence: 83%

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#

Naha

Gandhi²,

et al. 2017

Hum Exp Toxicol

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Section: Discussionmentioning

confidence: 83%

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#

Naha

Gandhi²,

et al. 2017

Hum Exp Toxicol

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“…All of our findings indicated that the LAAO had no impact on the animals and had negligible effects when compared to the control group. According to Abdelkafi-Koubaa this indicates that when experimental animals are injected with 2.5g/mL, there are no negative side effects (Abdelkafi-Koubaa et al,2021), unlike paclitaxel, which has many serious side effects (Abou-Donia et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Effect of Cerastes cerastes LAAO on Some Hematological Parameters in Hepatocellular Carcinoma-Induced in Rats

Mahmoud

Saber

Loutfy

et al. 2023

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Background: One of the most prevalent cancers globally is hepatocellular carcinoma, which is also the most prevalent kind of primary liver cancer in Egypt. Diethyl nitrosamine (DEN) is a well-known, highly carcinogenic substance for the liver. It is well known that DENA damages DNA repair enzymes and is typically utilized to cause liver cancer in rats used as experimental animals.Objective: To assess the hematological parameters in hepatocellular carcinoma induced in rats treated with paclitaxel and l-amino acid oxidase (LAAO) (PAC).Materials and methods: 25 adult, mature, healthy male albino rats (Rattus rattus) with an average weight of (100 ± 10 g) were used in this investigation. The rats were divided into 5 groups, each with 5 rats. At the conclusion of the experiment, hematological parameters were examined for all groups.Results: When treated with LAAO and PAC, the results demonstrated that all hematological parameters significantly changed from their respective levels in the control group. As compared to the DENA(HCC) group, the results revealed improvements for several criteria. Conclusion: WBCs, RBCs, Hb, and PLTs were all enhanced by the administration of LAAO and PAC. etc.

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“…Ecotoxicology is a relatively young discipline, which has partly inherited its methodological focus from (mammalian) toxicology, at least for research with an applied scope (Newman & Clements, 2008). Mammalian toxicology has a strong focus on extrapolating chemical effects from a few selected species (e.g., rat, mouse) to humans (Abou‐Donia, 2015), whereas a major part of ecotoxicological research aims to quantify the responses of a few selected species to (typically single) chemicals under controlled laboratory conditions, as a basis to evaluate the potential implications of chemicals in ecosystems (Cairns, 1986; Schäfer, 2014). Standardized experimental test systems with single, laboratory‐adapted species and chemicals still form the backbone of current chemical regulatory risk assessment (Dale et al, 2008).…”

Section: The General Approach Of Ecotoxicology and (Applied) Ecologymentioning

confidence: 99%

Chemical Mixtures and Multiple Stressors: Same but Different?

Schäfer

Jackson

Juvigny‐Khenafou

et al. 2023

Enviro Toxic and Chemistry

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Ecosystems are strongly influenced by multiple anthropogenic stressors, including a wide range of chemicals and their mixtures. Studies on the effects of multiple stressors have largely focussed on nonchemical stressors, whereas studies on chemical mixtures have largely ignored other stressors. However, both research areas face similar challenges and require similar tools and methods to predict the joint effects of chemicals or nonchemical stressors, and frameworks to integrate multiple chemical and nonchemical stressors are missing. We provide an overview of the research paradigms, tools, and methods commonly used in multiple stressor and chemical mixture research and discuss potential domains of cross‐fertilization and joint challenges. First, we compare the general paradigms of ecotoxicology and (applied) ecology to explain the historical divide. Subsequently, we compare methods and approaches for the identification of interactions, stressor characterization, and designing experiments. We suggest that both multiple stressor and chemical mixture research are too focused on interactions and would benefit from integration regarding null model selection. Stressor characterization is typically more costly for chemical mixtures. While for chemical mixtures comprehensive classification systems at suborganismal level have been developed, recent classification systems for multiple stressors account for environmental context. Both research areas suffer from rather simplified experimental designs that focus on only a limited number of stressors, chemicals, and treatments. We discuss concepts that can guide more realistic designs capturing spatiotemporal stressor dynamics. We suggest that process‐based and data‐driven models are particularly promising to tackle the challenge of prediction of effects of chemical mixtures and nonchemical stressors on (meta‐)communities and (meta‐)food webs. We propose a framework to integrate the assessment of effects for multiple stressors and chemical mixtures. Environ Toxicol Chem 2023;00:1–22. © 2023 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Neurotoxicity

Cited by 3 publications

References 71 publications

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#

Effect of Cerastes cerastes LAAO on Some Hematological Parameters in Hepatocellular Carcinoma-Induced in Rats

Chemical Mixtures and Multiple Stressors: Same but Different?

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Neurotoxicity

Cited by 3 publications

References 71 publications

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex#

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex#

Effect of Cerastes cerastes LAAO on Some Hematological Parameters in Hepatocellular Carcinoma-Induced in Rats

Chemical Mixtures and Multiple Stressors: Same but Different?

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Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#

Nicotine and cigarette smoke modulate Nrf2-BDNF-dopaminergic signal and neurobehavioral disorders in adult rat cerebral cortex^#