Neurotoxicity and oxidative stress induced by permethrin in gills of the freshwater mussel<i>Unio ravoisieri</i>

Khazri, Abdelhafidh; Sellami, Badreddine; Hanachi, Amel; Dellali, Mohamed; Eljarrat, Ethel; Beyrem, Hamouda; Mahmoudi, Ebrahim

doi:10.1080/02757540.2016.1248948

Cited by 22 publications

(6 citation statements)

References 70 publications

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“…Regarding MDA, an increase in MDA levels in gill tissues of mussels U. pictorum was observed especially at the last two concentrations of the pesticide with highest statistically significant (P0.05) value recorded in 2 mg/L (Fig 2 E). These findings with regard to the MDA levels are compatible with other study results (Khazri et al, 2017), who discovered that MDA increased in gill cells treated with high concentration cypermethrin (CYP) in freshwater mussels (Unio elongatulus eucirrus). The explanation of increasing in MDA may suggest that CYP may penetrate in to the cellular lipid membrane that may disturb the phospholipid orientation and may cause changes in membrane fluidity.…”

Section: Biomarkers Of Oxidative Stresssupporting

confidence: 92%

“…in agreement to our study, similar results were observed for other mussel species when the activity of glutathione was decreased significantly in digestive glands and gills after cypermethrin exposure (Pandey et al, 2016). However, significant decrease in GSH levels was observed only at high concentration of permethrin (Khazri et al, 2017). Also Köprücü et al, (2010) reported that the reduced GSH is the main non protein thiol and one of the key reductants found in cells.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 98%

“…The trend of CAT activity is in accordance with previous studies in which some pesticides caused increase in CAT activity. This elevation of CAT activity in gills helps in detoxification of the pesticide (Khazri et al, 2017). CAT is known to be of particular importance when the clearance of H 2 O 2 in high concentrations is required.…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

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Histopathological and Biochemical Biomarker Response of Mussel, Unio Pictorum, to Carbamate Pesticide Carbaryl: A Laboratory Study

Khudhur

Shekha

2019

IJAR

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An experiment was conducted to assess the effect of different concentrations of the insecticide carbaryl on histological and biochemical parameters including (SOD, GSH, rGSH, CAT and MDA) on gills tissue of freshwater mussel Unio pictorum for 96 hours. Significant increase in SOD and rGSH activities was observed in a concentration- dependent manner. However, statistically significant decrease in GSH levels was observed only at highest concentration. MDA levels reached higher rate at high concentration of carbaryl treated group. Mussels show behavioral responses during exposure by exhibiting increase in duration for shell closure and increase in mucus secretion. The histopathology of gills indicated that higher doses of carbaryl resulted in massive destruction in normal architecture of gill tissue. Molluscs accumulate contaminants in their body tissues and thus are used as bio-indicator for evaluating water quality and habitat degradation.

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Section: Biomarkers Of Oxidative Stresssupporting

confidence: 92%

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 98%

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

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Histopathological and Biochemical Biomarker Response of Mussel, Unio Pictorum, to Carbamate Pesticide Carbaryl: A Laboratory Study

Khudhur

Shekha

2019

IJAR

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“…The exposure design was selected based on previous published studies (Khazri et al, 2016;Sellami et al, 2017). The laboratory temperature was maintained at 19 °C (field temperature) and the water temperature was maintained at 17 °C, and pH was 8.7 (Khazri et al, 2017). Measurements were conducted by means of a temperature/conductivity meter (WTW LF 196,Weilheim,Germany), and pH meter (WTW, model pH 330/SET-1).…”

Section: Acclimation In the Laboratorymentioning

confidence: 99%

Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools

et al. 2022

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The cockle Cerastoderma edule was exposed to four concentrations (5, 10, 20 and 70 μg L-1) of carbamazepine (CBZ). This anticonvulsant was found to alter the mussel behavior of by reducing its clearance rate (CR). Analysis of CBZ accumulation in tissues of C. edule was carried out using HPLC-UV after 48 or 96 hours of exposure. In addition, an overproduction of H2O2 by the bivalves was detected following exposure to CBZ but nitrite levels remained unchanged. Moreover, superoxide dismutase and catalase activities showed a significant increase in relation to their contact with CBZ. The activity of the biotransformation enzyme gluthatione-S-transferase did not change during exposure. Malondialdehyde (MDA) levels indicating cellular damage, increased when bivalves were exposed to 20 and 70 μg l-1 of carbamazepine for 96 h CBZ. The results also indicate that acetylcholinesterase activity (AChE) was inhibited in all CBZ concentrations during the 48 h exposure period. However, during the 96 h exposure period, AChE was only inhibited at the highest concentration. Further studies are needed now for more exploration of the toxicity of CBZ since it could be bioaccumulable throughout the food web and may affect non-target organisms.

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“…Glutathione S-transferase (GST) and glutathione reductase (GR) are enzymatic biochemical markers which are widely used in the evaluation of oxidative stress [10,11]. Reduced glutathione (GSH) is non-enzymatic antioxidant that protects organisms against oxidative stress [12]. Malondialdehyde (MDA), a product of lipid peroxidation, is often used as an indicator of oxidative stress [13].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Some Biochemical Responses of Freshwater Mussels in Acute Imidacloprid Exposure

Yoloğlu¹

2019

Adıyaman University Journal of Science

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Imidacloprid is a widely used systemic neonicotinoid insecticide. The aim of this study is to identify potential harmful effects of imidacloprid in freshwater mussels (Unio mancus) which were exposed to sub-lethal concentrations (1, 10, 100, and 1000 µg AI L-1) for 96 h. For this aim, glutathione s-transferase (GST) activity, carboxylesterase (CaE) activity, acetylcholinesterase (AChE) activity, glutathione reductase (GR) activity, reduced glutathione (GSH) level, and malondialdehyde (MDA) level were evaluated as biochemical markers of exposure in the gills and digestive glands. The actual imidacloprid concentrations in the test waters were determined by LC-MS/MS analysis. The results showed that the AChE, GR, and CaE activities in the digestive glands significantly decreased at different exposure concentrations, while the MDA level significantly increased at the highest exposure concentration (p<0.05). Considering the results in the gills, the lowest exposure concentration caused inhibition in AChE activity, while the highest exposure concentration caused significant induction in GST activity, GSH level and MDA level (p<0.05). In addition, the measured imidacloprid concentrations were determined to be about 80% of the nominal imidacloprid concentrations. The data obtained from this study indicated that acute imidacloprid exposure caused biochemical alterations related to oxidative stress in mussels.

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Neurotoxicity and oxidative stress induced by permethrin in gills of the freshwater musselUnio ravoisieri

Cited by 22 publications

References 70 publications

Histopathological and Biochemical Biomarker Response of Mussel, Unio Pictorum, to Carbamate Pesticide Carbaryl: A Laboratory Study

Histopathological and Biochemical Biomarker Response of Mussel, Unio Pictorum, to Carbamate Pesticide Carbaryl: A Laboratory Study

Assessment of carbamazepine acute toxicity in the cockle Cerastoderma edule through chemical, physiological and biochemical tools

Alterations in Some Biochemical Responses of Freshwater Mussels in Acute Imidacloprid Exposure

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