Neurotoxicity assessment of triazole fungicides on mitochondrial oxidative respiration and lipids in differentiated human SH-SY5Y neuroblastoma cells

Sanchez, Christina L.; Souders, Christopher L.; Pena-Delgado, Carlos; Nguyen, Khaai; Kroyter, Noa; Ahmadie, Nader El; Aristizabal‐Henao, Juan J.; Bowden, John A.; Martyniuk, Christopher J.

doi:10.1016/j.neuro.2020.06.009

Cited by 46 publications

(20 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consequently, the stereoisomers of difenoconazole are expected to penetrate the blood–brain barrier and potentially produce neurotoxicity. Furthermore, there are published data exemplifying the in vitro neurotoxic effects of propiconazole and tebuconazole, which are other triazole fungicides [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole

et al. 2022

View full text Add to dashboard Cite

Difenoconazole is a chemical entity containing two chiral centers and having four stereoisomers: (2R,4R)-, (2R,4S)-, (2S,4R)- and (2S,4S)-difenoconazole, the marketed product containing a mixture of these isomers. Residues of difenoconazole have been identified in many agricultural products and drinking water. A computational approach has been used to evaluate the toxicological effects of the difenoconazole stereoisomers on humans. It integrates predictions of absorption, distribution, metabolism, excretion and toxicity (ADMET) profiles, prediction of metabolism sites, and assessment of the interactions of the difenoconazole stereoisomers with human cytochromes, nuclear receptors and plasma proteins by molecular docking. Several toxicological effects have been identified for all the difenoconazole stereoisomers: high plasma protein binding, inhibition of cytochromes, possible hepatotoxicity, neurotoxicity, mutagenicity, skin sensitization potential, moderate potential to produce endocrine disrupting effects. There were small differences in the predicted probabilities of producing various biological effects between the distinct stereoisomers of difenoconazole. Furthermore, there were significant differences between the interacting energies of the difenoconazole stereoisomers with plasma proteins and human cytochromes, the spectra of the hydrogen bonds and aromatic donor–acceptor interactions being quite distinct. Some distinguishing results have been obtained for the (2S,4S)-difenoconazole: it registered the highest value for clearance, exposed reasonable probabilities to produce cardiotoxicity and carcinogenicity and negatively affected numerous nuclear receptors.

show abstract

Section: Resultsmentioning

confidence: 99%

A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole

et al. 2022

View full text Add to dashboard Cite

show abstract

“…As shown in Figure 3 , different concentrations of acetonitrile and tebuconazole used in the experiment did not affect Caco-2 cell viability. The concentration of tebuconazole in the transfer test was higher than that of other triazole substances in the transfer test [ 33 ], which is likely due to the nature of tebuconazole [ 39 ]. The tendency of pesticide bioaccessibility may depend on the polarity of pesticide molecules, and the bioaccessibility increases with the increase in pesticide polarity.…”

Section: Resultsmentioning

confidence: 99%

Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models

Liu

Han

Xiao

et al. 2022

Foods

View full text Add to dashboard Cite

In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body.

show abstract

“…Electron transport chain (ETC) inhibition (147) 2. ATP synthase inhibition (29) 3. Redox cycling (10) 4.…”

Section: Methodsmentioning

confidence: 99%

Mechanistically driven identification of novel structural alerts for mitochondrial toxicity

Gong

Przybylak

Goodman

2021

Computational Toxicology

View full text Add to dashboard Cite

Neurotoxicity assessment of triazole fungicides on mitochondrial oxidative respiration and lipids in differentiated human SH-SY5Y neuroblastoma cells

Cited by 46 publications

References 48 publications

A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole

A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole

Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models

Mechanistically driven identification of novel structural alerts for mitochondrial toxicity

Contact Info

Product

Resources

About