Neurotoxicity of Artemisinin Derivatives

Adjei, George; Goka, Bamenla Q.; Kurtzhals, Jørgen A. L.

doi:10.1086/508883

Cited by 7 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is no evidence of added toxicity when artemisinin drugs are used in combination with other compounds. However, ACT drugs are still not ideal in term of safety, with potential neurotoxicity and neuronal degeneration observed in animals, and cell culture conditions that use artemisinin or derivatives at concentrations several times that used to treat malaria [65]. They are specifically contraindicated in early pregnancy [66].…”

Section: Pharmacokineticsmentioning

confidence: 99%

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Na‐Bangchang¹,

Karbwang

2009

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

Antimalarial drugs have played a mainstream role in controlling the spread of malaria through the treatment of patients infected with the plasmodial parasites and controlling its transmissibility. The inadequate armory of drugs in widespread use for the treatment of malaria, development of strains resistant to currently used antimalarials, and the lack of affordable new drugs are the limiting factors in the fight against malaria. In addition, other problems with some existing agents include unfavorable pharmacokinetic properties and adverse effects/toxicity. These factors underscore the continuing need of research for new classes of antimalarial agents, and a re-examination of the existing antimalarial drugs that may be effective against resistant strains. In recent years, major advances have been made in the pharmacology of several antimalarial drugs both in pharmacokinetics and pharmacodynamics aspects. These include the design, development, and optimization of appropriate dosage regimens of antimalarials, basic knowledge in metabolic pathways of key antimalarials, as well as the elucidation of mechanisms of action and resistance of antimalarials. Pharmacologists have been working in close collaboration with scientists in other disciplines of science/biomedical sciences for more understanding on the biology of the parasite, host, in order to exploit rational design of drugs. Multiple general approaches to the identification of new antimalarials are being pursued at this time. All should be implemented in parallel with focus on the rational development of new agents directed against newly identified parasite targets. With major advances in our understanding of malaria parasite biology coupled with the completion of the malaria genome, has presented exciting opportunities for target-based antimalarial drug discovery.

show abstract

Section: Pharmacokineticsmentioning

confidence: 99%

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Na‐Bangchang¹,

Karbwang

2009

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Four studies which looked for neurological damage following artemisinin exposure revealed no indication of neurotoxicity. However, in the light of recent debates about the potential ototoxicity of the artemisinins, further studies conducting thorough auditory evaluation before and after treatment may be needed [29-31]. …”

Section: Discussionmentioning

confidence: 99%

The safety of artemisinins during pregnancy: a pressing question

Dellicour

Hall

Chandramohan

et al. 2007

Malar J

View full text Add to dashboard Cite

show abstract

Current awareness: Pharmacoepidemiology and drug safety

2007

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

show abstract

Neurotoxicity of Artemisinin Derivatives

Cited by 7 publications

References 11 publications

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

Current status of malaria chemotherapy and the role of pharmacology in antimalarial drug research and development

The safety of artemisinins during pregnancy: a pressing question

Current awareness: Pharmacoepidemiology and drug safety

Contact Info

Product

Resources

About