Neurotoxicity of nanoscale materials

Karmakar, Alokita; Zhang, Qinli; Zhang, Yongbin

doi:10.1016/j.jfda.2014.01.012

Cited by 139 publications

(82 citation statements)

References 141 publications

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“…To reach the brain, CuO-NPs have to cross the blood-brain barrier (BBB) which has been demonstrated for several types of inorganic nanoparticles including CuO-NPs [19][20][21][22][23]. In addition, CuO-NPs and other inorganic nanoparticles can reach the brain via nerve axons from the olfactory bulb [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Copper Oxide Nanoparticles Stimulate Glycolytic Flux and Increase the Cellular Contents of Glutathione and Metallothioneins in Cultured Astrocytes

Bulcke

Dringen

2014

Neurochem Res

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Copper oxide nanoparticles (CuO-NPs) are frequently used for industrial or medical applications and are known for their high toxic potential. As little is known so far on the consequences of an exposure of brain cells to such particles, we applied CuO-NPs to cultured primary rat astrocytes and investigated whether such particles affect cell viability and alter their metabolic properties. Astrocytes efficiently accumulated CuO-NPs in a time- and concentration-dependent manner. The cells remained viable during a 24 h incubation with 100 µM copper in the form of CuO-NPs, while higher concentrations of CuO-NPs severely compromised the cell viability. Astrocytes that were exposed for 24 h to 100 µM CuO-NPs showed significantly enhanced extracellular lactate concentrations and increased cellular levels of glutathione and metallothioneins. The CuO-NP-induced increase in lactate release and metallothionein content were prevented by the presence of the membrane-permeable copper chelator tetrathiomolybdate, while this chelator increased already in the absence of CuO-NPs the cellular glutathione content. After removal of the CuO-NPs following a 24 h pre-incubation with 100 µM CuO-NPs, astrocytes maintained during a further 6 h incubation an elevated glycolytic lactate release and exported significantly more glutathione than control cells that had been pre-incubated without CuO-NPs. These data suggest that copper ions which are liberated from internalized CuO-NPs stimulate glycolytic flux as well as the synthesis of glutathione and metallothioneins in cultured viable astrocytes.

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Section: Introductionmentioning

confidence: 99%

Copper Oxide Nanoparticles Stimulate Glycolytic Flux and Increase the Cellular Contents of Glutathione and Metallothioneins in Cultured Astrocytes

Bulcke

Dringen

2014

Neurochem Res

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“…It has been established that exposure to nanoparticles by people working in automobile, aerospace, or paint industries [27–32] can lead to major health problems, including neurotoxicity [7]. In this context, further studies are needed in order to establish the effects on the human body by inhaled nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats

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Ciobanu

Popa

et al. 2014

BioMed Research International

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Iron oxide-silica nanoparticles (IOSi-NPs) were prepared from a mixture of ferrous chloride tetrahydrate and ferric chloride hexahydrate dropped into a silica xerogel composite. The structure and morphology of the synthesized maghemite nanoparticles into the silica xerogel were analysed by X-ray diffraction measurements, scanning electron microscopy equipped with an energy dispersive X-ray spectrometer, and transmission electron microscopy. The results of the EDAX analysis indicated that the embedded particles were iron oxide nanoparticles. The particle size of IOSi-NPs calculated from the XRD analysis was estimated at around 12.5 nm. The average size deduced from the particle size distribution is 13.7 ± 0.6 nm, which is in good agreement with XRD analysis. The biocompatibility of IOSi-NPs was assessed by cell viability and cytoskeleton analysis. Histopathology analysis was performed after 24 hours and 7 days, respectively, from the intratracheal instillation of a solution containing 0.5, 2.5, or 5 mg/kg IOSi-NPs. The pathological micrographs of lungs derived from rats collected after the intratracheal instillation with a solution containing 0.5 mg/kg and 2.5 mg/kg IOSi-NPs show that the lung has preserved the architecture of the control specimen with no significant differences. However, even at concentrations of 5 mg/kg, the effect of IOSi-NPS on the lungs was markedly reduced at 7 days posttreatment.

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“…Nanoparticles have gained considerable attention in recent years because of their broad applications for several uses, including industry, agriculture, medicine, cosmetics, and clothing. 68 Although there have been some concerns about their safety and the toxicities of various nanomaterials have been reported, [69][70][71][72][73][74][75] nanoparticle application for vaccines and immunotherapies remains very attractive. For example, vaccine delivery using nanoparticles has been recently reviewed.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases

Lin

Yang

et al. 2015

Human Vaccines & Immunotherapeutics

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Neurotoxicity of nanoscale materials

Cited by 139 publications

References 141 publications

Copper Oxide Nanoparticles Stimulate Glycolytic Flux and Increase the Cellular Contents of Glutathione and Metallothioneins in Cultured Astrocytes

Copper Oxide Nanoparticles Stimulate Glycolytic Flux and Increase the Cellular Contents of Glutathione and Metallothioneins in Cultured Astrocytes

Toxicity Evaluation following Intratracheal Instillation of Iron Oxide in a Silica Matrix in Rats

Biodegradable polymeric microsphere-based vaccines and their applications in infectious diseases

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