Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos

Zhou, Ranran; Zhou, Dao; Yang, Shixin; Shi, Zhiqiao; Pan, Hui; Jin, Qijie; Ding, Zhuhong

doi:10.1016/j.scitotenv.2023.162096

Cited by 41 publications

(5 citation statements)

References 78 publications

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“…Compared to microplastics, nanoplastics have smaller particle sizes and are more likely to enter organisms through various routes. For example, when zebrafish embryos were exposed to 100 nm, 500 nm, and 1 μm micro- and nanoplastics, large amounts of nanoplastics were found to be deposited on the chorionic surface and yolk sac of the embryos in the 100 nm and 500 nm exposed groups, and they even were observed in the brains of larvae [ 117 ]. However, in the 1 μm microplastic exposure group, microplastics were only deposited on the surface of the embryonic chorionic membrane and did not enter the embryo interior and larval brain tissue.…”

Section: Toxic Effects Of Micro- and Nanoplasticsmentioning

confidence: 99%

Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota

et al. 2023

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Emerging studies have presented an initial picture of the toxic effects of exposure to environmental micro- and nanoplastics. They have indicated that micro- and nanoplastics may induce toxicity by leading to oxidative stress, energy metabolism disorders, gene damage, and so forth in environmental organisms, marine invertebrates and vertebrates, and laboratory mouse models. In recent years, micro- and nanoplastics have been discovered in human fecal samples, placentas, lung tissue, and even blood; thus, micro- and nanoplastics pose an alarming and ever-increasing threat to global public health. However, current research on the health effects of micro- and nanoplastics and the possible adverse outcomes in humans has only presented the tip of the iceberg. More robust clinical data and basic experiments are still warranted to elucidate the specific relationships and mechanisms. In this paper, we review studies on micro- and nanoplastic toxicity from the perspectives of eco-toxicity, the adverse effects on invertebrates and vertebrates, and the impact of micro- and nanoplastics on the gut microbiota and its metabolites. In addition, we evaluate the toxicological role of micro- and nanoplastic exposure and its potential implications in respect to human health. We also summarize studies regarding preventive strategies. Overall, this review provides insights on micro- and nanoplastic toxicity and its underlying mechanisms, opening up scientific avenues for future in-depth studies.

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Section: Toxic Effects Of Micro- and Nanoplasticsmentioning

confidence: 99%

Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota

et al. 2023

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“…Neurons transmit and process signals in the brain and other nervous system parts; however, toxins can alter or disrupt these activities and at times destroy them. MNPs have been reported to accumulate in the brain [173][174][175]. In vivo studies by Shan et al demonstrated that PSNPs can induce the permeability of the blood-brain barrier, allowing their accumulation in the brain.…”

Section: Neurotoxicity Of Mnpsmentioning

confidence: 99%

“…Their work revealed that the mechanism of neuronal injury by MNPs might be through inducing abnormalities in development-related and apoptotic genes. Additionally, PS-NPs altered synaptic signaling and contribute to the development of neurotoxicity by inducing abnormalities in the neurotransmitter system [175].…”

Section: Neurotoxicity Of Mnpsmentioning

confidence: 99%

Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

Dube,

Okuthe

2023

IJERPH

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Plastics, due to their varied properties, find use in different sectors such as agriculture, packaging, pharmaceuticals, textiles, and construction, to mention a few. Excessive use of plastics results in a lot of plastic waste buildup. Poorly managed plastic waste (as shown by heaps of plastic waste on dumpsites, in free spaces, along roads, and in marine systems) and the plastic in landfills, are just a fraction of the plastic waste in the environment. A complete picture should include the micro and nano-plastics (MNPs) in the hydrosphere, biosphere, lithosphere, and atmosphere, as the current extreme weather conditions (which are effects of climate change), wear and tear, and other factors promote MNP formation. MNPs pose a threat to the environment more than their pristine counterparts. This review highlights the entry and occurrence of primary and secondary MNPs in the soil, water and air, together with their aging. Furthermore, the uptake and internalization, by plants, animals, and humans are discussed, together with their toxicity effects. Finally, the future perspective and conclusion are given. The material utilized in this work was acquired from published articles and the internet using keywords such as plastic waste, degradation, microplastic, aging, internalization, and toxicity.

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“…In living things, the particle size-dependent effects of NPs have the potential to cause biological neurotoxicity. Developmental and neurotoxic effects were seen in PS-NPs of all particle sizes, with smaller PS-NPs demonstrating more toxicity [38]. Furthermore, due to their increased specific surface area, enabling more interactions with cellular components, smaller nanoplastic particles are more likely to infiltrate cells and cause more severe cellular damage [23].…”

Section: Properties Of Plastic Pelletsmentioning

confidence: 99%

Bacterial Interactions with Nanoplastics and the Environmental Effects They Cause

Wang,

Li,

et al. 2023

Fermentation

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Recently, there has been an increase in interest in the relationship between microorganisms and micro/nanoplastics. Particularly in natural environments, bacteria play an important role. For the ecological risk assessment of plastic particles, a proper understanding of how bacteria and plastic particles interact is crucial. According to a review of the research, the interaction between bacteria and nanoplastics is primarily caused by the interaction of nanoplastics with bacterial cell membranes and the induction of oxidative stress, which can have an impact on bacterial growth, lead to alterations in biofilm production, and induce bacterial gene mutations. On a more general scale, the high concentration of nanoplastics in the environment can increase the likelihood of organic pollution reaching microbial communities, altering the gene abundance of bacteria involved in material cycling, and decreasing the activity of bacterial functional enzymes, all of which can obstruct the cycling of environmental elements. The majority of current research relies on laboratory tests, and the modeled NPs employed may be considerably dissimilar from those found in the environment. In order to provide a guide for environmental management in the future, it will be necessary to analyze the effects of nanoplastics and bacteria on the environment under actual environmental conditions to help us comprehend the relationship between nanoplastics and bacteria and their ecological impacts.

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Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos

Cited by 41 publications

References 78 publications

Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota

Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota

Plastics and Micro/Nano-Plastics (MNPs) in the Environment: Occurrence, Impact, and Toxicity

Bacterial Interactions with Nanoplastics and the Environmental Effects They Cause

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