Neurotransmitter imbalance in serum of psoriatic patients in exacerbation stage with comorbid psychoemotional disorders

Matiushenko, Valeriia; Kutasevych, Yanina; Jafferany, Mohammad

doi:10.1111/dth.13337

Cited by 11 publications

(11 citation statements)

References 10 publications

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“…Furthermore, neurotransmitters may affect the composition of the gut microbiome, a recently appreciated factor in psoriasis ( Chen et al, 2020 ). Lastly, decreased GABA serum levels were noted in a majority of psoriasis patients with psycho-emotional disorders, a common comorbidity affecting psoriasis patients ( Matiushenko et al, 2020 ). However, in the here presented study, no information on emotional health was collected.…”

Section: Discussionmentioning

confidence: 99%

DNA Methylation Patterns in CD8+ T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity

Charras

Garau

Hofmann

et al. 2021

Front. Cell Dev. Biol.

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Background: Psoriasis is a T cell-mediated chronic autoimmune/inflammatory disease. While some patients experience disease limited to the skin (skin psoriasis), others develop joint involvement (psoriatic arthritis; PsA). In the absence of disease- and/or outcome-specific biomarkers, and as arthritis can precede skin manifestations, diagnostic and therapeutic delays are common and contribute to disease burden and damage accrual.Objective: Altered epigenetic marks, including DNA methylation, contribute to effector T cell phenotypes and altered cytokine expression in autoimmune/inflammatory diseases. This project aimed at the identification of disease-/outcome-specific DNA methylation signatures in CD8+ T cells from patients with psoriasis and PsA as compared to healthy controls.Method: Peripheral blood CD8+ T cells from nine healthy controls, 10 psoriasis, and seven PsA patients were collected to analyze DNA methylation marks using Illumina Human Methylation EPIC BeadChips (>850,000 CpGs per sample). Bioinformatic analysis was performed using R (minfi, limma, ChAMP, and DMRcate packages).Results: DNA methylation profiles in CD8+ T cells differentiate healthy controls from psoriasis patients [397 Differentially Methylated Positions (DMPs); 9 Differentially Methylated Regions (DMRs) when ≥CpGs per DMR were considered; 2 DMRs for ≥10 CpGs]. Furthermore, patients with skin psoriasis can be discriminated from PsA patients [1,861 DMPs, 20 DMRs (≥5 CpGs per region), 4 DMRs (≥10 CpGs per region)]. Gene ontology (GO) analyses considering genes with ≥1 DMP in their promoter delivered methylation defects in skin psoriasis and PsA primarily affecting the BMP signaling pathway and endopeptidase regulator activity, respectively. GO analysis of genes associated with DMRs between skin psoriasis and PsA demonstrated an enrichment of GABAergic neuron and cortex neuron development pathways. Treatment with cytokine blockers associated with DNA methylation changes [2,372 DMPs; 1,907 DMPs within promoters, 7 DMRs (≥5 CpG per regions)] affecting transforming growth factor beta receptor and transmembrane receptor protein serine/threonine kinase signaling pathways. Lastly, a methylation score including TNF and IL-17 pathway associated DMPs inverse correlates with skin disease activity scores (PASI).Conclusion: Patients with skin psoriasis exhibit DNA methylation patterns in CD8+ T cells that allow differentiation from PsA patients and healthy individuals, and reflect clinical activity of skin disease. Thus, DNA methylation profiling promises potential as diagnostic and prognostic tool to be used for molecular patient stratification toward individualized treatment.

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Section: Discussionmentioning

confidence: 99%

DNA Methylation Patterns in CD8+ T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity

Charras

Garau

Hofmann

et al. 2021

Front. Cell Dev. Biol.

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“…The greater potency of these new drugs as compared to the traditional systemic agents for example, methotrexate, acitretin and cyclosporine, etc. highlights the significance of IL‐23 in the amplification of the immune response and has supported the role of Th17 cell type as the most dominant T cell subset in psoriasis 17‐21 …”

Section: Introductionmentioning

confidence: 89%

“…highlights the significance of IL-23 in the amplification of the immune response and has supported the role of Th17 cell type as the most dominant T cell subset in psoriasis. [17][18][19][20][21] Naive T-cells upon activation transform into Th1, Th2, Th17, and T regulatory cells. Each of these subsets in turn produces certain cytokines and lymphokines like Interferon-gamma (IFN-γ), TNF-α, and TNF-β.…”

mentioning

confidence: 99%

Interleukin 23p19 inhibitors in chronic plaque psoriasis with focus on mirikizumab: A narrative review

Salimi

Yamauchi

Thakur

et al. 2020

Dermatologic Therapy

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Psoriasis, a T‐cell mediated chronic dermatosis, has a complex etiopathogenesis. There has been extensive research into the aberrant immune response, which leads to the formation of clinical lesions, and the need for developing better and safer drugs has been unrelenting. The past two decades of research has opened up new areas of the immune pathway that can be targeted in order to control the disease. Therefore, we have seen the emergence of biologics which either target T‐cell receptors or inhibit Tumor Necrosis Factor‐alpha (TNF‐α) or inhibit interleukins (IL) like IL‐12, IL‐17, IL‐17 receptor, and more recently IL‐23. Drugs specifically targeting the p19 subunit of IL‐23 have shown promising results in the management of chronic plaque psoriasis. This has given way to the development of a new class of biologics, that is, the IL‐23p19 inhibitors that have a better safety profile as compared to its predecessors. In this review, we shall scrutinize the role of IL‐23 and Th17 cell signaling in the evolution of the psoriatic lesions and summarize the clinical experience with IL‐23p19 inhibitors especially mirikizumab in the treatment of chronic plaque psoriasis.

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“…As for GABA, which is an inhibitory neurotransmitter, its decrease was noted in the majority of psoriasis patients with psychoemotional disorders. The obtained data indicate the need for a differential approach to the treatment of comorbid psychoemotional disorders in patients with psoriasis [ 71 ].…”

Section: The Association Between Psoriasis and Depressionmentioning

confidence: 99%

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

Marek-Józefowicz

Czajkowski

Borkowska

et al. 2022

IJMS

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Psoriasis is a chronic inflammatory skin disease with systemic manifestation, in which psychological factors play an important role. The etiology of psoriasis is complex and multifactorial, including genetic background and environmental factors such as emotional or physical stress. Psychological stress may also play a role in exacerbation of psoriasis, by dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, sympathetic–adrenal–medullary axis, peripheral nervous system, and immune system. Skin cells also express various neuropeptides and hormones in response to stress, including the fully functional analog of the HPA axis. The deterioration of psoriatic lesions is accompanied by increased production of inflammatory mediators, which could contribute to the imbalance of neurotransmitters and the development of symptoms of depression and anxiety. Therefore, deregulation of the crosstalk between endocrine, paracrine, and autocrine stress signaling pathways contributes to clinical manifestations of psoriasis, which requires multidisciplinary approaches.

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Neurotransmitter imbalance in serum of psoriatic patients in exacerbation stage with comorbid psychoemotional disorders

Cited by 11 publications

References 10 publications

DNA Methylation Patterns in CD8+ T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity

DNA Methylation Patterns in CD8+ T Cells Discern Psoriasis From Psoriatic Arthritis and Correlate With Cutaneous Disease Activity

Interleukin 23p19 inhibitors in chronic plaque psoriasis with focus on mirikizumab: A narrative review

The Brain–Skin Axis in Psoriasis—Psychological, Psychiatric, Hormonal, and Dermatological Aspects

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