Neurotransmitter, opiodergic system, steroid-hormone interaction and involvement in the replacement therapy of sexual disorders

Frajese, Gaetano; Lazzari, Renato; Magnani, Armando; Moretti, Costanzo; Sforza, Vincenzo; Nerozzi, Dina

doi:10.1016/0960-0760(90)90492-4

Cited by 21 publications

(9 citation statements)

References 30 publications

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“…Studies and reviews have attributed antidepressantinduced orgasm dysfunction to α-adrenergic blockade, anticholinergic effects, or sertonergic effects. 10, [26][27][28] Sexual dysfunction subsequent to treatment with TCA and MAOI antidepressants was well documented before the launch of any of the newer-generation agents. 26, [28][29][30][31][32][33][34] Clinical efficacy trials of most of the newer antidepressants also report sexual dysfunction as an adverse effect.…”

Section: Sexual Dysfunction As An Antidepressant Adverse Effectmentioning

confidence: 99%

Antidepressant-Induced Sexual Dysfunction

et al. 2002

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Sexual dysfunction is a common adverse effect of antidepressant treatment. Physicians should monitor their patients for antidepressant-induced sexual adverse effects, as these may affect compliance with therapy and ultimate treatment success. In addition to the consequences for patient health and well-being, managed-care organizations should be concerned with sexually related adverse effects of antidepressants, insofar as additional healthcare resources may be required to treat depressed patients in whom these adverse effects arise.

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Section: Sexual Dysfunction As An Antidepressant Adverse Effectmentioning

confidence: 99%

Antidepressant-Induced Sexual Dysfunction

et al. 2002

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“…Since L-DOPA is always administered with a peripheral decarboxylase inhibitor, the mechanism of action of dopamine on sexual response is necessarily related to its central effects. 39 Treatment of hyperprolactinemia with dopamine agonists often results in rapid improvement of sexual symptoms. 40 In addition, dopamine-blocking agents such as haloperidol and chlorpromazine used for psychotic conditions often result in a reduction in sexual activity.…”

Section: Cns Pathway Of Sexual Dysfunctionmentioning

confidence: 99%

Epidemiology and pathophysiology of male sexual dysfunction

Kaminetsky

2008

Int J Impot Res

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Male sexual dysfunction (MSD) is a common disorder associated with a wide range of physical and psychological conditions. Erectile dysfunction, the most commonly studied aspect of MSD, is common and increases with age and with certain comorbid conditions. The pathophysiology of ED and other forms of MSD can be traced to a variety of etiologies, including vascular, hormonal, psychiatric, iatrogenic and potentially neurobiological causes.

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“…Indeed, some investigators propose that the principal action of androgens in human sexual function mainly or solely involves the control of libido at the level of the central nervous system rather than any direct effect on erectile tissue [26]. Frajese et al [17] emphasize the fundamental role of testosterone in the CNS, where it activates the sexual stimulatory dopaminergic system and inhibits the inhibitory serotonergic system.…”

Section: R Shabsighmentioning

confidence: 98%

The effects of testosterone on the cavernous tissue and erectile function

Shabsigh

1997

World J Urol

151

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A review of the current literature is conducted to explore the developmental aspects, animal and human experiences and the effects of pharmacological manipulation to explain the role androgens play in sexual function with special emphasis on erectile function and the erectile tissue. This review reveals that androgens are necessary for the normal development of the penis and their deficiency results in significant structural abnormalities. Although androgen receptors in the penis decrease after puberty, they usually do not disappear completely. Animal data show that androgens support erectile function through a direct effect on the erectile tissue. Experimental castration results in impaired erectile response to central and peripheral stimulation and decrease in penile tissue concentration of nitric oxide synthase-containing nerves. Testosterone replacement reverses these abnormalities. In the rat penis, apoptosis is induced by castration and new DNA synthesis is induced by testosterone replenishment. Human data are less clear than animal data. Castration results in loss of libido and in erectile dysfunction. However, these effects are not universal. Testosterone enhances libido, frequency of sexual acts and sleep-related erections. Its effects on erotic erections are not clear.

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Neurotransmitter, opiodergic system, steroid-hormone interaction and involvement in the replacement therapy of sexual disorders

Cited by 21 publications

References 30 publications

Antidepressant-Induced Sexual Dysfunction

Antidepressant-Induced Sexual Dysfunction

Epidemiology and pathophysiology of male sexual dysfunction

The effects of testosterone on the cavernous tissue and erectile function

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