Neurotransmitter regulation of circadian structural changes in the fly's visual system

Meinertzhagen, Ian A.; Pyza, Elżbieta

doi:10.1002/(sici)1097-0029(19990415)45:2<96::aid-jemt4>3.0.co;2-l

Cited by 42 publications

(23 citation statements)

References 71 publications

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“…These serotonergic processes have varicosities among monopolar cells bodies distal to the lamina in all fly species studied (Nässel 1991). Experimental work on houseflies suggest that these serotonergic processes can modulate photoreceptors and maybe lamina circuits (Chen et al 1999;Meinertzhagen and Pyza 1999;Pyza and Meinertzhagen 1996). Thus, it is likely that if there were peptidergic processes in the same region, these should be able to release peptide that could act on lamina circuits.…”

Section: Patterns Of Neuropeptide and Receptor Distribution In Drosopsupporting

confidence: 81%

“…Thus, it is likely that if there were peptidergic processes in the same region, these should be able to release peptide that could act on lamina circuits. Indeed, this has been suggested from experiments in houseflies where PDF expressing processes are found near the lamina synaptic region and injected PDF induces changes in lamina neuron morphology reminiscent of those seen during the daily rhythm (Meinertzhagen and Pyza 1999;Pyza and Meinertzhagen 1996). In Drosophila, however, the only peptide action on lamina neurons that is feasible (with the present data) is via peptidergic neurons in the medulla acting on the terminations of lamina-medulla neurons (or on medulla dendrites of centrifugal medulla-lamina neurons).…”

Section: Patterns Of Neuropeptide and Receptor Distribution In Drosopmentioning

confidence: 99%

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Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

Nässel

2009

Invert Neurosci

105

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Neuropeptide signaling is functionally very diverse and one and the same neuropeptide may act as a circulating neurohormone, as a locally released neuromodulator or even as a cotransmitter of classical fast-acting neurotransmitters. Thus, neuropeptides are produced by a huge variety of neuron types in different parts of the nervous system. Within the central nervous system (CNS) there are numerous types of peptidergic interneurons, some with strictly localized and patterned branching morphologies, others with widespread and diffuse arborizations. From morphology alone it is often difficult to predict the sphere of influence of a peptidergic interneuron, especially since it has been shown that neuropeptides can diffuse over tens of micrometers within neuropils, and that peptides probably are released exclusively in perisynaptic (or non-synaptic) regions. This review addresses some questions related to peptidergic signaling in the insect CNS. How diverse are the spatial relations between peptidergic neurons and their target neurons and what determines the sphere of functional influence? At one extreme there is volume transmission and at the other targeted cotransmission at synapses. Also temporal aspects of peptidergic signaling are of interest: how transient are peptidergic messages? Factors important for these spatial and temporal aspects of peptidergic signaling are proximity between release sites and cognate receptors, distribution of peptidase activity that can terminate peptide action and colocalization of other neuroactive compounds in the presynaptic peptidergic neuron (and corresponding receptors in target neurons). Other factors such as expression of different channel types, receptor inactivation mechanisms and second messenger systems probably also contribute to the diversity in temporal properties of peptide signaling.

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Section: Patterns Of Neuropeptide and Receptor Distribution In Drosopsupporting

confidence: 81%

Section: Patterns Of Neuropeptide and Receptor Distribution In Drosopmentioning

confidence: 99%

Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

Nässel

2009

Invert Neurosci

105

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“…Note that immunolabeling with the two antisera is not identical, but similar bodies of the lamina monopolar neurons. This layer is presumed to be devoid of synaptic contacts (Meinertzhagen and O'Neil 1991;Meinertzhagen and Pyza 1999;Nässel and Elekes 1984;Pyza and Meinertzhagen 1997), and thus the neurons might release MIP in a paracrine fashion.…”

Section: Mip-expressing Neurons In the Optic Lobe Of Drosophilamentioning

confidence: 99%

“…Nevertheless, neurons of the Drosophila lamina have been demonstrated to display cyclic variations in morphology and physiology that appear to be under the control of clock neurons (GorskaAndrzejak et al 2005(GorskaAndrzejak et al , 2009Meinertzhagen and Pyza 1999;Pyza and Meinertzhagen 1995, 1997Weber et al 2009), suggesting that other interneurons connect the oscillators to the periphery. One set of candidate neurons for the central modulation of lamina circuits was identified before the clock neurons had been localized.…”

Section: Introductionmentioning

confidence: 99%

A novel wide-field neuron with branches in the lamina of the Drosophila visual system expresses myoinhibitory peptide and may be associated with the clock

Kołodziejczyk

Nässel

2010

Cell Tissue Res

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Although neuropeptides are widespread throughout the central nervous system of the fruifly Drosophila, no records exist of peptidergic neurons in the first synaptic region of the visual system, the lamina. Here, we describe a novel type of neuron that has wide-field tangential arborizations just distal to the lamina neuropil and that expresses myoinhibitory peptide (MIP). The cell bodies of these neurons, designated lateral MIP-immunoreactive optic lobe (LMIo) neurons, lie anteriorly at the base of the medulla of the optic lobe. The LMIo neurons also arborize in several layers of the medulla and in the dorso-lateral and lateral protocerebrum. Since the LMIo resemble LN(v) clock neurons, we have investigated the relationships between these two sets of neurons by combining MIP-immunolabeling with markers for two of the clock genes, viz., Cryptochrome and Timeless, or with antisera to two peptides expressed in clock neurons, viz., pigment-dispersing factor and ion transport peptide. LMIo neurons do not co-express any of these clock neuron markers. However, branches of LMIo and clock neurons overlap in several regions. Furthermore, the varicose lamina branches of LMIo neurons superimpose those of two large bilateral serotonergic neurons. The close apposition of the terminations of MIP- and serotonin-producing neurons distal to the lamina suggests that they have the same peripheral targets. Our data indicate that the LMIo neurons are not bona fide clock neurons, but they may be associated with the clock system and regulate signaling peripherally in the visual system.

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“…Moreover, recent studies have provided evidence that PDF acts as a chronobiological signaling substance per se . The group of PDH-IR somata located at the anterior-most part of the lobula may be considered as homologues to the LNv of D. melanogaster (Meinertzhagen and Pyza 1999). PDF is reported to affect the migration of the screening pigment granules of the photoreceptor terminals (Pyza and Meinertzhagen 1997).…”

Section: Pdh-li Distribution Patternmentioning

confidence: 99%

FMRFamide-like immunocytochemistry in the brain and subesophageal ganglion of Triatoma infestans (Insecta: Heteroptera). Coexpression with β-pigment-dispersing hormone and small cardioactive peptide B

Settembrini

Villar

2005

Cell Tissue Res

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The distribution of FMRFamide (FMRFa)-like immunoreactivity (LI) was studied in the brain and subesophageal ganglion of Triatoma infestans, the insect vector of Chagas' disease. The neuropeptide displayed a widespread distribution with immunostained somata in the optic lobe, in the anterior, lateral, and posterior soma rinds of the protocerebrum, and around the antennal sensory and mechanosensory and motor neuropils of the deutocerebrum. FMRFa-immunoreactive profiles of the subesophageal ganglion were seen in the mandibular, maxillary, and labial neuromeres. Immunostained neurites were detected in the medulla and lobula of the optic lobe, the lateral protocerebral neuropil, the median bundle, the calyces and the stalk of the mushroom bodies, and the central body. In the deutocerebrum, the sensory glomeruli showed a higher density of immunoreactive processes than the mechanosensory and motor neuropil, whereas the neuropils of each neuromere of the subesophageal ganglion displayed a moderate density of immunoreactive neurites. Colocalization of FMRFa-LI and crustacean pigment-dispersing hormone-LI was found in perikarya of the proximal optic lobe, the lobula, the sensory deutocerebrum, and the labial neuromere of the subesophageal ganglion. The distribution pattern of small cardioactive peptide B (SCP(B))-LI was also widespread, with immunolabeled somata surrounding every neuropil region of the brain and subesophageal ganglion, except for the optic lobe. FMRFa- and SCP(B)-LIs showed extensive colocalization in the brain of this triatomine species. The presence of immunolabeled perikarya displaying either FMRFa- or SCP(B)-LI confirmed that each antisera identified different peptide molecules. The distribution of FMRFa immunostaining in T. infestans raises the possibility that FMRFa plays a role in the regulation of circadian rhythmicity. The finding of immunolabeling in neurosecretory somata of the protocerebrum suggests that this neuropeptide may also act as a neurohormone.

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Neurotransmitter regulation of circadian structural changes in the fly's visual system

Cited by 42 publications

References 71 publications

Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

Neuropeptide signaling near and far: how localized and timed is the action of neuropeptides in brain circuits?

A novel wide-field neuron with branches in the lamina of the Drosophila visual system expresses myoinhibitory peptide and may be associated with the clock

FMRFamide-like immunocytochemistry in the brain and subesophageal ganglion of Triatoma infestans (Insecta: Heteroptera). Coexpression with β-pigment-dispersing hormone and small cardioactive peptide B

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