2022
DOI: 10.1038/s41388-022-02479-4
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Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment

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Cited by 19 publications
(8 citation statements)
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“…Furthermore, in pathological conditions such as CRC, there is often dysregulation of neurotransmitters, which can impact intestinal function and homeostasis 26 . Over the course of CRC progression, both cancer cells and neurons within the enteric nervous system of the intestine release neurotransmitters that have the potential to influence signaling pathways and promote the survival of cancer cells 65 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Furthermore, in pathological conditions such as CRC, there is often dysregulation of neurotransmitters, which can impact intestinal function and homeostasis 26 . Over the course of CRC progression, both cancer cells and neurons within the enteric nervous system of the intestine release neurotransmitters that have the potential to influence signaling pathways and promote the survival of cancer cells 65 .…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, biophysical cues from the TME can impact cell signaling, gene expression, and even therapeutic responses 12, 24 . Recent studies suggest that alterations in neurotransmitter signaling within the gut may contribute to the initiation and progression of colorectal cancer (CRC) 25, 26 . Dysregulation of serotonin, for instance, has been linked to changes in gut motility and inflammation, which can create an environment conducive to CRC development 27, 28 .…”
Section: Introductionmentioning
confidence: 99%
“…The mechanism of Ca 2+ channels acting on tumor is complex and can affect tumor progression from multiple aspects. It has been reported that Ca 2+ could activate NF-κB, NFAT, and CREB pathways, thereby playing an important role in tumor immunity cells and progression [ 24 , 25 ]. Moreover, the high-risk group exhibited a significant enrichment of pathways associated with poor tumor prognosis, including “E2F targets pathway”, “G2M checkpoint pathway”, “MTORC1 signaling pathway”, “MYC targets pathway”, and “RIBOSOME” based on GSEA analysis ( Figure 7 I,J) [ 26 , 27 , 28 , 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…The aberrant expression of neurotransmitter signaling genes in colorectal cancer underscores the potential of neurotransmitters to enhance tumor growth and metastasis by stimulating processes such as cell proliferation, migration, invasion, and angiogenesis. In addition, neurotransmitters can influence immune cells and endothelial cells in the tumor microenvironment, fostering inflammation and contributing to the advancement of tumor growth ( Battaglin et al, 2022 ). Nevertheless, the precise impact of various neurotransmitter receptors on colorectal cancer progression remains poorly understood.…”
Section: Discussionmentioning
confidence: 99%