Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro

Kim, Nam-Ho; Kim, Soohyun; Kim, Yujin; Kim, Jeong-Ki; Nam, Min-Kyung; Rhim, Hyangshuk; Yoon, Sungjoo Kim; Choi, Sang-Zin; Son, Miwon; Kim, Sun Yeou; Kuh, Hyo-Jeong

doi:10.1016/j.jep.2011.05.032

Cited by 35 publications

(28 citation statements)

References 31 publications

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“…In that study, Kim et al reported that DA-9801 had a significant effect on neurite outgrowth and phosphorylation of TrkA, a high-affinity catalytic receptor for NGF (Kim et al, 2011b). In this study, we also found that DA-9801 increased neurite outgrowth and NGF target gene Tieg1/Klf10 mRNA expression in PC12 cells.…”

Section: Discussionsupporting

confidence: 78%

“…10-1341692-0000). NGF agonistic activities of DA-9801 in PC12 cells and dorsal root ganglion neurons were recently reported (Kim et al, 2011b). Jin et al also reported that oral treatment with DA-9801 had therapeutic potential for peripheral neuropathy in a representative type 1 diabetic animal model, STZ-induced diabetic rats (Jin et al, 2013).…”

Section: Original Articlementioning

confidence: 91%

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Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice

Moon¹,

Lee²,

Kang³

et al. 2014

Biomol Ther

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. www.biomolther.orgThe purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study.

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Section: Discussionsupporting

confidence: 78%

Section: Original Articlementioning

confidence: 91%

Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice

Moon¹,

Lee²,

Kang³

et al. 2014

Biomol Ther

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show abstract

“…18) Dried DJ and DN were purchased at a specialized market for traditional herbal medicine (Kyungdong herb market, Seoul, Korea) and their identity was confirmed by Dr. Changsoo Yuk (a specialist in plant classification, Kyung Hee University). The voucher specimen was deposited at Dong-A Pharmaceutical (Youngin-shi, Korea).…”

Section: Methodsmentioning

confidence: 99%

“…[14][15][16] To avoid the side effects, development of orally active small molecules that potentiate the expression and activity of NGF is warranted. 17,18) The extracts of plants from the Dioscorea genus were reported to exhibit hypoglycemic, 19) immunostimulatory, 20) and anti-inflammatory effects, 21) as well as anti-tumor 22) and anti-osteoporotic activity. 23) Dioscorea japonica THUNBERG.…”

mentioning

confidence: 99%

“…While the rhizome extracts showed a significant effect on neurite outgrowth and Trk-A phosphorylation in neurons, it remains to be determined whether DA-9801 possesses these neurotrophic properties. 18,25) NGF is known to interact with two receptor proteins, TrkA and p75 NTR . 26,27) NGF signaling through TrkA elicits many of the classical neurotrophic actions ascribed to NGF.…”

mentioning

confidence: 99%

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