Neurotrophic Factors in Autonomic Nervous System Plasticity and Dysfunction

Mattson, Mark P.; Wan, Ruiqian

doi:10.1007/s12017-007-8021-y

Cited by 20 publications

(20 citation statements)

References 162 publications

(143 reference statements)

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“…Nerve cells in the brain are remarkably responsive to exercise. Studies of animal models and of human subjects support the hypothesis that exercise induces the expression of neurotrophic factors which, in turn, promote structural and functional plasticity of neurons and their resistance to injury and disease (Gomez-Pinilla, 2008; Mattson and Wan, 2008; Zoladz and Pilc, 2010). BDNF has been the most intensively studied exercise-induced neurotrophic factor.…”

Section: Neurotrophic Factors Mediate Anti-aging Effects Of Endurancementioning

confidence: 94%

Evolutionary aspects of human exercise—Born to run purposefully

Mattson

2012

Ageing Research Reviews

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This article is intended to raise awareness of the adaptive value of endurance exercise (particularly running) in the evolutionary history of humans, and the implications of the genetic disposition to exercise for the aging populations of modern technology-driven societies. The genome of Homo sapiens has evolved to support the svelte phenotype of an endurance runner, setting him/her apart from all other primates. The cellular and molecular mechanisms underlying the competitive advantages conferred by exercise capacity in youth can also provide a survival benefit beyond the reproductive period. These mechanisms include up-regulation of genes encoding proteins involved in protecting cells against oxidative stress, disposing of damaged proteins and organelles, and enhancing bioenergetics. Particularly fascinating are the signaling mechanisms by which endurance running changes the structure and functional capabilities of the brain and, conversely, the mechanisms by which the brain integrates metabolic, cardiovascular and behavioral responses to exercise. As an emerging example, I highlight the roles of brain-derived neurotrophic factor (BDNF) as a mediator of the effects of exercise on the brain, and BDNF s critical role in regulating metabolic and cardiovascular responses to endurance running. A better understanding of such healthspan-extending actions of endurance exercise may lead to new approaches for improving quality of life as we advance in the coming decades and centuries.

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Section: Neurotrophic Factors Mediate Anti-aging Effects Of Endurancementioning

confidence: 94%

Evolutionary aspects of human exercise—Born to run purposefully

Mattson

2012

Ageing Research Reviews

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“…BDNF is known to play an important role in regulating the survival of neurons in the autonomic nervous system and the formation of their synaptic connectivity with their peripheral targets in the cardiovascular, digestive, and other organ systems. Emerging evidence suggests that BDNF may also affect the function of the autonomic nervous system during adult life and may, in part, mediate the effects of environmental factors, such as exercise and dietary energy intake, on autonomic nervous system neurons and target cells [53]. BDNF has also been shown to be a modulator of visceral sensory transmission, suggesting that BDNF is involved in maturation and/or plasticity in the arterial baroreceptor pathway [54].…”

Section: Mir-132 Has Functions In the Cardiovascular Systemmentioning

confidence: 99%

MicroRNA-132 may play a role in coexistence of depression and cardiovascular disease: A hypothesis

2013

Med Sci Monit

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Different individuals have different degrees of neuroplasticity due to their different experiences. Neuroplasticity may play a role in individual differences among neuropsychiatric disease treatment efficacy. Since the nervous system monitors and coordinates internal organ function, neuroplasticity may be associated with other diseases. Cardiovascular disease (CVD) is associated with depression, which is a disorder of disrupted neuroplasticity. MicroRNA-132 (miR-132) has a roles in neuroplasticity and cardiovascular function. Thus, we hypothesize that miR-132 may play a role in coexistence of depression and CVD.

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“…Neurotrophic factors play a crucial role in regulating neurons in the ANS, and in the formation of synaptic connections with peripheral targets in the cardiovascular, digestive, and other organ systems during development. They also influence the function of the ANS in adults ( 11 ). Neurotrophic factors, including brain-derived neurotrophic factor (BDNF), nerve growth factor, insulin-like growth factor (IGF), and ciliary neurotrophic factor may regulate ANS functions ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

“…They also influence the function of the ANS in adults ( 11 ). Neurotrophic factors, including brain-derived neurotrophic factor (BDNF), nerve growth factor, insulin-like growth factor (IGF), and ciliary neurotrophic factor may regulate ANS functions ( 11 ). Recent studies have found that BDNF and IGF-1 can modify the functions of the central nervous system (CNS) that are involved in neurological and psychiatric diseases, including epilepsy ( 12 – 14 ).…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 Are Associated With Autonomic Dysfunction and Impaired Cerebral Autoregulation in Patients With Epilepsy

et al. 2018

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Background: Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) may regulate the autonomic nervous system (ANS) in epilepsy. The present study investigated the role of IGF-1 and BDNF in the regulation of autonomic functions and cerebral autoregulation in patients with epilepsy.Methods: A total of 57 patients with focal epilepsy and 35 healthy controls were evaluated and their sudomotor, cardiovagal, and adrenergic functions were assessed using a battery of ANS function tests, including the deep breathing, Valsalva maneuver, head-up tilting, and Q-sweat tests. Cerebral autoregulation was measured by transcranial doppler during the breath-holding test and the Valsalva maneuver. Interictal serum levels of BDNF and IGF-1 were measured with enzyme-linked immunosorbent assay kits.Results: During interictal period, reduced serum levels of BDNF and IGF-1, impaired autonomic functions, and decreased cerebral autoregulation were noted in patients with epilepsy compared with healthy controls. Reduced serum levels of BDNF correlated with age, adrenergic and sudomotor function, overall autonomic dysfunction, and the autoregulation index calculated in Phase II of the Valsalva maneuver, and showed associations with focal to bilateral tonic-clonic seizures. Reduced serum levels of IGF-1 were found to correlate with age and cardiovagal function, a parameter of cerebral autoregulation (the breath-hold index). Patients with a longer history of epilepsy, higher seizure frequency, and temporal lobe epilepsy had lower serum levels of IGF-1.Conclusions: Long-term epilepsy and severe epilepsy, particularly temporal lobe epilepsy, may perturb BDNF and IGF-1 signaling in the central autonomic system, contributing to the autonomic dysfunction and impaired cerebral autoregulation observed in patients with focal epilepsy.

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Neurotrophic Factors in Autonomic Nervous System Plasticity and Dysfunction

Cited by 20 publications

References 162 publications

Evolutionary aspects of human exercise—Born to run purposefully

Evolutionary aspects of human exercise—Born to run purposefully

MicroRNA-132 may play a role in coexistence of depression and cardiovascular disease: A hypothesis

Serum Levels of Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor 1 Are Associated With Autonomic Dysfunction and Impaired Cerebral Autoregulation in Patients With Epilepsy

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