Neurotrophic Factors in the Pathogenesis and Treatment of Diabetic Neuropathy

Calcutt, Nigel A.

doi:10.1007/978-3-031-15613-7_8

Contemporary Diabetes

2023

DOI: 10.1007/978-3-031-15613-7_8

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Neurotrophic Factors in the Pathogenesis and Treatment of Diabetic Neuropathy

Nigel A. Calcutt

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2024

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Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy

Pham

2024

J of Diabetes Invest

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Diabetic neuropathy is one of the most serious and common complications of diabetes with a wide spectrum, affecting 30–50% of diabetic patients. However, the current treatments of this disorder, mainly based on controlling blood glucose level, show an inadequate clinical outcome. Better approaches are needed. In this fashion, it is noted that promoting nerve regeneration and preventing nerve degeneration should be focused on equally and appropriately. In this mini review, how more effective approaches are in targeting PI3K/AKT and MEK/ERK pathways in the treatment of peripheral diabetic neuropathy is discussed. Future treatment of peripheral diabetic neuropathy should consider these approaches.

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Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy

Pham

2024

J of Diabetes Invest

View full text Add to dashboard Cite

show abstract

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Neurotrophic Factors in the Pathogenesis and Treatment of Diabetic Neuropathy

Cited by 1 publication

References 347 publications

Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy

Targeting PI3K/AKT and MEK/ERK pathways for synergic effects on improving features of peripheral diabetic neuropathy

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