Neurotrophin expression of laryngeal muscles in response to recurrent laryngeal nerve transection

Abstract

Results suggest that the TA and PCA muscles respond differently to denervation.

Laryngeal EMG: Preferential damage of the posterior cricoarytenoid muscle branches especially in iatrogenic recurrent laryngeal nerve lesions

“…However, the difference between the muscles seems to persist, which partly might be explained by greater initial damage of PCA nerve branches but could also be due to preferential TA reinnervation as described by Woodson in a cat model with complete RLN transection . The reason for this could be related to differences in expressions of different neurotrophins …”

Functional regeneration of the transected recurrent laryngeal nerve using a collagen scaffold loaded with laminin and laminin-binding BDNF and GDNF

“…However, the use of a biological scaffold alone is not sufficient to achieve complete nerve repair. Neurotrophic factors are known to modulate the differentiation, survival and regeneration of PNS neurons39. In order to prevent the rapid diffusion of recombinant neurotrophins in the extracellular space, researchers have incorporated neurotrophic factors into fusion proteins.…”

Laryngeal Muscle Response to Neuromuscular Diseases and Specific Pathologies

“…Using immunohistochemistry to track the expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 4 (NT-4) the investigators noted that neurotrophin expression in the TA and PCA responded differentially to denervation over time. For the TA, NGF levels were initially decreased, but rebounded after 6 weeks post-injury (Vega-Cordova et al 2010 ) . Both BDNF and NT-4 expression were unchanged 3 days following denervation and 6 weeks post-injury in the TA.…”

“…Several recent studies have characterized the morphology of laryngeal muscles following denervation (Miyamaru et al 2008 ;Vega-Cordova et al 2010 ;Romo and Curtin 1999 ;Woodson et al 2008 ;Xu et al 2009 ) , yet our current appreciation of laryngeal muscle fi ber typing and morphological changes as a function of denervation remains incomplete. What literature does exist is suggestive of important differences in fi ber type composition and plasticity of ILM following denervation and repair in animal models.…”

“…For example, a recent report by Vega-Cordova et al ( 2010 ) described changes to three neurotrophic factors in the TA and PCA muscle following experimental denervation of the RLN. Using immunohistochemistry to track the expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and neurotrophin 4 (NT-4) the investigators noted that neurotrophin expression in the TA and PCA responded differentially to denervation over time.…”