Neurotrophin levels in different regions of the placenta and their association with birth outcome and blood pressure

Sahay, Akriti S; Sundrani, Deepali; Wagh, Girija; Mehendale, Savita; Joshi, Sadhana

doi:10.1016/j.placenta.2015.06.006

Cited by 28 publications

(17 citation statements)

References 44 publications

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“…In addition, we are not aware of any study that assessed NT-4 levels in the newborn. However, we do know that the placenta and decidual tissues are capable of synthesizing BDNF,[70, 71] and bFGF,[12, 72] and that placental insufficiency has been associated with altered expression of BDNF in the brain of the offspring (at least in sheep[10] and guinea pigs[11]), and low placenta expression of bFGF. [12]…”

Section: Discussionmentioning

confidence: 99%

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

et al. 2017

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Aim To identify the antecedents and very early correlates of low concentrations of neurotrophic growth factors in the blood of extremely preterm newborns during the first postnatal month. Methods Using an immunobead assay, we measured the concentrations of neurotrophin 4 (NT4), brain-derived neurotrophic factor (BDNF), and basic fibroblast growth factor (bFGF) in blood spots collected on postnatal days 1(N=1062), 7 (N=1087), 14 (N=989), 21 (N = 940) and 28 (N = 880) from infants born before the 28th week of gestation. We then sought the correlates of measurements in the top and bottom quartiles for gestational age and day the specimen was collected. Results The concentrations of 2 neurotrophic proteins, NT4 and BDNF, were low among children delivered for medical (maternal or fetal) indications, and among those who were growth restricted. Children who had top quartile concentrations of NT4, BDNF, and bFGF tended to have elevated concentrations of inflammation-related proteins that day. This pattern persisted for much of the first postnatal month Conclusions Delivery for medical indications and fetal growth restriction are associated with a relative paucity of NT4 and BDNF concentrations during the first 24 hours after very preterm birth. Elevated blood concentrations of NT4, BDNF, and bFGF tended to co-occur with indicators of systemic inflammation on the same day.

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Section: Discussionmentioning

confidence: 99%

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

et al. 2017

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“…In humans, BDNF levels are altered in attentional, neurodevelopmental, and stress-related mood and anxiety disorders [17–21]. At birth, higher maternal blood but lower cord blood and placental BDNF levels are associated with prematurity and lower gestational age [22–26], with cord blood levels also predicting birth complications [27, 28]. …”

Section: Introductionmentioning

confidence: 99%

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

et al. 2017

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BackgroundThe BDNF gene codes for brain-derived neurotrophic factor, a growth factor involved in neural development, cell differentiation, and synaptic plasticity. Present in both the brain and periphery, BDNF plays critical roles throughout the body and is essential for placental and fetal development. Rodent studies show that early life stress, including prenatal stress, broadly alters BDNF methylation, with presumed changes in gene expression. No studies have assessed prenatal exposure to maternal traumatic stress and BDNF methylation in humans. This study examined associations of prenatal exposure to maternal stress and BDNF methylation at CpG sites across the BDNF gene.ResultsAmong 24 mothers and newborns in the eastern Democratic Republic of Congo, a region with extreme conflict and violence to women, maternal experiences of war trauma and chronic stress were associated with BDNF methylation in umbilical cord blood, placental tissue, and maternal venous blood. Associations of maternal stress and BDNF methylation showed high tissue specificity. The majority of significant associations were observed in putative transcription factor binding regions.ConclusionsThis is the first study in humans to examine BDNF methylation in relation to prenatal exposure to maternal stress in three tissues simultaneously and the first in any mammalian species to report associations of prenatal stress and BDNF methylation in placental tissue. The findings add to the growing body of evidence highlighting the importance of considering epigenetic effects when examining the impacts of trauma and stress, not only for adults but also for offspring exposed via effects transmitted before birth.Electronic supplementary materialThe online version of this article (doi:10.1186/s13148-017-0367-x) contains supplementary material, which is available to authorized users.

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“…[26][27][28] We have recently reported differential levels of oxidative stress markers and neurotrophins in the different regions of the placenta. 29,30 In vitro studies suggest that neurotrophins stimulate the MMP expression through regulation of various signaling pathways. 31,32 In addition, cytokine protein concentrations are known to vary across different regions of the placenta 33 which may affect the MMP expression since inflammatory cytokines upregulate the production of MMPs.…”

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confidence: 99%

Matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases ‐9 (MMP‐9) are differentially expressed in different regions of normal and preeclampsia placentae

Sahay

Jadhav

Sundrani

et al. 2018

J of Cellular Biochemistry

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Matrix metalloproteinases (MMPs) are involved in the extracellular matrix (ECM) remodeling during human placentation and parturition and have been shown to be associated with oxidative stress. Placental regional changes in oxygen availability and oxidative stress indices may influence regional differences in expression of MMPs. This study examines the protein and mRNA levels of MMP-2 and MMP-9 in different regions of the placenta in normotensive control (NC) women and women with preeclampsia (PE). Fifty-two NC women and 43 women with PE (18 delivered at term [T-PE] and 25 delivered preterm [PT-PE]) were recruited. Placental samples were taken from four regions: central basal (CM), central chorionic (CF), peripheral basal (PM), and peripheral chorionic (PF). MMP protein and mRNA levels were measured by ELISA and quantitative real time PCR, respectively. MMP-2 protein levels were higher in all the placental regions (P < 0.05) from PT-PE group as compared to the respective regions from the NC and T-PE groups. MMP-9 mRNA levels were higher in CM region as compared to CF and PM regions (P < 0.05) in the NC group and compared to CF and PF regions (P < 0.05) in the T-PE group. The MMP-9 mRNA levels were lower in the CF region in the PT-PE and T-PE groups (P < 0.05) as compared to the NC group. Elevated levels of MMP-2 protein levels were observed in all regions of PT-PE placenta possibly influencing the degradation of placental ECM. Lower mRNA expression of MMP-9 both in PT-PE and T-PE may contribute to a disturbed placental vascularization.

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Neurotrophin levels in different regions of the placenta and their association with birth outcome and blood pressure

Cited by 28 publications

References 44 publications

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

Antecedents and correlates of blood concentrations of neurotrophic growth factors in very preterm newborns

BNDF methylation in mothers and newborns is associated with maternal exposure to war trauma

Matrix metalloproteinases‐2 (MMP‐2) and matrix metalloproteinases ‐9 (MMP‐9) are differentially expressed in different regions of normal and preeclampsia placentae

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