2009
DOI: 10.1159/000243766
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Neurotrophin Receptors TrkA and TrkB in Retinoblastoma Are Differentially Expressed Depending on Cellular Differentiation

Abstract: Retinoblastoma is the most common primary intraocular malignancy in children. With the progression of retinoblastoma, retinoblastoma cells lose their ability to differentiate. Regardless of many attempts to identify prognostic factors in retinoblastoma, further investigation for prognostic factors of retinoblastoma progression is still required because of the lack of sensitivity and specificity of these prognostic factors in predicting disease progression. We demonstrated that the differential expression of th… Show more

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Cited by 5 publications
(11 citation statements)
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References 27 publications
(44 reference statements)
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“…As demonstrated in figure 1B, TrkA as well as VEGFR-2 were expressed in high level in both retinoblastoma cell lines. As depicted in our recent report [20], neurotrophin receptors including TrkA and TrkB are differentially expressed in retinoblastoma cells depending on cellular differentiation status. In particular, TrkA expression is related to differentiation of retinoblastoma cells.…”
Section: Resultsmentioning
confidence: 63%
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“…As demonstrated in figure 1B, TrkA as well as VEGFR-2 were expressed in high level in both retinoblastoma cell lines. As depicted in our recent report [20], neurotrophin receptors including TrkA and TrkB are differentially expressed in retinoblastoma cells depending on cellular differentiation status. In particular, TrkA expression is related to differentiation of retinoblastoma cells.…”
Section: Resultsmentioning
confidence: 63%
“…Considering our recent report that TrkA is involved in differentiation of retinoblastoma cells [20], This VEGF-induced activation of TrkA strongly encourage to investigate the effect of VEGF blockade on differentiation of retinoblastoma cells. Expectedly, VEGF neutralization using bevacizumab could lead to inhibition of differentiation of retinoblastoma cells without any affection to cellular viability.…”
Section: Discussionmentioning
confidence: 95%
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“…In the progression of retinoblastoma, retinoblastoma tumors lose their characteristics of differentiated retinal cells [8, 9]. Retinoblastoma tumors from patients who underwent enucleation at older age demonstrate fewer Flexner-Wintersteiner rosettes which represent differentiated retinoblastoma tumors [6].…”
Section: Discussionmentioning
confidence: 99%
“…Retinoblastoma cells which constitute Flexner-Wintersteiner rosettes retain features of primordial photoreceptor cells [47]. However, as in other cancers, with the progression of retinoblastoma, retinoblastoma cells lose their ability to differentiate [8, 9] and there was a significant inverse relationship between age at enucleation and the degree of tumor differentiation, demonstrated by the presence of rosettes [6]. …”
Section: Introductionmentioning
confidence: 99%