Neurotrophin Regulation and Signaling in Airway Smooth Muscle

Roos, B.; Teske, J.J.; Bhallamudi, Sangeeta; Pabelick, Christina M.; Sathish, Venkatachalem; Prakash, Y. S.

doi:10.1007/978-3-030-68748-9_7

Cited by 2 publications

(2 citation statements)

References 132 publications

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“…The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats (CNS), in addition to secreting various cytokines, can also secrete neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF) (5). Classical neurotrophins are now known to be expressed and functional in nonneuronal systems including lung (6). Experimental airway allergy can activate microglia and increase brain-derived neurotrophic factor (BDNF) concentration of the airway (7), but it is unclear whether GDNF increases in the airway.…”

Section: Original Articlementioning

confidence: 99%

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats

Wang¹,

Wang²,

Chen³

et al. 2023

Ann Transl Med

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Background Asthma is a common chronic inflammatory disease of the airway, but the mechanism is still not fully understood. This study aimed to investigate the effect of glial cell line-derived neurotrophic factor (GDNF) on asthma attacks. Methods An asthmatic rat model was established. GDNF expression in the airway and brain was observed by immunohistochemistry (IHC), and the concentration of GDNF in bronchoalveolar lavage fluid (BALF) was detected by enzyme-linked immunosorbent assay (ELISA). After injection of GDNF and its antibody into the lateral ventricle of asthmatic rats, the pulmonary function was recorded, and the levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in BALF were tested. Results GDNF expressions were increased significantly in the lung tissues of asthmatic rats. In the central nervous system (CNS), GDNF-positive immunoreactive substances were observed in multiple brain regions, including the medial amygdala (MeA), paraventricular nucleus (PVN), cortex, and nucleus of solitary tract (NTS). After injection of GDNF into the lateral ventricles of asthmatic rats, the symptoms of asthma and airway inflammation were significantly aggravated, which could be improved by injection of GDNF antibody into the lateral ventricles. Conclusions GDNF expression is increased in the lung and brain in asthmatic rats. During an asthma attack, the increased GDNF expressions in the rat brain remarkably aggravate the asthmatic symptoms.

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Section: Original Articlementioning

confidence: 99%

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats

Wang¹,

Wang²,

Chen³

et al. 2023

Ann Transl Med

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“…Nerve growth factor is a high molecular weight polypeptide and one of the earliest neurotrophic factors (neurotrophin) ( 167 ). It can not only exert biological activity on the central and peripheral nervous system by means of target cell secretion, autocrine or paracrine, but also regulate a variety of allergic inflammatory effector cells (eosinophils, Th2 and mast cells) to exert biological activity on the immune system ( 168 ), thus playing a role in asthma inflammation such as airway remodeling and bronchial hyperresponsiveness ( 169 ).…”

Section: Neuroendocrine-related Signaling Protein Acts As Messenger I...mentioning

confidence: 99%

Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma

et al. 2022

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Asthma is a complex syndrome with polygenetic tendency and multiple phenotypes, which has variable expiratory airflow limitation and respiratory symptoms that vary over time and in intensity. In recent years, continuous industrial development has seriously impacted the climate and air quality at a global scale. It has been verified that climate change can induce asthma in predisposed individuals and that atmospheric pollution can exacerbate asthma severity. At present, a subset of patients is resistant to the drug therapy for asthma. Hence, it is urgent to find new ideas for asthma prevention and treatment. In this review, we discuss the prescription, composition, formulation, and mechanism of traditional Chinese medicine monomer, traditional Chinese medicine monomer complex, single herbs, and traditional Chinese patent medicine in the treatment of asthma. We also discuss the effects of Chinese herbal medicine on asthma from the perspective of cellular endocrinology in the past decade, emphasizing on the roles as intracellular and extracellular messengers of three substances—hormones, substances secreted by pulmonary neuroendocrine cells, and neuroendocrine-related signaling protein—which provide the theoretical basis for clinical application and new drug development.

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Neurotrophin Regulation and Signaling in Airway Smooth Muscle

Cited by 2 publications

References 132 publications

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats

Potential cellular endocrinology mechanisms underlying the effects of Chinese herbal medicine therapy on asthma

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