Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

Gibon, Julien; Barker, Philip A.

doi:10.1177/1073858417697037

Cited by 94 publications

(71 citation statements)

References 148 publications

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“…Another effect of SSRIs is an increase in the production of neurotrophins, in particular, BDNF, which promotes neurogenesis and synaptogenesis in some of the key regions for emotional processing, in particular hippocampus (Gibon and Barker 2017). BDNF was shown to have an antidepressant effect in animal models of depression, for example, it increased time spent in the open arms of an elevated plus maze; mobility in the forced swim test; and sucrose consumption, and decreased latency in the novelty-induced hypophagia test (Phillips 2017).…”

Section: Can Putative Biological and Psychological Effects Of Ads On mentioning

confidence: 99%

Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment

Godlewska

Harmer

2020

Psychopharmacology

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Depression is a leading cause of disability worldwide and improving its treatment is a core research priority for future programmes. A change in the view of psychological and biological processes, from seeing them as separate to complementing one another, has introduced new perspectives on pathological mechanisms of depression and treatment mode of action. This review presents a theoretical model that incorporated this novel approach, the cognitive neuropsychological hypothesis of antidepressant action. This model proposes that antidepressant treatments decrease the negative bias in the processing of emotionally salient information early in the course of antidepressant treatment, which leads to the clinically significant mood improvement later in treatment. The paper discusses the role of negative affective biases in the development of depression and response to antidepressant treatments. It also discusses whether the model can be applied to other antidepressant interventions and its potential translational value, including treatment choice, prediction of response and drug development.

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Section: Can Putative Biological and Psychological Effects Of Ads On mentioning

confidence: 99%

Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment

Godlewska

Harmer

2020

Psychopharmacology

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“…We speculate that the positive association between neuroplasticity and worse mental health reflects a dysfunctional neuroplastic process. Moreover, there is a complex, context-dependent interaction between mature neurotrophins or their pre-processed proneurotrophin moieties and their cognate receptors, which can promote neuronal maintenance/survival or cell death, respectively [36,46]. Whereas our ELISA assays could not differentiate between pro-and mature BDNF or NGF levels in plasma, further research will be…”

Section: Plos Onementioning

confidence: 88%

Dysfunctional neuroplasticity in newly arrived Middle Eastern refugees in the U.S.: Association with environmental exposures and mental health symptoms

et al. 2020

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Background Psychological war trauma among displaced refugees is an established risk factor for mental health disorders, especially post-traumatic stress disorder (PTSD). Persons with traumainduced disorders have heightened neuroplastic restructuring of limbic brain circuits (e.g., amygdala and hippocampus), which are critical factors in the pathophysiology of PTSD. Civilians in war are exposed to both psychological trauma and environmental hazards, such as metals. Little is known about the possible mental health impact from such environmental exposures, alone or in combination with trauma. It is of special interest to determine whether war exposures contribute to dysfunctional neuroplasticity; that is, an adverse outcome from sustained stress contributing to mental health disorders. The current study examined Middle Eastern refugees in the United States to determine the relationships among pre-displacement trauma and environmental exposures, brain derived neurotrophic growth factor (BDNF) and nerve growth factor (NGF)-two neurotrophins reported to mediate neuroplasticity responses to stress-related exposures-and mental health. Methods Middle Eastern refugees (n = 64; 33 men, 31 women) from Syria (n = 40) or Iraq (n = 24) were assessed 1 month after arrival to Michigan, US. Participants were interviewed in Arabic using a semi-structured survey to assess pre-displacement trauma and environmental exposure, PTSD, depression, anxiety, and self-rated mental health. Whole blood was collected, and concentrations of six heavy metals as well as BDNF and NGF levels were determined. Because these two neurotrophins have similar functions in neuroplasticity, we

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“…À l'inverse, l'activation de p75NTR recrute le nuclear factor-kB, les Jun kinases, et d'autres voies de signalisation pro-inflammatoires (Skaper, 2018). Les neurotrophines et la signalisation TrK sont des éléments essentiels dans les phénomènes d'activité et de plasticité synaptique impliqués dans la différenciation et la prolifération cellulaire, et notamment la prolifération des épines dendritiques mise en jeu dans la dépression et son traitement (Gibon & Barker, 2017). Nous parlerons également du glial cell line-derived neurotrophic factor (GDNF), qui n'est pas classé comme une neurotrophine à cause de son origine génétique distincte, mais qui est néanmoins un facteur neurotrophique très impliqué dans la survie et la plasticité neuronale, en particulier pour les neurones dopaminergiques (Lin et al, 1993).…”

Section: Les Systèmes Neurotrophiquesunclassified

Utilisation des psychédéliques en psychiatrie : lien avec les neurotrophines

Corne

Mongeau

2019

Biologie Aujourd’hui

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Reçu le 29 avril 2019Résumé --Les psychédéliques, souvent appelés hallucinogènes, sont une classe de psychotropes très singulière. Les effets subjectifs et comportementaux qu'ils induisent sont très impressionnants, et malgré leur toxicité potentielle, le risque d'addiction est relativement faible par rapport à la nicotine, l'alcool ou les opiacés. Depuis la découverte des effets antidépresseurs de la kétamine, il existe un regain d'intérêt pour cette classe de molécules. En effet, la psilocybine et l'acide lysergique diéthylamide (LSD) gagnent de la popularité en tant que traitement pour la dépression et l'addiction, la 3,4-méthylènedioxyméthamphétamine (MDMA) pour l'état de stress post-traumatique, et l'ibogaïne pour l'addiction. Malgré des profils pharmacologiques distincts, ces différentes drogues partagent une cinétique d'action similaire : leurs effets thérapeutiques se font ressentir dans les heures suivant l'administration et perdurent au-delà de leur élimination par l'organisme. Ceci suggère des mécanismes plastiques et neurogéniques impliquant entre autres des facteurs trophiques. Cette revue explorera la littérature concernant les effets de ces différents composés sur les neurotrophines, ainsi que les adaptations plastiques qui sont mises en place dans les heures et jours suivant l'administration, afin de comprendre leur potentiel thérapeutique étonnant. Abstract --Neurotrophic mechanisms of psychedelic therapy. Psychedelic drugs, often referred to as hallucinogens, are quite distinct from other classes of psychotropic drugs. Although the subjective and behavioral effects they induce are quite dramatic, they possess little addictive potential when compared to nicotine, alcohol or opiates. Since the discovery of ketamine antidepressant effects, there has been growing interest for these molecules. Serotonergic psychedelics such as psilocybin and lysergic acid diethylamide (LSD) are gaining attention as potential treatments for depression and addiction, similarly to 3,4-methylenedioxymethamphetamine (MDMA) for post-traumatic stress disorder (PTSD), and ibogaine for addiction. Although they possess distinct pharmacological profiles, their kinetics of action are quite similar: the therapeutic effects are felt within the hours following administration, and last well beyond drug elimination by the organism. This strongly suggests the induction of neurogenic and plastic mechanisms, including the involvement of trophic factors. This review will explore the literature dealing with the effects of psychedelics on neurotrophins, as well as the plastic adaptations that they induce, in an attempt to understand their surprising therapeutic potential. We will show that although ketamine and serotonergic psychedelics have affinity for very different receptors (NMDA, 5-HT2A), they ultimately initiate similar plastic adaptations in the prefrontal cortex through the involvement of the brain-derived neurotrophic factor (BDNF). We will see that although MDMA uses the same receptors as serotonergic psychedelics to alleviate P...

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Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

Cited by 94 publications

References 148 publications

Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment

Cognitive neuropsychological theory of antidepressant action: a modern-day approach to depression and its treatment

Dysfunctional neuroplasticity in newly arrived Middle Eastern refugees in the U.S.: Association with environmental exposures and mental health symptoms

Utilisation des psychédéliques en psychiatrie : lien avec les neurotrophines

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