Neurotrophins in allergic diseases: From neuronal growth factors to intercellular signaling molecules

Nockher, Wolfgang Andreas; Renz, Harald

doi:10.1016/j.jaci.2005.11.049

Cited by 114 publications

(75 citation statements)

References 66 publications

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“…NGF and other members of the neurotrophin family were initially identified as neuronal growth and survival factors but are currently recognised to have biological activities in tissues outside the nervous system [31]. Various visceral epithelia are known to produce neurotrophins which were initially speculated to regulate tissue innervation [32] and autocrine functions of neurotrophins are increasingly being described.…”

Section: Discussionmentioning

confidence: 99%

Nerve growth factor enhances Clara cell proliferation after lung injury

Sonar¹,

Schwinge²,

Kılıç³

et al. 2010

Eur Respir J

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The lung epithelia facilitate wound closure by secretion of various cytokines and growth factors. Nerve growth factor (NGF) has been well described in airway inflammation; however, its likely role in lung repair has not been examined thus far.To investigate the repair function of NGF, experiments were performed in vitro using cultured alveolar epithelial cells and in vivo using a naphthalene-induced model of Clara epithelial cell injury.Both in vitro and in vivo experiments revealed airway epithelial cell proliferation following injury to be dependent on NGF and the expression of its receptor, tropomyosin-receptor-kinase A. Additionally, NGF also augmented in vitro migration of alveolar type II cells. In vivo, transgenic mice over-expressing NGF in Clara cells (NGFtg) did not reveal any proliferation or alteration in Clara cell phenotype. However, following Clara cell specific injury, proliferation was increased in NGFtg and impaired upon inhibition of NGF. Furthermore, NGF also promoted the expression of collagen I and fibronectin in vitro and in vivo during repair, where significantly higher levels were measured in re-epithelialising NGFtg mice.Our study demonstrates that NGF promotes the proliferation of lung epithelium in vitro and the renewal of Clara cells following lung injury in vivo.

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Section: Discussionmentioning

confidence: 99%

Nerve growth factor enhances Clara cell proliferation after lung injury

Sonar¹,

Schwinge²,

Kılıç³

et al. 2010

Eur Respir J

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show abstract

“…It is notable that neurotrophins also have nonneural effects that relate to inflammation and immune functions, including promotion of eosinophil survival in the tissue, chemoattraction of mast cells, and promotion of their survival and upregulation of basophil releasability. 177,178 They certainly represent another example of the complex interplay between the nervous and immune systems, which has yet to be elucidated.…”

Section: Sensory Nerve Endingsmentioning

confidence: 99%

The role of the nervous system in rhinitis

Sarin¹,

Undem²,

Sanico³

et al. 2006

Journal of Allergy and Clinical Immunology

210

157

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“…Neurotrophins have also been proved to exert angiogenetic and microvascular remodeling activity during allergic airway inflammation. 8 Thus an innovative future perspective in research could be to investigate the angiogenetic effects of neurotrophins in AD. Furthermore, patients with AD have exaggerated vasodilator responses to emotional stress, with consequent pruritus and scratching.…”

Section: Neurovascular Interactions In Atopic Dermatitismentioning

confidence: 99%