Neurotropic activity of aldehyde and ketone thiosemicarbazones with a heterocyclic component

Di-2-pyridyl ketoneN4,N4-(butane-1,4-diyl)thiosemicarbazone

“…Thiosemicarbazones of -N-heterocyclic carbaldehydes act as tridentate ligands. The biological activity of the thiosemicarbazone depends on the parent aldehyde or ketone (Padhye & Kauffman, 1985;Liberta & West, 1992;Lukevics et al, 1995). Among thousands of screened compounds (Klayman et al, 1979), 2-acetylpyridine thiosemicarbazones were the ®rst compounds reported as potent antimalarial agents.…”

Terephthalaldehyde bis(thiosemicarbazone) bis(dimethylformamide) solvate

“…Recently, there has been considerable interest in the coordination chemistry of thiosemicarbazones because of their biological and carcinostatic activities (Liu et al, 1995;Lukevics et al, 1996) and their non-linear optical properties (Tian et al, 1997;Liu et al, 1999). It has been postulated that extensive electron delocalization in the thiosemicarbazone moiety helps the free thiosemicarbazone ligands and their metal complexes to exhibit SHG (second harmonic generation) ef®ciency (Tian et al, 1997;Liu et al, 1999).…”

An Update of the Use of Thiocarbohydrazides and Thiosemicarbazides in the Preparation of Heterocycles and Their Biological Importance

“…Such systems found to have potential applications in biological and material science. Thiosemicarbazone and thiocarbazone belong to a large group of thiourea derivatives, which have shown wide biological activities .…”