Neurovascular coupling dysfunction of visual network organization in Parkinson's disease

Li, Ting; Liu, Tiantian; Zhang, Jian; Ma, Yunxiao; Wang, Gongshu; Suo, Dingjie; Yang, Bowen; Wang, Xiu; Funahashi, Shintaro; Zhang, Kai; Fang, Boyan; Yan, Tianyi

doi:10.1016/j.nbd.2023.106323

Cited by 6 publications

(1 citation statement)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some researchers analyzed the neurovascular decoupling state of PD with cognitive impairment (103), and the results showed that the uncoupling region included the left striatum and the right frontal lobe, and participated in the regulation of PD cognitive impairment, which was consistent with the results of this study. In addition, another study showed that neurovascular decoupling in the visual cortex of PD patients was associated with visual functional impairment, and it was confirmed that changes in neurovascular coupling state were not related to changes in gray matter volume (GMV) after regression (104). GMV had always been an important confounding factor in neuroimaging, and the above studies suggested that neurovascular coupling may be a potential analysis indicator unaffected by GMV, with broader application prospects.…”

Section: Discussionmentioning

confidence: 87%

Abnormalities of cerebral blood flow and the regional brain function in Parkinson’s disease: a systematic review and multimodal neuroimaging meta-analysis

Xie,

Yang,

Sun

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

BackgroundParkinson’s disease (PD) is a neurodegenerative disease with high incidence rate. Resting state functional magnetic resonance imaging (rs-fMRI), as a widely used method for studying neurodegenerative diseases, has not yet been combined with two important indicators, amplitude low-frequency fluctuation (ALFF) and cerebral blood flow (CBF), for standardized analysis of PD.MethodsIn this study, we used seed-based d-mapping and permutation of subject images (SDM-PSI) software to investigate the changes in ALFF and CBF of PD patients. After obtaining the regions of PD with changes in ALFF or CBF, we conducted a multimodal analysis to identify brain regions where ALFF and CBF changed together or could not synchronize.ResultsThe final study included 31 eligible trials with 37 data sets. The main analysis results showed that the ALFF of the left striatum and left anterior thalamic projection decreased in PD patients, while the CBF of the right superior frontal gyrus decreased. However, the results of multimodal analysis suggested that there were no statistically significant brain regions. In addition, the decrease of ALFF in the left striatum and the decrease of CBF in the right superior frontal gyrus was correlated with the decrease in clinical cognitive scores.ConclusionPD patients had a series of spontaneous brain activity abnormalities, mainly involving brain regions related to the striatum-thalamic-cortex circuit, and related to the clinical manifestations of PD. Among them, the left striatum and right superior frontal gyrus are more closely related to cognition.Systematic review registrationhttps://www.crd.york.ac.uk/ PROSPERO (CRD42023390914).

show abstract

Section: Discussionmentioning

confidence: 87%