Neurovascular decoupling in type 2 diabetes mellitus without mild cognitive impairment: Potential biomarker for early cognitive impairment

Yu, Ying; Yan, Lin‐Feng; Sun, Qian; Hu, Bo; Zhang, Jin; Yang, Yang; Dai, Yujie; Cui, Wu-Xun; Xiu, Si-Jie; Hu, Yu-Chuan; Heng, Chun-Ni; Liu, Qingquan; Hou, Jingbo; Pan, Yu-Yun; Zhai, Lianghao; Han, Teng-Hui; Cui, Guangbin; Wang, Wen

doi:10.1016/j.neuroimage.2019.06.058

Cited by 44 publications

(42 citation statements)

References 85 publications

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“…Most of the T2DM subjects were younger than 50 years and had no obvious vascular complications, such as retinopathy and cerebrovascular diseases. This may explain why cognitive functions of the T2DM group are not significantly impaired (5). MoCA-B mainly assesses attention and concentration and has different sensitivity in different mental disorder diseases (35).…”

Section: Cognition Assessment Of Type 2 Diabetes Mellitus and Healthymentioning

confidence: 99%

“…Mild cognitive impairment (MCI), an important complication of T2DM, is intermediate transition state between age-appropriate cognition and dementia (4). Although the integral cognitive function kept "normal" up for a long time before MCI, there has been a gradually imperceptible decline in some aspects of cognitive function (5,6). Early detection of the brain functional changes of this stage could be clinically significant, because it might provide theoretical evidence for explaining cognitive changes related to T2DM and might greatly postpone the onset of MCI.…”

Section: Introductionmentioning

confidence: 99%

“…However, only a few studies kept a watchful eye on the early neuroimaging changes in T2DM subjects without MCI, and the underlying mechanisms have not been entirely elaborated. In a previous study, neurovascular decoupling pattern in T2DM without MCI was assessed using a variety of imaging methods (5). In another study, alterations in connectivity within the Papez circuit in T2DM patients without MCI were identified, and the relationships between these alterations and insulin resistance have been determined (11).…”

Section: Introductionmentioning

confidence: 99%

“…DC has been widely used to quantify node features of networks, and increased DC regions are defined as functional hubs (22). Previous researches using DC analysis showed altered brain functional hubs and connectivity in T2DM subjects (5,23,24). However, subjects enrolled in these studies had clinical cognitive impairment or lacked cognitive assessment.…”

Section: Introductionmentioning

confidence: 99%

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Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Liang

Tan

et al. 2020

Front. Neurol.

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Background: Type 2 diabetes mellitus (T2DM)-related cognitive decline is associated with neuroimaging changes. However, only a few studies have focused on early functional alteration in T2DM prior to mild cognitive impairment (MCI). This study aimed to investigate the early changes of global connectivity patterns in T2DM by using a resting-state functional magnetic resonance imaging (rs-fMRI) technique. Methods: Thirty-four T2DM subjects and 38 age-, sex-, and education-matched healthy controls (HCs) underwent rs-fMRI in a 3T MRI scanner. Degree centrality (DC) was used to identify the functional hubs of the whole brain in T2DM without MCI. Then the functional connectivity (FC) between hubs and the rest of the brain was assessed by using the hub-based approach. Results: Compared with HCs, T2DM subjects showed increased DC in the right cerebellum lobules III-V. Hub-based FC analysis found that the right cerebellum lobules III-V of T2DM subjects had increased FC with the right cerebellum crus II and lobule VI, the right temporal inferior/middle gyrus, and the right hippocampus. Conclusions: Increased DC in the right cerebellum regions III-V, as well as increased FC within cerebellar regions and ipsilateral cerebrocerebellar regions, may indicate an important pathophysiological mechanism for compensation in T2DM without MCI.

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Section: Cognition Assessment Of Type 2 Diabetes Mellitus and Healthymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Liang

Tan

et al. 2020

Front. Neurol.

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“…9,39 Yu et al reported that patients with T2DM displayed significant changes in the absolute cerebral blood flow-mean ALFF coupling of the cerebral blood flow-network, which was involved in the temporal lobe. 40 A neuroimaging study also revealed that patients with T2DM and mild cognitive impairment exhibited significant ALFF alterations in the temporal lobe. 30 Consistent with the prior findings, we observed significantly higher ALFF values in the left ITG of patients with DR, indicating stronger local spontaneous brain activity than that observed in HCs.…”

Section: Dovepressmentioning

confidence: 95%

<p>Altered Intrinsic Brain Activities in Patients with Diabetic Retinopathy Using Amplitude of Low-frequency Fluctuation: A Resting-state fMRI Study</p>

Qi¹,

Huang²,

Shen³

2020

DMSO

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Objective: The current study aimed to apply the amplitude of low-frequency fluctuation (ALFF) method for investigating the spontaneous brain activity alterations and their relationships with clinical features in patients with diabetic retinopathy (DR). Patients and Methods: In total, 35 patients with DR (18 males and 17 females) and 38 healthy control (HC) subjects (18 males and 20 females) were enrolled in this study. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning, respectively. The ALFF method was used to assess the spontaneous brain activity, while the mean ALFF signal values of patients with DR and HCs were classified by the receiver operating characteristic (ROC) curve. Correlation analysis was performed to calculate the relationship between the observed mean ALFF values of the altered regions in patients with DR and their clinical features. Results: Compared with the HCs, patients with DR had significantly lower ALFF values in the left and right middle occipital gyrus (MOG). In contrast, patients with DR showed higher ALFF values in the left cerebellum (CER), left inferior temporal gyrus (ITG) and left hippocampus (Hipp). However, no relationship was observed between the mean ALFF signal values of the altered regions and clinical manifestations in the patients with DR. Conclusion: We mainly found that patients with DR showed abnormal intrinsic brain activities in the left and right MOG, left CER, left ITG and left Hipp, which might provide useful information for explaining neural mechanisms in patients with DR.

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Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes

Zhang,

Huang,

Liu

et al. 2023

Ann Clin Transl Neurol

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ObjectiveWe aimed to reveal the role of structural and functional alterations of cingulate gyrus in early cognitive impairment in Type 2 diabetes mellitus (T2DM) patients.MethodsFifty‐six T2DM patients and 60 healthy controls (HCs) underwent a neuropsychological assessment and sagittal three‐dimensional T1‐weighted and resting‐state functional MRI. Differences in the cortical thickness of the cingulate cortex and the functional connectivity (FC) of the nine subregions of the cingulate gyrus and the whole brain were compared between T2DM patients and HCs. Correlation analysis was performed between cortex thickness and FC and the participants' clinical/cognitive variables.ResultsThe cortical thickness of the cingulate gyrus was not significantly different between T2DM patients and HCs. However, the T2DM patients showed significantly lower FC between the pregenual ACC (pACC) and the bilateral hippocampus, significantly higher FC between the pACC and bilateral lateral prefrontal cortex (LPFC) and left precentral gyrus, and significantly lower FC between the retrosplenial cortex (RSC) and right cerebellar Crus I. The FC between the pACC and the left hippocampus was negatively correlated with the FC between the pACC and LPFC (r = −0.306, p = 0.022).InterpretationThe pACC and the RSC show dysfunctional connectivity before the appearance of structural abnormalities in T2DM patients. Abnormal FC of the pACC with the bilateral hippocampus and LPFC may imply a neural compensatory mechanism for memory function. These findings provide valuable information and new directions for possible interventions for the T2DM‐related cognitive impairment.

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Neurovascular decoupling in type 2 diabetes mellitus without mild cognitive impairment: Potential biomarker for early cognitive impairment

Cited by 44 publications

References 85 publications

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

<p>Altered Intrinsic Brain Activities in Patients with Diabetic Retinopathy Using Amplitude of Low-frequency Fluctuation: A Resting-state fMRI Study</p>

Structural and functional connectivity alteration patterns of the cingulate gyrus in Type 2 diabetes

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